Sentences with phrase «brains of adult mice»

And a study published Aug. 18 that was conducted in part by the La Jolla Institute of Allergy and Immunology revealed it's not just kids who could be at risk, after results found Zika affected the brains of adult mice.

The findings revealed that prenatal exposure to a commonly used antiepileptic drug called valproic acid (VPA) inhibited the birth of new neurons in the brains of adult mice and impaired their performance on learning and memory tasks.

Using a small fragment of apolipoprotein B as a guide, Brian Spencer, a postdoctoral fellow in the Verma lab and the study's lead author, successfully shepherded the enzyme glucocerebrosidase into the brains of adult mice.

This botanically named cell, discovered in the brains of adult mice, made its formal debut in the Nov. 27 Science.

«Youthful plasticity restored to brains of adult mice.»

Not exact matches

The researchers then used genetic techniques to find out what would happen when NAD manufacturing is turned off in the adult neural stem cells of the mouse brain.

Research published in the October 21 issue of Science Translational Medicine uses a virus to deliver an extra dose of the gene p11 to the adult mouse brain.

An Ludwig - Maximilians - Universitaet (LMU) in Munich study reveals that sound - evoked activity of neurons in the auditory system of the mouse increases the thickness of their myelin sheaths — and enhances the speed of signal transmission — both during development and in the adult brain.

They found that dendrites in adult mouse brains were studded with long spines, a hallmark of immature neurons.

These two MRI images show details of an adult mouse brain, including the optic nerves, the cerebral cortex, the cerebellum, and the brain stem.

Curiously, the researchers discovered that only about five percent of the stem cells injected into the brain - addled mice matured into adult neurons.

Researchers showed that limiting the supply or the function of the neuromodulator adenosine in a brain structure called the auditory thalamus preserved the ability of adult mice to learn from passive exposure to sound much as young children learn from the soundscape of their world.

Adult mice and other rodents sprout new nerve cells in memory - related parts of their brains.

To test potential brain repair strategies, Berninger and Magdalena Götz of Ludwig - Maximilians University Munich delivered transcription factors into the cerebral cortex of adult mice three days after traumatic injury.

When the scientists recently gave mice a single dose of cocaine and looked for signs of autophagy in their brain cells, they detected autophagy - associated proteins and changes in vacuoles in adults and in mouse pups whose mothers had received cocaine while pregnant.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

In a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampus.

The scientists focused on the production of new neurons in adult mice, in particular those neurons that integrate into the olfactory bulb, the brain region responsible for analyzing odors.

To track down the source of the new cells, Doetsch injected adult mouse brains with an anticancer compound that selectively kills rapidly dividing cells but leaves mature cells alone.

In separate experiments in adult female mice with no pups — and hence no experience with elevated oxytocin levels — adding extra oxytocin into their «virgin» brains led these mice to quickly recognize the barely audible distress calls of another mother's pups recently removed from their home nest.

They injected live brain cells from mouse embryos into the amygdalae of adult mice — the parts of the brain involved in fear.

Yong - Chun Yu at Fudan University in Shanghai, China, and his team wondered if fearful adult mice could be helped by a transplant of embryonic brain cells.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

A group of scientists led by Sebastian Jessberger of the Brain Research Institute showed now that also the stem cells of the adult mouse brain asymmetrically segregate aging factors between the mother and the daughter cBrain Research Institute showed now that also the stem cells of the adult mouse brain asymmetrically segregate aging factors between the mother and the daughter cbrain asymmetrically segregate aging factors between the mother and the daughter cells.

Conversely, adolescent mice with increased eIF2α activity in the brain became more resistant to the effects of cocaine, as seen in adults.

Reticulon 4 receptor (RTN4R): Lowered levels of RTN4R can increase plasticity in the adult brain in mice, improving recovery from brain injury and increasing the ability to learn new tasks.

Benedetta Artegiani (Calegari, TUD)-- «A Transitory Overexpression of Cdk4 / CyclinD1 Triggers a Greater Expansion of Neural Stem Cells and Neurons in the Adult Mouse Brain» (2012)

Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain.

GIND investigator Li Gan, PhD, and her collaborators studied the development of neurons born in the hippocampus of adult mice genetically engineered to produce high levels of human Aβ in the brain.

These mice developed hallmark signs of PD in their brains and behavior: loss of dopaminergic neurons in the SNc, impaired generation of new neurons in one of the few regions capable of producing them in adult organisms, and impaired muscle coordination similar to human victims of Parkinson's (as evidenced by difficulty in rearing up on their hind legs)(Figure 2).

The team used genetically engineered mice to study the effects of different human apoE variants on the maturation of neural stem cells or progenitor cells, from which new neurons develop in the adult brain.

The complete mouse brain profile is represented by serial coronal sections of adult mouse brain, 16 µm thick.

To do this, a group of researchers recently used genetic techniques to remove huntingtin from adult mice of different ages, then studied their brains and behavior until old age.

The scientists also will look at the effects of brain cholesterol deprivation in adult mice, in addition to mice born with the modification.

B or AAV9 (as a control) into different adult mice and after three weeks used the amount of green fluorescence to assess the efficacy with which the viruses entered the brain, the spinal cord, and the retina.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

We have previously shown ex-vivo its beneficial effect on synaptic transmission and plasticity in a mouse model of the OPHN1 loss of function.Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1 - / y However, deficits in working and spatial memories are partially or not rescued by the treatment.

Briefly, whole hemispheres of WT adult (4 mo) or WT young (P16 — P20) mouse brains were frozen in molds filled with optimum cutting temperature (OCT) embedding matrix (Tissue - Tek).

Here, we show that BACE2 is expressed in discrete subsets of neurons and glia throughout the adult mouse brain.

The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.