Sentences with phrase «brain samples»

They studied brain samples from mice and rats that were raised with chronic exposure to nicotine and had developed nicotine dependence — similar to a heavy smoker going through two packs a day.

The researchers followed up with an analysis of mouse and human brain samples.

The protocol for collecting frozen brain samples is followed when tissue can be collected within 12 hours of death.

The authors of the new study — a multicenter effort led by Kent State University anthropologists C. Owen Lovejoy and Mary Ann Raghanti and published January 22 in PNAS — began by measuring neurotransmitter levels in brain samples from humans, chimpanzees, gorillas, baboons and monkeys, all of whom had died of natural causes.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

Working with an international group of scientists from Cardiff University, Stanford University and Duke University in addition to screening post-mortem brain samples from the Stanley Medical Research Institute, the scientists are the first to identify a molecular genetic component of the blood brain barrier with the development of schizophrenia.

Further, investigation of these CpG associations revealed nearby genes whose RNA expression was altered in brain samples with Alzheimer's disease: ANK1, CDH23, DIP2A, RHBDF2, RPL13, RNF34, SERPINF1 and SERPINF2.

Observations of reactive microglia in postmortem brain samples of PD patients had led to suggestions that microglia are involved in the neuropathological changes in DA neurons that are inherent to this disease.»

They found that CRF - producing neurons in the VTA were activated during withdrawal, and they examined brain samples from humans, showing that the same CRF - producing VTA neurons are present.

If there is a high suspicion that the animal has rabies, or if an animal showing symptoms of rabies dies suddenly, your veterinarian may recommend submission of the appropriate brain samples for testing.

The researchers analyzed genetic data from autopsied brain samples taken from 1,904 people with neurodegenerative disease.

The investigators examined 21 autopsy brain samples: 12 with HD and nine without.

Increasingly, investigators are also combining brain imaging with studies of human brain samples at autopsy.

They've looked for BMAA in similar brain samples, and haven't seen it.

The researchers analyzed eight Alzheimer's and six healthy brain samples from a brain bank, where people donate their brains after death for medical research.

Structural biologist Robert Tycko, who led the work at the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland, is now looking at many more brain samples from such patients.

The number of plaques in the cerebral cortex per brain sample multiplied in mice engineered to have Alzheimer's.

The team looked for these cells in nonliving brain samples in two ways: molecular markers that tag dividing cells and young nerve cells, and telltale shapes of newborn cells.

The study divides 177 blood and 27 post-mortem brain samples into several groups, establishing that careful analysis of RNA transcripts in blood samples has the ability to distinguish early clinical AD, Parkinson's disease (PD), and cognitively healthy patients.

When they stained brain samples taken from human Huntington's victims, they found that the characteristic globs consist of full - length mutant huntingtin, rather than peptide fragments from the mutant.

By studying brain samples from the mice, the researchers learned how neuregulin 3 works at the cellular level.

Safar says that it has not proved easy to trace brain samples in the United States, but that he is working to do so with the National Institutes of Health and the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia.

Because he was responsible for making the final diagnosis of what killed a patient, he would know which brain samples were from patients with Alzheimer's disease.

All postmortem brain samples come from animals that either died of natural causes or were euthanized for humane reasons due to incurable and / or painful disease.

The brains show no signs of any major disorder, brain samples did not come from drug users or people who used antidepressants either.

The Irish team worked with an international group of scientists from Cardiff University, Stanford University and Duke University, and also screened post-mortem brain samples form the Stanley Medical Research Institute in the US.

De Jager told Alzforum that preliminary data from comparisons between a small number of post-mortem AD brain samples and normal aging brains revealed no striking differences in mCH.

Analyses of amplified bacterial 16 s rRNA sequences disclosed that Proteobacteria was the principal bacterial phylum in all human brain samples with similar bacterial rRNA quantities in HIV and ODC groups despite increased host neuroimmune responses in the HIV group.

He also has a network of dozens of paraveterinary assistants in surrounding villages who keep an ear out for reports of rabid dogs, conduct interviews, and, when possible, take brain samples of dogs suspected to have died of rabies.

Until now, those plaques could be identified only by examining brain samples postmortem.

Thanks to these predictions, the scientists at the CRG together with the team of Fina Martí at IDIBAPS, were able to screen and validate the candidates in vitro (via cell culture), in vivo (with mice), and ex vivo (using human brain samples from dead patients).

Ron Duman and colleagues at Yale University began their search for a mechanism behind depression by comparing post-mortem brain samples from 21 people who had been depressed and 18 people of the same age.

They injected the molecules into mice to create antibodies capable of recognizing the various suspect proteins, and then searched through the antibodies to find those that stuck only to the clumps in brain samples of FTD patients.

The search for more of these factors is complicated by the rarity of brain samples from suicide victims and the lack of an animal model — humans are unique in their wilful ability to end their lives.

Why should the brain sample information in this cyclic fashion?

A team led by geneticist Steven McCarroll of the Broad Institute, based in Cambridge, Mass., combed through genetic information from about 29,000 schizophrenia cases, 36,000 controls and 700 brain samples from deceased patients.

By the time the mouse was 10 months old, it had also lost old plaques, as shown in these brain samples.

VANISHING ACT Globs of a protein linked to Alzheimer's (red) dot a brain sample from a 10 - month - old mouse (left).

In comparison to RNA from healthy brains, more of the RNA from Alzheimer's brain samples was unspliced.

In addition, the researchers looked at brain samples of deceased patients with MS and found increased numbers of GM - CSF - producing cells in comparison to normal brain samples.

(The brain samples, obtained through the Banner Sun Health Research Institute, were taken from a region known to be vulnerable to the most devastating effects of Alzheimer's.)

«Larger numbers of brain samples are required, and future studies should also investigate if bacteria are involved in other neurodegenerative diseases involving neuroinflammation.»

Some scrounging in the basements of the University of Munich has turned up brain samples from the first patient known to be correctly diagnosed with Alzheimer's disease.

The researchers performed proteomic analysis on the brain samples using tandem mass spectrometry, identifying clusters of proteins that seemed to increase or decrease depending on injury severity or time since injury.

The 1 - in - a-billion CAQK peptide (dark blue) also targets injured sites in human brain samples, showing its potential for precise drug delivery.

«Brain samples from great apes, particularly aged individuals, are incredibly scarce, so a study of this size is rare.»

In each of the four brain samples, 4096 spectra were examined in this way.

Analysis of the brain samples for this study began in 2013 in Raghanti's lab at Kent State.

Using postmortem human brain samples, the researchers found that variations in the number of copies of the C4 gene that people had, and the length of their gene, could predict how active the gene was in the brain.