This demonstrates a potentially crucial role for
brain glial cells in mediating a fundamental physiological reflex.
A depiction of
the brain glial cell response towards site injury upon insertion of neural interface probe track (rectangular hole), which disrupts the maintenance of their important regulatory roles.
Not exact matches
It is also relevant here that one would have to take into account not only neurons but also,
glial cells since these contribute potentials to the electrical field of the
brain.
Small amounts of glycogen are found in the kidneys, and even smaller amounts in certain
glial cells in the
brain and white blood
cells.
The study is also the latest in recent years to implicate
glial cells in important
brain functions.
Until recently it has been difficult to study the role of
glial cells in controlling appetite or any other
brain function, because scientists haven't developed many techniques for silencing or stimulating these
cells, as they have for neurons.
«I was very curious at that point what
glial cells would be doing in the hypothalamus, since
glial cells have been shown in other
brain areas to have an influence on regulation of neuronal function,» she says.
MIT neuroscientists have discovered that
brain cells called
glial cells play a critical role in controlling appetite and feeding behavior.
There is more and more evidence to point to the importance of
glial cells in modulating neuronal function and in mediating
brain disorders,» says Guoping Feng, the James W. and Patricia Poitras Professor of Neuroscience.
Svendsen injected into their
brains a protein known to enhance neural development, called
glial cell line - derived neurotrophic factor (GDNF).
These
cells are similar to
brain astroglial
cells, and both types of
glial cells are activated after TBI.
The virus appears to invade the
brain by infecting a type of
glial cell called olfactory ensheathing
cells (OECs), which nourish smell - sensing neurons and guide them from the olfactory bulb to their targets in the nervous system.
The mice benefited from human stem
cells called
glial progenitors, immature
cells poised to become astrocytes and other glia
cells, the supposed support
cells of the
brain.
Two kinds of mouse
glial brain cells, microglia and astrocytes, making different versions of the APOE protein were grown with
brain nerve
cells, or neurons, that make disease - causing forms of tau.
Astrocytes — named for their starlike rays, which reach out in all directions — are the most abundant of all
glial cells and therefore the most abundant of all the
cells in the
brain.
They also applied it to human
brain tissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons,
glial cells, and other
cell types in the
brain (including rare types), and b) differentiate between closely related
cell subtypes.
According to tradition in neuroscience,
brain cells fall into two broad groups — neurons and
glial cells.
Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of
brain cancer called glioblastoma multiforme, a tumor of the
glial cells in the
brain.
Neural stem
cells called outer radial
glial (oRG)
cells help fuel the expansion of the unusually big human
brain.
Neurons release neurotransmitters that are taken up by specific receptors, but many
glial cells receive and emit neurotransmitters that float through the
brain as free agents.
Meet the forgotten 90 percent of your
brain:
glial cells, which outnumber your neurons ten to one.
Some
glial cells congregate near lesions, for instance, and in areas of the
brain where learning is going on.
This fluorescence light micrograph shows two important support
cells (
glial cells) of the human
brain.
Professor Ben Barres really uncovered the importance of these
glial cells on
brain injuries and diseases.
«Uncovering the power of
glial cells:
Brain implants can rely on more than neurons to function.»
Between the
brain's neurons and
glial cells is a critical but understudied structure that's been called neuroscience's final frontier: the extracellular space.
Kozai's lab is currently working with Franca Cambi, professor of neurology at Pitt, on a project to understand the role of another type of
glial cell on
brain injury and neuronal activity.
«By combining in vivo multiphoton microscopy and in vivo electrophysiology, our lab is better able to visualize how
cells move and change over time in the living
brain and explain how changes in these
glial cells alter the visually evoked neural network activity,» says Kozai.
The study, «
Glial responses to implanted electrodes in the brain,» suggests that these glial cells are more functional than previously tho
Glial responses to implanted electrodes in the
brain,» suggests that these
glial cells are more functional than previously tho
glial cells are more functional than previously thought.
«The most obvious function of
glial cells has been related to their role in forming scar tissue to prevent the spread of injury and neuronal degeneration, but so much about their role in the
brain is unknown.»
«From providing growth factor support and ensuring proper oxygen and nutrient delivery to the
brain to trimming of obsolete synapses and recycling waste products, recent findings show that
glial cells do much more to ensure
brain activity is optimized,» Kozai says.
Star - shaped astrocytes are the most abundant subgroup of
glial cells, which support and insulate neurons in the
brain and spinal cord.
«Our finding runs counter to the belief that increasing the reactivity of astrocytes and other
glial cells in the
brain helps maintain tissue integrity following TBI.
Monje first became interested in neurons» role supporting tumors while working on childhood glioma, a cancer that strikes in the precursors to
glial cells in the developing
brain.
Forward - looking studies are examining other possible information couriers:
glial cells (poorly understood
brain cells that are 10 times as common as neurons), other kinds of signaling mechanisms between
cells (such as newly discovered gases and peptides), and the biochemical cascades that take place inside
cells.
The p38 MAPK is also present in
glial cells, which are critical to the
brain's health and comprise 90 percent of
brain cells.
This brings up the possibility that
brain cancer
cells that originate from
glial cells can be forced into a mature state and thus unable to divide.
While the
brain actually has more
glial cells than neurons,
glial cells were long thought to provide only structural support to the neurons, much like cement supports a house.
Astrocytes are the most common of a type of
brain cell called
glial cells.
Neuroscientists have long believed that scar tissue formed by
glial cells — the
cells that surround neurons in the central nervous system — impedes damaged nerve
cells from regrowing after a
brain or spinal cord injury.
Astrocytes, one type of
glial cells are the supporting
cells for survival and function of neurons in the
brain by secreting many kinds of neuroprotective molecules.
Chen and his team began by studying how reactive
glial cells respond to a specific protein, NeuroD1, which is known to be important in the formation of nerve
cells in the hippocampus area of adult
brains.
The scientists have used supporting
cells of the central nervous system,
glial cells, to regenerate healthy and functional neurons, shown in green in this image in the
brain of a mouse with Alzheimer's disease.
«There are more reactive
glial cells and fewer functional neurons in the injury site,» Chen said, «so we hypothesized that we might be able to convert
glial cells in the scar into functional neurons at the site of injury in the
brain.
The scientists have used supporting
cells of the central nervous system,
glial cells, to regenerate healthy, functional neurons, which are critical for transmitting signals in the
brain.
When the
brain is harmed by injury or disease, neurons often die or degenerate, but
glial cells become more branched and numerous.
A human - specific gene expressed only in
glial cells of the
brain apparently arose from conversion of the ancestral gene by a nonfunctional pseudogene in a common human chimp ancestor.
«More importantly, a retrovirus can infect only dividing
cells such as reactive
glial cells, but it does not affect neurons, which makes it ideal for therapeutic use with minimal side effect on normal
brain functions.»
In a second test, Chen and his team used a transgenic - mouse model for Alzheimer's disease, and demonstrated that reactive
glial cells in the mouse's diseased
brain also can be converted into functional neurons.
Swathed in green threads, this
glial cell may hold clues for
brain repair.