Sentences with phrase «brain in mouse models of the disease»

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Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.
The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.
A drug that acts like a growth - promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's disease in two mouse models of the disorder, according to a study appearing November 27 in the Journal of Neuroscience.
Once the microglia were mobilized in mouse models of Alzheimer's disease, the researchers observed a more than 60 percent reduction in amyloid beta in the brain.
An international team of researchers has shown that a new small - molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.
In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioIn a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioin a mouse model of the neurodegenerative condition.
In a mouse model of Alzheimer's disease, Salk Institute researchers show that raising levels of neuregulin - 1 (right) lowers a marker of disease pathology in a part of the brain that controls memory compared with controls (leftIn a mouse model of Alzheimer's disease, Salk Institute researchers show that raising levels of neuregulin - 1 (right) lowers a marker of disease pathology in a part of the brain that controls memory compared with controls (leftin a part of the brain that controls memory compared with controls (left).
In the new study, Lee's team tested this idea in a mouse model of Alzheimer's disease by raising the levels of one of two forms of neuregulin - 1 in the hippocampus, an area of the brain responsible for learning and memorIn the new study, Lee's team tested this idea in a mouse model of Alzheimer's disease by raising the levels of one of two forms of neuregulin - 1 in the hippocampus, an area of the brain responsible for learning and memorin a mouse model of Alzheimer's disease by raising the levels of one of two forms of neuregulin - 1 in the hippocampus, an area of the brain responsible for learning and memorin the hippocampus, an area of the brain responsible for learning and memory.
Although genetically modified mice have been used widely to model neurodegenerative diseases, they lack the typical neurodegeneration or overt neuronal loss seen in human brains, says corresponding author Xiao - Jiang Li, MD, PhD, distinguished professor of human genetics at Emory University School of Medicine.
Blocking this process with a small - molecule drug prevented the characteristic brain plaques and memory loss in a mouse model of the disease.
In a recent paper in the Journal of Alzheimer's Disease, UTMB's research team detailed their investigation on the relationship between inflammation, toxic tau and Alzheimer's onset by performing systematic analyses of brain and retina samples from people with Alzheimer's and a mouse model of Alzheimer'In a recent paper in the Journal of Alzheimer's Disease, UTMB's research team detailed their investigation on the relationship between inflammation, toxic tau and Alzheimer's onset by performing systematic analyses of brain and retina samples from people with Alzheimer's and a mouse model of Alzheimer'in the Journal of Alzheimer's Disease, UTMB's research team detailed their investigation on the relationship between inflammation, toxic tau and Alzheimer's onset by performing systematic analyses of brain and retina samples from people with Alzheimer's and a mouse model of Alzheimer's.
Using two complementary approaches to reduce the deposits of amyloid - beta in the brain rather than either approach alone improved spatial navigation and memory in a mouse model of Alzheimer's disease.
Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.
And this applies to other areas of the brain as well as the hippocampus, where we are beginning to ask questions about how these areas become dysfunctional in mouse models of Alzheimer's disease.
The paper «Nav1.1 - Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease» was published online by Neuron on March 15, 2018.
Finally, we generate new tools and mouse models to study the role of de novo protein synthesis in normal brain function and in pathophysiology associated with neurodevelopmental and neurodegenerative disease.
The massive number of cells within the OSVZ of humans «tells us we have to be careful when modeling human brain diseases in mice,» says Kriegstein.
«Some imaging studies using mouse models of Alzheimer's disease had revealed the presence in these mice's brains of tiny, mysterious black dots that could signal the presence of iron, an element that shows up dark under MRI and, in certain chemical forms, can be highly reactive and inflammation - inducing,» Rutt said.
By directly altering the gene coding for the prion protein (PrP), Whitehead Institute researchers have created mouse models of two neurodegenerative prion diseases, each of which manifests in different regions of the brain.
In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer'In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer'in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer'in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer's.
A memory - related brain region in a mouse model of Alzheimer's disease.
This analysis revealed the striking increase in collagen VI in the brains of mice that model Alzheimer's disease.
These plaques are extracellular aggregations of a small protein called beta - amyloid that are prominent in diseased patients» brains, as well as in mouse models of the disease.
