Sentences with phrase «brain pathology in»

HEAD, E. Combining an antioxidant fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging.

Kern JK, Geier DA, Audhya T, King PG, Sykes LK, Geier MR. Evidence of parallels between mercury intoxication and the brain pathology in autism.

The scientists previously revealed this amount of caffeine / coffee consumption was required to counteract the memory impairment and brain pathology in mice with Alzheimer's.

While those studies uncovered widespread functional and anatomical brain abnormalities in ASD, the results were not highly consistent, possibly reflecting the complex brain pathology in autism spectrum disorders.

However, a new study published Aug. 1 in Neurobiology of Aging provides the most extensive evidence of Alzheimer's disease brain pathology in a primate species to date.

«As we develop drugs that work by targeting the primary brain pathology in schizophrenia, it is likely that the differences between patients are going to play a bigger role in determining optimal treatment,» commented Dr. John Krystal, Editor of Biological Psychiatry.

He published his innovative textbook, Lehrbuch der Psychiatrie, in 1883, and this study emphasized the significance of brain pathology in psychiatric disorders as well as his considerable observations in support of this theory.

Not exact matches

So Yang Shi and her PhD advisor, neurologist David Holtzman at Washington University were in for a surprise when they peeked at a set of brain slices from mice engineered to produce tau pathology.

The idea for Smith's study was inspired by the work of co-author Alena Savonenko, M.D., Ph.D., associate professor of pathology, and her colleagues who showed that loss of serotonin neurons was associated with more protein clumps, or amyloid, in mouse brain.

Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.

«By learning how tau spreads, we may be able to stop it from jumping from neuron to neuron,» said Karen Duff, PhD, professor in the department of pathology and cell biology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) and professor of psychiatry (at New York State Psychiatric Institute.)

If the same dynamic plays out in human brains, hyperconnections in the developing cortex could result in the neural pathologies observed in human autism, Kanold said.

Dirk Keene, a neuropathologist at the University of Washington in Seattle who is working with McKee on another project to quantify the pathological changes in CTE, notes that the fact that men with damaged brains developed symptoms does not prove that the brain pathology caused the symptoms.

For example, brain anatomy could be more closely monitored in those people where there is suspicion of an increased risk of developing a mental disorder (the children of parents with mental health problems, for example), so that the probability of developing a pathology that interferes with their normal development can be estimated.

Accumulation of insoluble U1 protein was seen in samples from patients with mild cognitive impairment (MCI), a precursor stage to Alzheimer's, but the U1 pathology was not seen in any other brain diseases that were examined.

«This study, carried out using laboratory rats modeling stroke, demonstrated that ischemic stroke — in both its subacute and chronic stages — damages the BSCB in a variety of ways, creating a toxic environment in the spinal cord that can lead to further disability and exacerbate disease pathology,» said study lead author Dr. Svitlana Garbuzova - Davis, associate professor in USF's Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair.

They will also be conducting positron emission tomography, or PET, scans to look for amyloid and tau pathology in their brains as they age.

The UK researchers set out to investigate the mechanism by which the treatment may act in the brain to lower amyloid deposition (amyloid deposits being a key pathology in Alzheimer's).

The data suggests that modulating the immune response in the brain may help ameliorate the Alzheimer's pathology.

Hence, the researchers considered it worthwhile to investigate how alterations in BDNF signalling affect memory functions and brain pathology.

Those tests don't give us the details we need to understand the nature of the pathology at the cellular level, so we modeled the disease to perform a systematic analysis of the optic nerve, from its origin in the eyes to termination in the brain.»

«Integrating these molecular imaging tools offers the opportunity to investigate the possible independent and synergistic contribution of these protein pathologies in neurodegeneration in the living brain and, therefore, greatly advance our understanding of the mechanisms of Alzheimer's disease,» said Drzezga.

Our knowledge of immune - related pathologies in the brain and the ability to identify biomarkers for disease and inflammation are key for forming meaningful mechanistic conclusions.

The control group without MAb administration showed PD pathology in multiple brain areas over time, while the mice treated with Syn303 showed significantly reduced pathology in the same areas.

Groups did not differ in brain pathology scores.

New findings published in Biological Psychiatry brings us closer to understanding the pathology of autism, and the point at which it begins to take shape in the human brain.

In a mouse model of Alzheimer's disease, Salk Institute researchers show that raising levels of neuregulin - 1 (right) lowers a marker of disease pathology in a part of the brain that controls memory compared with controls (leftIn a mouse model of Alzheimer's disease, Salk Institute researchers show that raising levels of neuregulin - 1 (right) lowers a marker of disease pathology in a part of the brain that controls memory compared with controls (leftin a part of the brain that controls memory compared with controls (left).

