A phase 3 trial of whole
brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320.
This research could have important implications for cancer survivors, given that hypopituitarism is one of the main causes of poor quality of life after
brain radiation therapy.
Treatment approaches include whole -
brain radiation therapy, radiation for individual lesions, and surgery, typically for a single metastasis.
During whole -
brain radiation therapy, beams of radiation cover the entire brain.
Not exact matches
Traditional
therapies for
brain cancer — surgery, chemotherapy and
radiation — haven't been very successful, says Memorial Sloan Kettering's Dr. Baselga, adding, «We have a tremendous need to develop new
therapies, especially with children.»
In December 2017, writing in Computer Methods in Applied Mechanics and Engineering, Yankeelov and collaborators at UT Austin and Technical University of Munich, showed that they can predict how
brain tumors (gliomas) will grow and respond to X-ray
radiation therapy with much greater accuracy than previous models.
Proton
therapy has been shown to be beneficial for certain uncommon ocular and
brain cancers, and especially for treating children like Jonathan, whose developing tissues can be highly sensitive to stray
radiation.
Researchers compared two common postsurgical
therapies for metastatic
brain tumors and found that stereotactic radiosurgery can provide better outcomes for patients compared to whole -
brain radiation.
Although this
therapy does cost more, results often can be achieved in one to three visits compared to 10 to 12 visits for whole -
brain radiation.
Since whole -
brain radiation is associated with significant cognitive effects and the use of additional
radiation therapy for progression is common in this population, the Yale researchers suspect that patients with the ALK mutation would benefit from
radiation focused on individual metastases.
Hypopituitarism can be caused by tumors, genetic defects,
brain trauma, immune and infectious diseases, or
radiation therapy.
In early clinical trials, Sessler and his colleagues treated 39 metastatic
brain tumor patients with texaphyrins 2 hours before
radiation therapy for 10 days.
Researchers at The University of Texas MD Anderson Cancer Center prospectively evaluated the cardiac function biomarkers
brain natriuretic peptide (BNP), troponin - I (TNI), and electrocardiogram (ECG) in 25 patients receiving high - dose conformal
radiation therapy for thoracic malignancies.
He is working closely with a team of physicians at the UNM Cancer Center to conduct these trials: M. Omar Chohan, MD, a neurosurgeon who specializes in surgery for tumors of the
brain and spinal cord; Gregory Gan, MD, PhD, a
radiation oncologist who is an expert in the
radiation therapy of
brain tumors; and Yanis Boumber, MD, PhD, a newly recruited medical oncologist to the UNM Cancer Center who is an expert in cancers of the lung,
brain and spinal cord, and early phase clinical trials.
Unlike adults with
brain cancer, children can not receive
radiation therapy, so doctors must rely on medications and other strategies.
Proton
therapy delivers high
radiation doses directly to the
brain tumor site, with no damage to nearby healthy tissue.
Sophisticated
radiation therapy technologies for treating
brain and spinal tumors, aneurysms, and blood vessel abnormalities while causing minimal damage to healthy tissues.
Proton
therapy is an advanced form of
radiation treatment that is especially effective for reaching tumors or remaining cancer cells close to key organs such as the
brain stem or spinal cord.
Former president Jimmy Carter, who was diagnosed last year with melanoma that had spread to his
brain, announced this month that the double whammy of an immune
therapy drug plus
radiation had been so successful that he was stopping treatment.
For patients with metastatic breast cancer,
radiation therapy can be used to treat areas of distant spread (e.g. bone or
brain).
Dr. Gaspar has 25 years of experience treating thoracic and
brain tumors, utilizing stereotactic techniques, intensity modulated
radiation therapy and image guidance.
Our expert neurologists and neurosurgeons are at the forefront of imaging for
brain surgery, as well as
radiation therapy for
brain, skull and spinal cord tumors and treatments for a wide range of neurologic conditions.
She has worked extensively with concurrent chemotherapy and
radiation therapy for both thoracic and
brain tumors.
Thanks to refined surgical techniques and improved chemotherapy and
radiation therapy, the majority of children with
brain and spinal cord tumors — collectively known as central nervous system tumors — are now long - term survivors.
Newly diagnosed supratentorial
brain lesion compatible with a high grade glioma by MR (magnetic resonance) with no prior treatment with either gene
therapy, chemotherapy or
radiation treatments that is amenable to attempted gross total resection (GTR).
Generally, treatment of metastatic
brain tumors will include surgery, stereotactic radiosurgery, conventional
radiation therapy and chemotherapy, each used independently or in combination.
For example, certain medical
therapies, like
radiation, can damage the
brain and negatively impact memory.
Patients receive a personalized, comprehensive approach to care for their benign and malignant
brain tumors and are evaluated for multimodality treatments such as chemotherapy, minimally invasive surgical options, and
radiation therapy including proton
therapy and gamma knife.
But other studies in mice have shown that a ketogenic diet, when implemented in conjunction with
radiation therapy for the treatment of
brain tumors in mice, resulted in the eradication of these tumors in the majority of the mice.12
Adrienne Scheck has shown that when applied with curative doses of
radiation therapy, the ketogenic diet can make
brain tumors vanish in mice.2 However, many dietary changes appear to blunt cancer growth in mice, 3 and the effects in humans are less clear.
Indications for
radiation therapy (RT) include the primary treatment of specific tumor types, such as nasal tumors and
brain tumors, adjuvant treatment of incompletely excised tumors, and palliation to improve quality of life for patients with non-resectable or advanced cancers.
At the Animal Cancer and Imaging Center, we have treated a large number of patients with
brain tumors with
radiation therapy.
In general,
brain tumor patients treated with
radiation therapy tolerate treatment extremely well.
Three - dimensional CT based
radiation therapy is performed on all
brain tumor patients at ACIC.
Because of this, we usually recommend doing bloodwork, chest X-rays and an abdominal ultrasound to examine your pet for other types of cancer before pursuing any type of
radiation therapy for
brain tumors.
In some tumor locations, especially for suspected
brain tumors, a biopsy diagnosis is not required for consideration of
radiation therapy.
Treatments can range from oral medications given at home to injectable medications given while hospitalized,
brain or spinal cord surgery,
radiation therapy or chemotherapy.
In general, animals tolerate
brain surgery,
radiation therapy, and chemotherapy MUCH better than people, with fewer side effects.