The normal mice's
brain plaques seemed to be built from human A-beta protein, and the only source of that was the blood of the mutated partner mouse.
Not exact matches
Specifically, rodents genetically modified to express human amyloid precursor protein (hAPP), which can lead to the debilitating
plaques that form in the
brains of Alzheimer's patients,
seem to struggle to find the hidden platform relative to their healthy peers.
It
seems as if antibody drugs used to get rid of sticky
plaques that build up in
brains with Alzheimer's may actually make the disease worse.
The neurological damage
seems to result from deposits in the
brain called amyloid
plaques.
Previously, other researchers reported that ApoE4
seemed to reduce the clearance of amyloid - β, the protein that clumps together to form the hallmark
plaques of AD, from the
brain in a mouse model.
Sleep
seems to be therapeutic and
seems to clear out some of these amyloid
plaques or these toxic proteins that accumulate in the
brain.
Disrupted sleep
seems to be linked to the accumulation of amyloid
plaques inside the
brains of people not having problems with memory.