This evolutionary and metabolic approach to brain cancer management is supported from studies in orthotopic mouse
brain tumor models and from case studies in patients.
The next stage of research conducted by Prins and Liau will verify these findings in other
brain tumor models.
«We report much higher therapeutic efficacy in preclinical
brain tumor models using the combination of both therapies, leading to an increase in median survival,» Lowenstein says.
In a new paper in Science Translational Medicine, the U-M team describes how they developed a novel
brain tumor model in mice.
Not exact matches
In December 2017, writing in Computer Methods in Applied Mechanics and Engineering, Yankeelov and collaborators at UT Austin and Technical University of Munich, showed that they can predict how
brain tumors (gliomas) will grow and respond to X-ray radiation therapy with much greater accuracy than previous
models.
Model of
tumor growth in a rat
brain before radiation treatment (left) and after one session of radiotherapy (right).
In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse
models of breast and lung cancer — two
tumor types that often spread to the
brain — many cancer cells that enter the
brain are killed by astrocytes.
«Lower - carb diet slows growth of aggressive
brain tumor in mouse
models.»
In addition to discovering this mechanism, Yong and Sarkar also identified a drug — amphotericin B (AmpB)-- to reactivate microglia that in an animal
model, showed a significant reduction in
brain tumor growth.
Again, using mouse
models of glioblastoma — this time created from
brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.
Engineered human immune cells can vanquish a deadly pediatric
brain tumor in a mouse
model, a study from the Stanford University School of Medicine has demonstrated.
They cross the blood -
brain / blood -
tumor barrier, and accumulate within
brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce
tumor burden and prolong survival in our mouse
models.»
The researchers took this discovery and, in an animal
model, identified a drug that is able to re-activate those immune cells and reduce
brain tumor growth, thereby increasing the lifespan of mice two to three times.
In a
model of glioblastoma, a
brain cancer that does not metastasize outside of the
brain, they could readily see that the length of circulating
tumor DNA was smaller than healthy DNA by 20 - 50 base pairs.
To test this idea, the researchers utilized two mouse
models of human breast cancer metastasis and found dormant disseminated
tumor cells residing upon the membrane microvasculature of lung, bone marrow and
brain tissue.
Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse
models of glioblastoma, the most common
brain tumor in human adults.
Knocking down the expression of either the fruit fly version of the FOXD1 gene or the fruit fly version of ALDH1A3 blocks the formation of
brain tumors in a
brain cancer
model of the fruit fly species Drosophila melanogaster, the researchers found.
Sanford Research scientists are published in Nature Cell Biology for their work developing a
model to explore therapies for a pediatric
brain tumor known as choroid plexus carcinoma.
«Animal
model for pediatric
brain tumor created.»
A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that
model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.
Rubin used a cell
model of glioblastoma to prove it is easier to make male
brain cells become
tumors.
In their search for novel,
tumor - specific therapies that could target multiple
brain metastases without damaging adjacent tissues, the research team first developed a mouse
model that more closely mimics what is seen in patients.
After first verifying that stem cells injected to the
brain would travel to multiple metastatic sites and not to
tumor - free areas in their
model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..
They found that injecting patient - derived,
brain - seeking melanoma cells into the carotid artery of these preclinical
models resulted in the formation of many metastatic
tumors throughout the
brain, mimicking what is seen in advanced melanoma cancer patients.
Brain Tumor, Pediatric High Grade Gliomas, Histones, Epigenome, Cancer Genomics, Giant Cell
Tumors of the Bone, Animal
Models
«This is exciting because it's the first animal
model of pediatric high - grade gliomas, or malignant
brain tumors,» says Maria Castro, Ph.D., senior author of the paper and a professor in the departments of Neurosurgery and Cell and Developmental Biology at U-M.
Researchers at Uppsala University have used computer
modeling to study how
brain tumors arise.
«We are very excited about this
tumor model as it mimics the developmental environment of a pediatric or adolescent human
brain tumor,» he says.
In addition to developing the new genetically engineered mouse
model for the form of cancer called glioblastoma multiforme, the researchers made a key discovery about
brain tumor biology via the mice.
Metastasis of Breast
Tumor Cells to
Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis
Model.
[31] Animal
brain metastasis
models have demonstrated significant
tumor response and improved survival with this compound.
Characterization of passive permeability at the blood —
tumor barrier in five preclinical
models of
brain metastases of breast cancer.
Biocellion is being used to
model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics in complex soil structure,
brain tumor growth and invasion, formation of complex bacterial colonies, and changes in blood vessels and skin cells.
The lab has examined MRI cell tracking in animal
models of dysmyelination, multiple sclerosis,
brain tumors, spinal cord, stroke, and diabetes.
Most xenograft
models for
brain tumors using
tumor cell lines require at least 10,000 cells.
In the latest issue of the magazine EBioMedicine researchers at SciLifeLab / Uppsala University present a biobank with cell lines that can be used as
models for
brain tumors.
Block of purinergic P2X7R inhibits
tumor growth in a c6 glioma
brain tumor animal
model.
It is not unreasonable to assume that the dog will be a highly useful
model of human
brain tumors.»