Sentences with phrase «brain protein expression»

Tuna oil alleviate D - galactose induced aging in mice accompanied by modulating gut microbiota and brain protein expression — Dijun Zhang — Journal of Agricultural and Food Chemistry

Not exact matches

Alternately, The brains of cesarean babies may have impaired expression of the same protein.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

By deleting some of these «ultraconserved elements», researchers have found that these sequences guide brain development by fine - tuning the expression of protein - coding genes.

«Those findings also suggest that FGF21 is regulated the same way in humans as in mice and that the process involves the expression and activation of certain proteins in the brain.»

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

Importantly, patients with mutations in a single copy of NKX2.1 often have Brain - Lung - Thyroid Syndrome, which is characterized by respiratory distress after birth and accompanied by decreased surfactant protein expression.

However, the team was able to show that so - called tight junction proteins, which are known to be important for the blood - brain barrier permeability, did undergo structural changes and had altered levels of expression in the absence of bacteria.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

If a brain is normal, each of those proteins will have one level of expression.

We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using two - dimensional gel electrophoresis.

We identified species - specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.

Notably, the brains of treated fish showed increased expression of genes involved in making ferritin, a protein that stores and transports iron inside cells.

Synaptotrophic defects in mouse brains lacking amyloid precursor protein (APP) expression can be selectively rescued by the non ‐ amyloidogenic APPsα fragment, for which α7 ‐ nAChRs may constitute a physiological receptor.

I am currently exploring functions of BIN1 by generating mouse models to modify the levels of BIN1 expression in the brain, and investigating how altering the levels of this protein can modify AD - related pathophysiology.

«This data allows classification of all human protein - coding genes into those coding for house - hold functions (present in all cells) and those that are tissue - specific genes with highly specialized expression in particular organs and tissues, such as kidney, liver, brain, heart, pancreas.

In this context, Dr. Woo's work focuses on deepening the understanding of these mechanisms based on postmortem human brains and animal studies using a variety of protein and gene expression techniques, in addition to the utilization of differentiated human neurons.

Expression of the familial PD - linked A53T or A30P mutant ASs in cell models results in an increased proportion of CTTAS being produced than is the case when expressing the WT protein; consistent with this, a higher proportion of the total soluble AS in human brain tissue with AS neuropathology is CTTAS, and a higher proportion yet of the total AS in insoluble AS deposits.

Evolutionary divergence of gene and protein expression in the brains of humans and chimpanzees.

The maturation of the brain involves the coordinated expression of thousands of genes, proteins and regulatory elements over time.

A research team led by Fredrik Swartling (Uppsala University / SciLifeLab) has discovered that medulloblastoma, the most common type of malignant brain tumor in children, can be effectively suppressed by combining two treatment strategies, disrupting both the expression and stabilization of the protein MYC.

A series of mouse brain sections is explored for protein expression and distribution in a large number of brain regions.

Inhibition of pSTAT 1 Nuclear Translocation and Antiviral Protein Expression in Human Brain Vascular Adventitial Fibroblasts Infected with Varicella Zoster Virus J Virol.

Our biological studies suggest that a critically reduced amount of this protein alters cell shape, migration, proliferation, and gene expression to the detriment of brain, heart, and kidney development.

However, recent evidence indicates that apoE4 expression compromises the blood - brain barrier (as does apoE deficiency).40 Studies of brain histology, neurodegenerative markers, cholinergic activity, and neuronal function in knockout mice have been equivocal.39 Failure of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate protein.

«Until quite recently, the brain was considered to be an immunologically privileged organ due to the presence of the blood - brain barrier (BBB), the low expression of major histocompatibility complex class II (MHCII) proteins, and the apparent lack of cerebral lymphatic vessels.

Robust changes in expression of brain - derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.