Sentences with phrase «brain tumor model»

In a new paper in Science Translational Medicine, the U-M team describes how they developed a novel brain tumor model in mice.

«We report much higher therapeutic efficacy in preclinical brain tumor models using the combination of both therapies, leading to an increase in median survival,» Lowenstein says.

The next stage of research conducted by Prins and Liau will verify these findings in other brain tumor models.

This evolutionary and metabolic approach to brain cancer management is supported from studies in orthotopic mouse brain tumor models and from case studies in patients.

Not exact matches

In December 2017, writing in Computer Methods in Applied Mechanics and Engineering, Yankeelov and collaborators at UT Austin and Technical University of Munich, showed that they can predict how brain tumors (gliomas) will grow and respond to X-ray radiation therapy with much greater accuracy than previous models.

Model of tumor growth in a rat brain before radiation treatment (left) and after one session of radiotherapy (right).

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

«Lower - carb diet slows growth of aggressive brain tumor in mouse models.»

In addition to discovering this mechanism, Yong and Sarkar also identified a drug — amphotericin B (AmpB)-- to reactivate microglia that in an animal model, showed a significant reduction in brain tumor growth.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

The researchers took this discovery and, in an animal model, identified a drug that is able to re-activate those immune cells and reduce brain tumor growth, thereby increasing the lifespan of mice two to three times.

In a model of glioblastoma, a brain cancer that does not metastasize outside of the brain, they could readily see that the length of circulating tumor DNA was smaller than healthy DNA by 20 - 50 base pairs.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

Knocking down the expression of either the fruit fly version of the FOXD1 gene or the fruit fly version of ALDH1A3 blocks the formation of brain tumors in a brain cancer model of the fruit fly species Drosophila melanogaster, the researchers found.

Sanford Research scientists are published in Nature Cell Biology for their work developing a model to explore therapies for a pediatric brain tumor known as choroid plexus carcinoma.

«Animal model for pediatric brain tumor created.»

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

Rubin used a cell model of glioblastoma to prove it is easier to make male brain cells become tumors.

In their search for novel, tumor - specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed a mouse model that more closely mimics what is seen in patients.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

They found that injecting patient - derived, brain - seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients.

Brain Tumor, Pediatric High Grade Gliomas, Histones, Epigenome, Cancer Genomics, Giant Cell Tumors of the Bone, Animal Models

«This is exciting because it's the first animal model of pediatric high - grade gliomas, or malignant brain tumors,» says Maria Castro, Ph.D., senior author of the paper and a professor in the departments of Neurosurgery and Cell and Developmental Biology at U-M.

Researchers at Uppsala University have used computer modeling to study how brain tumors arise.

«We are very excited about this tumor model as it mimics the developmental environment of a pediatric or adolescent human brain tumor,» he says.

In addition to developing the new genetically engineered mouse model for the form of cancer called glioblastoma multiforme, the researchers made a key discovery about brain tumor biology via the mice.

Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model.

[31] Animal brain metastasis models have demonstrated significant tumor response and improved survival with this compound.

Characterization of passive permeability at the blood — tumor barrier in five preclinical models of brain metastases of breast cancer.

Biocellion is being used to model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics in complex soil structure, brain tumor growth and invasion, formation of complex bacterial colonies, and changes in blood vessels and skin cells.

The lab has examined MRI cell tracking in animal models of dysmyelination, multiple sclerosis, brain tumors, spinal cord, stroke, and diabetes.

Most xenograft models for brain tumors using tumor cell lines require at least 10,000 cells.

In the latest issue of the magazine EBioMedicine researchers at SciLifeLab / Uppsala University present a biobank with cell lines that can be used as models for brain tumors.

Block of purinergic P2X7R inhibits tumor growth in a c6 glioma brain tumor animal model.

It is not unreasonable to assume that the dog will be a highly useful model of human brain tumors.»