The researchers looked at the dentate gyrus, a specific area of the brain that is critical to memory and particularly vulnerable in Alzheimer's disease, and compared the genes that were turned on and off in normal mice and a mouse model of Alzheimer's disease.
The results were obtained from mice and human stem cells in cultivated brain tissue, and from a series of rodent models for human neurodegenerative diseases and acute brain injuries.
What's next: PNNL researchers are extending the quantitative proteomic methods developed in this work to the higher resolution investigation of disease models in mouse brains.
In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of brains of two different mouse models of Parkinson's disease.
In the PDAPP transgenic mouse model of Alzheimer's disease, immunization with A beta causes a marked reduction in burden of the brain amyloiIn the PDAPP transgenic mouse model of Alzheimer's disease, immunization with A beta causes a marked reduction in burden of the brain amyloiin burden of the brain amyloid.
A new study shows that increasing the activity a critical piece of machinery called «mTORC1» in a mouse model of Huntington's disease leads to improved motor problems and brain abnormalities associated with the disease.
SAN FRANCISCO, CA — Researchers at the Gladstone Institutes have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid - beta plaques (a hallmark of Alzheimer's disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition.
Changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.
In a study published in Neuron, Palop and his collaborators uncovered the therapeutic benefits of genetically improving these interneurons and transplanting them into the brain of a mouse model of Alzheimer's diseasIn a study published in Neuron, Palop and his collaborators uncovered the therapeutic benefits of genetically improving these interneurons and transplanting them into the brain of a mouse model of Alzheimer's diseasin Neuron, Palop and his collaborators uncovered the therapeutic benefits of genetically improving these interneurons and transplanting them into the brain of a mouse model of Alzheimer's disease.
Huang and colleagues previously reported that, during sharp - wave ripples in the hippocampus, patterns of brain activity thought to occur during memory replay and consolidation, gamma waves were disrupted in a mouse model of Alzheimer's disease.
Drugs that block signaling through this CRF receptor reduce brain damage and deficits in learning and memory in a mouse model of Alzheimer's, suggesting a new potential treatment for this devastating disease.
Our recent study has demonstrated that peripheral amylin treatment reduces the amyloid pathology in the brain of Alzheimer's disease (AD) mouse models, and improves their learning and memory.
Abstract: Our recent study has demonstrated that peripheral amylin treatment reduces the amyloid pathology in the brain of Alzheimer's disease (AD) mouse models, and improves their learning and memory.
Jorge Palop and his collaborators discovered that transplanting a special type of neuron into the brain restores cognitive functions in mouse models of Alzheimer's disease.
In a mouse model of Alzheimer's disease, he discovered abnormal patterns of brain activity that change the ability to learn and create memories.
In a hopeful development, scientists from the Conti lab have pinpointed a key factor controlling damage to brain cells in a mouse model of Parkinson's diseasIn a hopeful development, scientists from the Conti lab have pinpointed a key factor controlling damage to brain cells in a mouse model of Parkinson's diseasin a mouse model of Parkinson's disease.
SAN FRANCISCO, CA — Researchers at the Gladstone Institutes have shown that reducing brain levels of the protein tau effectively blocks the development of disease in a mouse model of Dravet syndrome, a severe intractable form of childhood epilepsy.
Using a mouse model for this disease, which in humans involves the destruction of white matter in the brain, a research team led by Albee Messing, director of the UW — Madison Waisman Center, found that a protein behind the symptoms of the disease, called GFAP, is broken down more rapidly in the body than researchers previously found in cell culture studies.
At JAX's new Alzheimer's Disease Precision Models Center, Howell is genetically manipulating mice to understand how unhealthy lifestyle habits trigger immune responses in the brain, leading to a cascade of events that may ultimately impair thinking and memory, as in Alzheimer's dDisease Precision Models Center, Howell is genetically manipulating mice to understand how unhealthy lifestyle habits trigger immune responses in the brain, leading to a cascade of events that may ultimately impair thinking and memory, as in Alzheimer's diseasedisease.
In mouse models of Parkinson's disease, Sulforaphane increased dopamine levels in the brain to alleviate loss of motor coordination (R, R, R, RIn mouse models of Parkinson's disease, Sulforaphane increased dopamine levels in the brain to alleviate loss of motor coordination (R, R, R, Rin the brain to alleviate loss of motor coordination (R, R, R, R).
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