By examining brain regions most affected by Alzheimer's disease pathology in humans, the group demonstrated that amyloid beta plaques and blood vessels were present in all 20 aged chimpanzee brains.

While approximately 80 percent of Alzheimer's disease patients also have cerebral amyloid angiopathy, or amyloid beta deposits in the brain's blood vessels that increase the risk for stroke and dementia, the predominant amyloid beta pathology is plaques.

«The presence of amyloid and tau pathology in aged chimpanzees indicates these Alzheimer's disease lesions are not specific to the human brain as generally believed,» Hof continued.

The discovery of brain pathology through autopsy in former National Football League (NFL) players called chronic traumatic encephalopathy (CTE) has raised substantial concern among players, medical professionals, and the general public about the impact of repetitive head trauma.

«Not only are there applications for healthy people to better realize their potential, but EEG - neurofeedback work has been extended to pathology, as in the case of children with attentional disabilities and [transcranial magnetic stimulation] for depression,» notes psychologist John Gruzelier of Goldsmiths College in London, who has been working on training musicians to control their own brain waves, thereby improving performance.

The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington's disease.

Last year, the Sports Legacy Institute, a nonprofit organization that promotes research on sports - related head injuries, announced the formation of a new research center in partnership with the Boston University School of Medicine to study neuropsychiatric symptoms in athletes and to examine donated brains for signs of pathology.

The brain regions with improved efficiency corresponded to those involved in the pathology of Alzheimer's disease, including the precuneus region, the temporal lobe, and the parahippocampal gyrus.

The paper by Collinge and his colleagues has sparked a worldwide hunt for similar amyloid pathology in autopsied brains, and a small study published this January revealed a handful of related cases.

Although the number of cases is still very small, and most have yet to be published in peer - reviewed journals, the researchers insist their preliminary findings are cause for concern because this type of brain pathology is virtually unheard of in people this young.

«The 32 percent of CTE we found in our brain bank is surprisingly high for the frequency of neurodegenerative pathology within the general population,» says the study's lead author, Kevin Bieniek, a predoctoral student in Mayo Graduate School's Neurobiology of Disease program.

In comparison, none of the 198 brains of individuals without documentation of participation in contact sports, including 66 women, had CTE pathologIn comparison, none of the 198 brains of individuals without documentation of participation in contact sports, including 66 women, had CTE pathologin contact sports, including 66 women, had CTE pathology.

The scientists had expected inflammation markers in the CSF to be more robust predictors of AD - related pathology and neuronal damage than those in the blood due to the «blood brain barrier.»

For Alzheimer's disease, the aim is for the investigational drug to target major pathologies of the disease and selectively activate a key receptor in the brain.

There is a finely graded inverse association between age and cognitive performance, 3 4 5 but the age at which cognitive decline becomes evident at the population level remains the subject of debate.5 6 7 A recent review of the literature concluded that there was little evidence of cognitive decline before the age of 60.8 This point of view, however, is not universally accepted.5 6 Clinicopathological studies show good correlation between neuropathology and the severity of cognitive decline, 9 10 11 and neurofibrillary tangles and amyloid plaques, the hallmarks of pathology, are known to be present in the brains of young adults.12 13 Emerging consensus on the long gestation period of dementia14 15 also suggests that adults aged under 60 are likely to experience age related cognitive decline.

Investigating BIN1 function in the brain and assessing the involvement of BIN1 in the disease pathology using appropriate in vivo models is a vital and key step.

Physiology and pathology of glutamate transporters in the central nervous system; molecular mechanisms of brain injury; mechanisms of homeostatic sleep regulation

The findings, published today in the online journal PloS One, open new opportunities for gaining a greater understanding of Alzheimer's disease and other neurological diseases and for developing therapies to halt its progression, according to senior author Karen E. Duff, PhD, professor of pathology (in psychiatry and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) at CUMC and at the New York State Psychiatric Institute.

We will explore whether the intravenous administration of the recombinant protein is able to reduce Aβ accumulation in the mouse brain and prevent the cognitive and behavioral deficits associated with that pathology.

This is the proposal that deposition of amyloid - beta, a major protein ingredient of the plaques that accumulate in the brains of Alzheimerâ $ ™ s patients, is a central event in the pathology of the disease.

«We are proposing that the disease be defined in living people by evidence of brain pathology using biomarker studies, either brain imaging or body fluid examination, and that clinical symptoms should be regarded for what they are — a product or result of the disease, as opposed to the definition of the disease,» said lead author Dr. Clifford Jack, Jr. of the Mayo Clinic.

Tissue - clearing protocols are causing a revolution in human brain pathology.

Jan. 19, 2018 - Researchers have identified evidence of early chronic traumatic encephalopathy (CTE) brain pathology after head impact — even in the absence of signs of concussion.