The researchers analyzed genetic data from autopsied
brain samples taken from 1,904 people with neurodegenerative disease.
When they stained
brain samples taken from human Huntington's victims, they found that the characteristic globs consist of full - length mutant huntingtin, rather than peptide fragments from the mutant.
Not exact matches
After
taking samples and conducting
brain scans, the researchers found that 41 percent of mothers of babies with microcephaly tested positive for Zika infection in blood or cerebrospinal fluid
samples, compared with none of those whose babies did not have microcephaly.
This study was conducted in
samples taken from rat
brains, but sleep is thought to induce backward firing in human neurons, too.
(The
brain samples, obtained through the Banner Sun Health Research Institute, were
taken from a region known to be vulnerable to the most devastating effects of Alzheimer's.)
So a team led by autoimmunity researcher and rheumatologist J. Lee Nelson of the Fred Hutchinson Cancer Research Center in Seattle, Washington,
took samples from autopsied
brains of 59 women who died between the ages of 32 and 101.
Researchers most commonly study the effect of antidepressants using a technique known as microdialysis, in which they insert a probe into the
brain to
take tiny chemical
samples from the tissue.
But these previous studies looked at average levels of methylation within a
sample of each insect type —
taking, for instance, a group of worker ants, mixing their DNA together, and measuring the average amount of methylation among all their
brains.
She and colleagues examined DNA from individual
brain cells
taken from three donated human
brains and tested bulk
samples from the hippocampus (an area important for learning and memory) and the frontal cortex (where most thinking and decision making is thought to happen).
George decided to
take a closer look at the VTA and worked closely with Paul Sawchenko, professor at the Salk Institute who was part of the group that originally discovered CRF, to use radioactive RNA markers to detect CRF in
brain samples from rodents.
They used state - of - the - art DNA sequencing technology to screen for retrotransposons in tissue
samples taken postmortem from three individuals who were healthy when alive and had no neurological disease or signs of abnormality in their
brain tissue.
To verify the findings, additional tests were then carried out on
samples taken from the
brains of rats.
The researchers analyzed the concentrations of 5,713 different lipids, or fat molecules and their derivatives, present in
samples of
brain, kidney and muscle tissues
taken from humans, chimpanzees, macaques and mice.
He also has a network of dozens of paraveterinary assistants in surrounding villages who keep an ear out for reports of rabid dogs, conduct interviews, and, when possible,
take brain samples of dogs suspected to have died of rabies.
There are many more glial cells in the
brain than neurons, and astrocytes are the most abundant of the glia, so if you
take a
sample of
brain tissue, you're fairly sure to get some astrocytes as part of the bargain.
For example, it could
take nearly two months to image an entire mouse
brain with a 20x / 1.0 NA objective with proper
sampling.
Simply
take a
sample of the
brain, count the number of neurons in that
sample and then extrapolate that information to account for the remaining
brain volume.
Tissue
samples from 286 autopsied
brains were
taken to measure
brain metal concentrations.
In an experiment involving
samples of
brain tissue
taken from rats, the study's authors found that antioxidants in catuaba may help prevent ischemia by reducing oxidative stress.
«In this study, we scanned people's
brains before and after the retreat, as well as
took blood
samples at the beginning of the study before the retreat, and then four months later,» says Emily Lindsay, Ph.D. student at Carnegie Mellon University and lead study author.
Given their typical age of onset, a broad range of mental disorders are increasingly being understood as the result of aberrations of developmental processes that normally occur in the adolescent
brain.4 — 6 Executive functioning, and its neurobiological substrate, the prefrontal cortex, matures during adolescence.5 The relatively late maturation of executive functioning is adaptive in most cases, underpinning characteristic adolescent behaviours such as social interaction, risk
taking and sensation seeking which promote successful adult development and independence.6 However, in some cases it appears that the delayed maturation of prefrontal regulatory regions leads to the development of mental illness, with neurobiological studies indicating a broad deficit in executive functioning which precedes and underpins a range of psychopathology.7 A recent meta - analysis of neuroimaging studies focusing on a range of psychotic and non-psychotic mental illnesses found that grey matter loss in the dorsal anterior cingulate, and left and right insula, was common across diagnoses.8 In a healthy
sample, this study also demonstrated that lower grey matter in these regions was found to be associated with deficits in executive functioning performance.