Sentences with phrase «brain metastases»

"Brain metastases" refers to cancer cells that have spread from another part of the body to the brain. It means that the cancer has spread into the brain and formed new tumors there. Full definition
[32] In patients with brain metastases in the AZD3759 phase I clinical trial, 63 % (12 of 19 patients) achieved an intracranial response and 50 % (10 of 20 patients) had an extracranial response.
Many lung cancer trials have traditionally excluded patients with brain metastases at baseline, expecting that the presence of metastases would create negative results that could in turn create the appearance of drug failure.
Stereotactic radiosurgery is an effective and commonly used treatment for brain metastases, but intracranial tumor progression is frequent after SRS alone, primarily because of the development of new metastatic lesions.
Approximately 30 percent of patients with cancer develop brain metastases, and the incidence of these lesions is rising.
Subgroup analyses showed benefit with the combination in all groups, with the exception of those with brain metastases at baseline, though this included a total of only 12 patients.
Safety and activity of pembrolizumab in melanoma patients with untreated brain metastases.
They and additional co-authors at the MGH Cancer Center, the University of North Carolina, Vanderbilt University and Novartis, identified HER3 — part of the same signaling pathway that includes HER2 — as a possible contributor to anti-HER2 / PI3K resistance in breast cancer brain metastases.
The Value of Diffusion Tensor Imaging in Differentiating High - Grade Gliomas from Brain Metastases: A Systematic Review and Meta - Analysis
In their search for novel, tumor - specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed a mouse model that more closely mimics what is seen in patients.
Novel strategies that are effective in treating brain metastases in patients with lung cancer are needed.
Brain metastases often manifest years after the primary tumour.
Whole brain radiotherapy (WBRT) significantly improves tumor control in the brain after SRS, yet because of its association with cognitive decline, its role in the treatment of patients with brain metastases remains controversial.
Researchers also examined the rates of overall survival (OS), development of distant brain metastases (DBM), time to WBRT, and complications following SRS.
«Our results are the first to provide insight into ways of targeting brain metastases with stem - cell - directed molecules that specifically induce the death of tumor cells and then eliminating the therapeutic stem cells.»
In their search for novel, tumor - specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed different BRAF wild type and mutant mouse models that more closely mimic what is seen in patients.
In this video we discuss the use of concurrent immunotherapy and stereotactic radiosurgery for treatment of melanoma brain metastases.
While target therapies directed toward genetic mutations that drive a tumor's growth have significantly improved the outlook for many patients, they have not been as successful in controlling brain metastases in several types of cancer.
«Brain metastases represent an unmet need in current cancer care.
Before this study was carried out, the extent to which the genetic profiles of brain metastases differ from that of the primary was unknown.
It is not enough to rely on the characteristics of the primary tumour because brain metastases have other specific gene alterations and in many patients this gives us better treatment alternatives.»
«New genes discovered regulating brain metastases in lung cancer patients.»
«We set out to find which genes can regulate the cells that initiate brain metastases, which we've termed brain metastasis initiating cells or BMICs.
«In the absence of a difference in overall survival, these findings suggest that for patients with 1 to 3 brain metastases amenable to radiosurgery, SRS alone may be a preferred strategy,» the authors write.
The Nakano lab is also working on brain metastases, tumors that spread into the brain from other parts of the body.
Brain metastases occur in a large number of patients with common cancers and are more prevalent than many primary tumors, including primary brain tumors, lymphoma and colon cancer.
The TGen team performed deep genomic profiling, integrating gene copy number, gene expression and DNA methylation datasets on a collection of 35 breast - brain metastases samples.
«HER3 has been associated with treatment resistance in several types of cancer, and our findings indicate that the overexpression of HER3 within the microenvironment of brain metastases reprograms the signaling pathways shut down by HER2 suppression,» says co-first author Ferraro.
Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.
In this case report from CNS Oncology the authors present a rare case of a patient with multiple recurrent brain metastases of pancreatic origin.
** The team used data from eTumour, a previous European research programme, on the chemical contents of 378 patient samples from five different types of brain tumours: glioblastomas, astrocytomas, meningiomas, oligodendrogliomas, and tumours that had spread to the brain, called brain metastases.
Another project has surveyed the group to discover the percentage of ROS1 patients who have experienced brain metastases.
Cumulative Intracranial Tumor Volume and Number of Brain Metastases as Predictors of Developing New Lesions After Stereotactic Radiosurgery for Brain Metastasis.
We aim to understand how brain metastases adapt to their environment and how we can target them better.
Randomized Phase II Study: Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis after Radiosurgery for Brain Metastases
«If you look at a set of lung cancer patients, like we did in the paper, who develop brain metastases, they all have those two genes in their primary lung cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School of Medicine, scientist with the Stem Cell and Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hospital.
[38] The median time to CNS progression was 7 months in patients with previously untreated brain metastases.
The need for new approaches to treating brain metastases is urgent, she will say.
Even where treatment is successfully controlling cancer elsewhere in the body, brain metastases often grow rapidly.»
Brain metastases remained controlled for a median 15.6 months.
Undergoing immunotherapy within a month of stereotactic radiosurgery resulted in an improved response to treatment for patients with melanoma brain metastases.
Dr. Anders, a native of Burlington, N.C., an assistant professor in the University of North Carolina at Chapel Hill School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center, was chosen for her work on the identification of the prognosis and treatment of breast cancer brain metastases.
Research from McMaster University has identified new regulators of brain metastases in patients with lung cancer.
For patients with non-small cell lung cancer with brain metastases, treatment with whole brain radiotherapy may not offer much benefit.
The subsequent development of brain metastases was studied by researchers.
«Viable treatment options for brain metastases are still an unmet need,» said Hong Zhao, M.D., Ph.D., assistant professor of systems medicine and bioengineering at Houston Methodist Research Institute and co-corresponding author.
Only a minority of fibrolamellar patients will develop brain metastases, Simon expects.
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