Fredrik Swartling's group at Uppsala University / SciLifeLab and Olle Sangfelt group at Karolinska Institutet have jointly discovered that the usually protective protein FBW7 is commonly mutated and inactivated
in brain tumor cells in children.
Again, using mouse models of glioblastoma — this time created
from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.
Authored and submitted a paper for publication, «The Behavior
of Brain Tumor Cells Extracted From the Pineal Gland Under Spectrum Shifts of UV Light»
Dendritic cells are too large to pass through the blood - brain barrier, which is one reason they have to be cultured
with brain tumor cells outside the body, then injected back into the patient's skin as a vaccine.
Encapsulated toxin - producing stem cells (in blue) help
kill brain tumor cells in the tumor resection cavity (in green).
Ringer's lactate solution (Lactec) was irradiated with plasma for 3 - 5 minutes, after which it demonstrated anti-tumor effects
on brain tumor cells.
In a new study, Yale Cancer Center researchers identified a novel genetic defect that
prevents brain tumor cells from repairing damaged DNA.
In experiments in animals, researchers from the University of Michigan Medical School showed that adding rapamycin to an immunotherapy approach strengthened the immune response
against brain tumor cells.
As part of the research, Castro and her colleagues determined that
brain tumor cells use the mTOR pathway to hamper the immune response of patients.
A new study describes how hypoxia induces stem - like characteristics in
brain tumor cells through the modulation of the chromatin environment of pluripotency - associated genes
Using multiple imaging markers, it was possible to watch the virus as it passed from the stem cells to the first layer
of brain tumor cells and subsequently into all of the tumor cells.
Dr. Del Maestro adds, «Yong and colleagues at the University of Calgary have begun to unravel the complex interaction of the microglia with
the brain tumor cells, resulting not only in furthering our understanding, but providing a new concept and drug which can now be immediately assessed in clinical trials.»
Known as a PARP inhibitor, the drug acts on a defect in the DNA repair mechanism in
the brain tumor cells, they said.
First step, they stimulated the body's own immune system in such a way that it recognized and then killed
the brain tumor cells even in advanced stages of the disease.
In laboratory experiments the researchers mimicked the way SOX9 is stabilized in
brain tumor cells and showed how SOX9 turned on 40 to 50 genes in the tumor to make it more resistant to chemotherapy and more prone to spread.
Other studies have shown that a compound in black seeds and oil, Thymoquinone, helps induce apoptosis (cell death) in leukemia cells (4) and other studies have shown this same effect in breast cancer cells (5),
brain tumor cells (6), pancreatic cancer, cervical cancer, and even oral cancer cells and cavity forming bacteria (7).