Researchers studying
the brain tumor type glioma often use a cell line called U87MG that was established at Uppsala University almost fifty years ago.
C.S. Mott Children's Hospital has expertise in treating the full range of pediatric
brain tumor types, including:
Not exact matches
Novocure's main focus to date has been treating glioblastoma, or GBM, a
type of
tumor that affects the
brain.
In 2009 he had been diagnosed with a
type of rapidly growing
brain tumor called a high - grade astrocytoma that, despite aggressive treatment, eventually evolved into a glioblastoma — the highly malignant
brain tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.
Yet since 1985, there have been only four FDA - approved drugs to treat the more than 120 different
types of
brain tumors, according to the National Brain Tumor Soc
brain tumors, according to the National
Brain Tumor Soc
Brain Tumor Society.
Glioblastoma remains one of the most difficult
types of
brain tumors to treat successfully.
While it has shown promise for some
types of
tumors and become standard of care for others, researchers are just beginning to explore how different immunotherapy technologies can be applied to
brain cancer.
Sen. John McCain of Arizona last week revealed he is battling glioblastoma, the most common and aggressive
type of malignant
brain tumor in adults.
But one
type of childhood
brain tumor has stymied efforts to identify a recurring genetic defect.
Brain tumors are the most common
type of solid cancer in children, but they're still poorly understood,» Venneti says.
According to the American
Brain Tumor Association, this type of tumor is the most common in adults, affecting as many as 300,000 people each
Tumor Association, this
type of
tumor is the most common in adults, affecting as many as 300,000 people each
tumor is the most common in adults, affecting as many as 300,000 people each year.
In the Cell study, Dr. MassaguĂ©, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two
tumor types that often spread to the
brain — many cancer cells that enter the
brain are killed by astrocytes.
Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable
type of
brain tumor.
Researchers from the University of Southampton have discovered a potential way of stopping one of the most aggressive
types of
brain tumor from spreading, which could lead the way to better patient survival.
Glioblastoma is one of the most common
types of malignant
brain tumors in adults.
An international team of researchers has identified eight additional
types of cancer linked to excess weight and obesity: stomach, liver, gall bladder, pancreas, ovary, meningioma (a
type of
brain tumor), thyroid cancer and the blood cancer multiple myeloma.
Baliga's group is also mapping networks in patients with glioblastoma, a particularly deadly
type of
brain tumor.
The study looked for two of the most common
types of
brain tumors — gliomas, which are often malignant, and meningiomas, which are more often benign — in people ages 20 to 79 in Denmark, Finland, Norway and Sweden between 1974 and 2003.
Glioblastoma is the most aggressive
type of
tumor that originates in the
brain and with no curative treatments currently available, the average survival time for patients ranges from 15 to 18 months.
Second, we believe the vaccine may be particularly beneficial for a group of patients with the HLA - A2
type, which suggests that as we move forward, there may be advantages in targeting this population,» said John Yu, MD, vice chair of the Department of Neurosurgery, director of surgical neuro - oncology, medical director of the
Brain Tumor Center and neurosurgical director of the Gamma Knife Program at Cedars - Sinai.
Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common
type of
brain cancer called glioblastoma multiforme, a
tumor of the glial cells in the
brain.
In the United States, the ABI is approved for use only in patients 12 years or older with neurofibromatosis
type II, an inherited disease that causes a non-malignant
brain tumor on the hearing nerve, but it has shown limited effectiveness in adults.
«First drug target identified for children with rare
type of
brain tumor.»
Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly
type of
brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive
tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.
Patients were stratified by number of
brain metastases (1 vs. 2 - 3), primary cancer
type (melanoma vs. other histology) and pre-operative
tumor size (less than vs. greater than three centimeters).
In a report on one of the two findings, published online Sept. 20 in Acta Neuropathologica, the investigators identified alterations in a protein known as ATRX in human
brain tumors that arise as part of a genetically inherited condition known as neurofibromatosis
type 1 (NF1).
