Even when the investigators removed the scans of 16 participants who were dependent on alcohol as well as cocaine, the link between cocaine use and
brain volume loss remained.
Brain volume loss in antibody responders was not significantly different from placebo - treated patients approximately 3.6 years from the end of the original study.
Now we need to investigate whether these structural changes correlate with reduced cognitive function and whether neuroprotective strategies might be able to stop the progression
of brain volume loss.
Of the small number of patients who underwent a follow - up MRI, antibody responders showed
similar brain volume loss during the follow - up period subsequent to the AN1792 phase 2a study compared with placebo - treated patients.
Subacute normobaric oxygen and hyperbaric oxygen therapy in drowning, reversal
of brain volume loss: a case report — Paul G Harch — Medical Gas Research