Sentences with phrase «brain leads to the cell death»

Not exact matches

The results could provide insights into the Zika virus» recent emergence as a global health emergency, and also point to inhibitors of the protein p53 as potential leads for drugs that could protect brain cells from cell death.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

«After circulatory arrest, spreading depolarization marks the loss of stored electrochemical energy in brain cells and the onset of toxic processes that eventually lead to death.

Brain injuries, whether caused by trauma or neurodegeneration, lead to cell death accompanied by considerable functional impairment.

These proteins are thought to be a hallmark of Alzheimer's disease, and their formation may trigger other changes that lead to the death of brain cells.

«Shutting off vital tumour growth processes can lead to the death of human brain tumour - initiating cells.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

«Lithium chloride is known to block many pathways that lead to brain cell death, while promoting others that lead to survival, like brain - derived neurotrophic factor, or BDNF,» says Saito, a research assistant professor at NYU Langone.

«Our studies show that broken - down components of the nuclear transport machinery lead to traffic jams within brain neurons of essential information and eventually brain cell death,» says Grima.

When this happens, molecular nutrients can no longer move to where they are needed and the oligomers produce toxic effects leading to the eventual death of the brain cells.

The Cambodian strain also led to the death of a few brain cells, but perhaps not enough to cause microcephaly.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

The faulty gene leads to cell death in neurons in the brain resulting in gradual physical, mental and emotional changes, and ultimately death.

If the compound identified in this study successfully reduces tissue death and improves recovery in further experiments, it could lead to new approaches for preserving brain cells after an ischemic stroke,» said Francesca Bosetti, Ph.D., Pharm.D., program director at the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

These results collectively suggest that neural stem cells need MSI1 to generate enough neurons for normal brain size, but the presence of MSI1 also increases the vulnerability of these cells to Zika infection, leading to the death of the population which ultimately results in microcephaly.

Animal studies have shown that lengthy or multiple experiences with anesthesia can lead to cell death and problems with the formation of connections among brain cells.

This damages nerve cells by blocking their ability to make the proteins needed for synaptic function and leads to the death of neurons in the brain and spinal cord.

CAMBRIDGE, Mass. — Scientists know that in patients with Parkinson's disease, certain proteins in the brain form clusters that somehow contribute to cell death and, eventually, lead to the onset of the disease's debilitating symptoms.

Schindler said she is specifically interested in research being done on the amyloid protein, which is believed to cause plaques in the brain which lead to the death of nerve cells that cause dementia.

But now, scientists at the Gladstone Institutes have discovered how the interplay between two proteins in the brain fuels the degradation and death of the class of brain cells, or neurons, that leads to Parkinson's.

Recent studies reported that gestational nicotine exposure modulates the cell - adhesion and cell - death / survival systems in the brains of adolescent rats and may lead to numerous behavioral and physiological deficits [41], [42].

A possible hypothesis for exactly how stress contributes is that it may cause a neurotoxic reaction in the brain (primarily in the hippocampus) that leads to cell damage and death in individuals who are already vulnerable (due to genes or early environmental insult).

The Zika virus is known to negatively impact the growth of fetal brains and a group of researchers publishing in the journal Cell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferatCell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferatCell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferatcell death and reduced proliferation.

Cytoadhesion of P. falciparum in the brain leads to a large number of deaths each year and is a consequence of exported parasite proteins, some of which modify the erythrocyte cytoskeleton while others such as PfEMP1 project onto the erythrocyte surface where they bind to endothelial cells.

Consuming MSG can lead to migraine headaches, brain cell death, and impaired brain development in young children (source).

Amyloid protein forms clumps in the brains of patients, creating sticky plaques that lead to brain cell death.

It also helped protect against oxidative damage that leads to brain cell death, and reduced injury to brain endothelial cells in mice with high - fat diets.

Alzheimer's Disease is a progressive form of dementia that kills brain cells, leading to continual loss of memory, intellectual capacity, and eventual death.

From there, it travels up to the brain, where it attacks the cells, which can lead to certain death for dogs.

Any time the seizures are too frequent they can cause a process call «kindling» in which further (non-epileptic) brain cells are affected adversely leading to the next set of seizures occurring even sooner or lasting longer.8 Eventually some dogs have very frequent clusters of seizures happening multiple time in one day, or go into a continuous seizure (status epilepticus) which is life threatening and can lead to permanent brain damage or death.

Diffuse axonal injury — damage to the brain cells that isn't always as outwardly visible as other types of brain injury but can lead to permanent brain damage and death.