Researchers investigating pediatric low - grade gliomas (PLGG), the most common
type of
brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer.
The screening revealed coibamide A to be capable of killing many
types of cancer cells, but Ishmael decided to focus subsequent studies on two
types in particular —
brain tumors, or glioblastomas, and a breast cancer subtype known as triple negative breast cancer.
One challenge in developing drugs to fight
brain tumors is that agents must be able to cross the blood -
brain barrier, a filtering mechanism that only allows certain
types of substances to enter the
brain.
A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model
brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat
types of cancer.
In people under age 30, radiation is a risk factor for a
type of
brain tumor called a meningioma, a Loyola University Medical Center study has found.
Different
types of
tumors show a preference for specific organs and tissues; circulating breast cancer cells, for example, are likely to take root in bones, lungs, and the
brain.
That genetic map led to key insights, such as the link between glioblastoma, the deadliest
type of
brain tumor, and a gene called BEX1.
Dario C. Altieri, M.D., Wistar's President and CEO and lead author of the study, and colleagues showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas — a
type of
brain tumor — and how the pathway could be a valuable therapeutic target in cancer.
Injected into rodents, the cells don't form
tumors; rather, they migrate through the animals»
brains, where they differentiate into various
types of neural cells including the cells that create the myelin that protects nerve fibers.
The study was carried out in mice to mimic a common
brain tumor arising in a genetic condition called neurofibromatosis
type 1 (NF1).
The activation of this signaling pathway progressively increased in different
types of gliomas, with the highest activity seen in patients with glioblastoma, a particularly difficult - to - treat form of
brain cancer that represents approximately 15 percent of all
brain tumors.
Cancer researchers have found that certain
types of dental X-rays significantly increased the incidence of the most common
type of
brain tumor in the United States: meningioma.
While most
types of primary
brain cancer may spread within the
brain, it is rare for a primary
brain tumor to spread outside the
brain.
Molecular testing: Some primary
brain tumors, including some of the most common
types of gliomas, are defined by their key molecular features resulting from
tumor cell mutations.
A germinoma is a
type of germ cell
tumor that is most commonly found in the
brain.
In some cases, for example with a
type of
brain tumors called gliomas, it is not even known yet.
The study conducted at SciLifeLab shows that temozolomide itself not only is cytotoxically active against glioblastoma
tumors but also against other
types of
brain tumors, such as medulloblastoma and metastases from other primary
tumors.
Examples include medulloblastoma and glioblastoma,
types of
brain tumor, retinoblastoma, a
tumor in the retina of the eye, osteoblastoma, a
type of bone
tumor, and neuroblastoma, a
tumor of the nervous system found in children.
LA JOLLA, CA — Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive
type of primary
brain tumor, begins in glial cells that make up supportive tissue in the
brain...
Brain tumor treatments — and outcomes — are related to the
type of
tumor, the location of the
tumor within the nervous system, and other factors.
A research team led by Fredrik Swartling (Uppsala University / SciLifeLab) has discovered that medulloblastoma, the most common
type of malignant
brain tumor in children, can be effectively suppressed by combining two treatment strategies, disrupting both the expression and stabilization of the protein MYC.
The most common
types of cancer in children under the age of 15 are acute lymphocytic leukemia,
brain tumors, neuroblastoma, and non-Hodgkin lymphoma, while the most common
types in adolescents between the ages of 15 - 19 are Hodgkin lymphoma, thyroid carcinoma,
brain cancer, and testicular germ cell
tumors.
We identify and advance therapeutics into clinical trials for children with
brain cancer, with increasing focus on
types of
brain tumors that are uncommon and have the greatest need for translational research.
He continues to study cancer gene function in his Georgetown lab, and has recently identified a new cancer gene called STAG2 that is among the most commonly mutated genes in cancer, involved in causing bladder cancer, pediatric bone
tumors, leukemias,
brain tumors, and other
tumor types.