Sentences with phrase «brains of mice»

«Autism may begin early in brain development: Brains of mice with autism - like symptoms develop neural defects when first circuits take shape.»
However, when Ulrich Mueller at the Scripps Research Institute in La Jolla, California, and his colleagues studied the developing brains of mouse embryos, they found that neurons in the upper layers of the cortex are produced by a different type of stem cell (Science, DOI: 10.1126 / science.1223616).
To remedy this, Donato pioneered a strategy that allowed his team to find the neurons responsible for building the entorhinal - hippocampal region targeted toward the developing brains of mice at specific time points.
Peter Scheiffele at the University of Basel, Switzerland, and colleagues used microscopes to view the developing brains of mice engineered so that individual neurons and their connections showed up in different colours.
However, when Mueller and his colleagues studied the developing brains of mice embryos, they found that neurons in the upper layers of the cortex are produced by a different type of stem cell.
The team also detected Zika virus in the fetal brains of mice, and that infection was associated with fetal weight loss.
But accurately reproducing a human mental illness in the tiny brain of a mouse is still hugely challenging.
By 2011 they hope to create a second - generation Neurogrid containing 64 million silicon neurons, about equal to the total brain of a mouse.
With the flick of a chemical switch, researchers can now exert unprecedented control over the activity of molecules that help wire the developing brains of mice.
Accordingly, the team also saw axonal varicosities in the brains of mice subjected to repeated light blows to the head.
The authors of the study referenced in the article found there was no causal connection between light and cell division in the brain of mice if they had artificial light shined at them at one - hour intervals.
In this study, the researchers stimulated specific areas in the brains of mice and recorded the evoked brain activity.
MIT neuroscientist Susumu Tonegawa has pulled up silent engrams — memories that aren't readily accessible — from the brains of mice with signs of Alzheimer's disease, Sanders says.
Beta - amyloid protein is found in the brains of mice and humans.
Boulanger recently found that decreasing the level of the MHC class I molecules in the bodies and brains of mice was sufficient to cause biochemical and behavioral symptoms of autism and schizophrenia in the mice.
The group isolated a small group of neurons in the brains of mice that play a critical role in persistent behavior, according to a study published today in Science.
To investigate, Walker Jackson of the Whitehead Institute in Boston, Massachusetts, and his colleagues created mice with a mutation associated with the human prion disease Fatal Familial Insomnia and injected some of their brain tissue into the brains of mice without the mutation.
Caubit's team examined the brains of mouse embryos lacking the gene and found that neurons of the respiratory rhythm generator (RRG)-- a kind of pacemaker that produces an rhythm in the brainstem and controls autonomous breathing — had not developed properly (The Journal of Neuroscience, DOI: 10.1523 / jneurosci.1765 - 10.2010).
The brains of the mice that got only LPS had fewer dendrites attached to their neurons.
With the help of viruses, the researchers introduced fluorescing molecules in the brains of mice and these molecules always glowed when the production of the special calcium ion channel was activated.
Green and co-workers worked out a gentler approach using druglike molecules to kill microglia in the brains of mice with simulated Alzheimer's disease.
Using «freshman physics,» neuroscientists have deployed electric fields to stimulate neurons buried deep in the brains of mice — a method that could one day lead to noninvasive therapies for people with Parkinson's disease and other brain disorders.
When the brains of the mice were examined via immunostaining after treatment, the animals had, on average, a few dozen cancer cells left, compared with tens of thousands of cancer cells in animals that received a control treatment.
When pointed at the brains of mice, such vibrations might loosen the seals between the cells of the blood vessels inside, she suspected.
After imaging defiant metastatic cells in the brains of mice, researchers noticed that the cells that were able to survive grew on top of blood capillaries, each cell sticking closely to its vessel «like a panda bear hugging a tree trunk,» Dr. Massagué says.
The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.
It reveals specialized cells in the brains of mice dividing to create newborn nerve cells.
Other researchers have used optogenetics to transmit artificial skin sensations into the brains of mice, but Ko plans to investigate other technologies to find a technique that's best suited for his lab's e-skin.
Instead of galaxies and stars, the scientists analysed 3 - dimensional images of the astrocytes inside the brains of mouse models of Alzheimer's disease.
By examining the brains of these mice, the researchers observed a substantial decrease in inhibitory CA2 neurons, as compared to a control group of normal, healthy mice — a change remarkably similar to that previously observed in postmortem examinations of people with schizophrenia.
The idea the Alzheimer's can spread through the brain first gained support a few years ago when Duff and other Columbia researchers discovered that tau spread from neuron to neuron through the brains of mice.
The researchers used a technique called laser scanning photostimulation to map the connections between individual subplate neuron cells in the brains of the mouse pups.
Two team members, Abid Hussaini, PhD, and Gustavo Rodriguez, PhD, showed that stimulating the activity of neurons accelerated the spread of tau through the brain of mice and led to more neurodegeneration.
After a year, the brains of the mice carrying the mutations were full of A-beta plaques, as expected.
The brains of mice mutated to produce large amounts of amyloid - beta developed plaques (arrowheads, right).
Remarkably, when they activated these neurons using light in one mouse, even in the absence of stress, the brain of the mouse receiving light and that of the partner were changed just as they would be after a real stress.
«When we injected this small piece of the virus glycoprotein into the brain of mice, the mice started running around much more than mice that got a control injection,» he said.
He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.
The group has managed to completely simulate the brain of a mouse (512 processors), rat (2,048) and cat (24,576).
In one of the experiments, Hueffer and his colleagues injected a small piece of the rabies virus glycoprotein into the brains of mice.
In a paper published in Nature Immunology in 2011, Dr. Rostami and colleagues showed that the Th - 17 cells also produced another cytokine called GM - CSF, which created a chain reaction with another cell type ultimately increasing the GM - CSF levels in the brain of mouse models significantly.
Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal.
Intriguingly, in the new study, the brains of mice modeling autism that were fed the high - glycemic index diet had drastically less doublecortin, a protein indicator of newly developing neurons, compared to predisposed mice on the low - glycemic index diet.
To then see what MBP would do once it got to the brain, Daniell and colleagues exposed the CTB - MBP protein to the brains of mice bred to have an Alzheimer's disease.
The brains of mice genetically modified to lack normal prion proteins had significantly higher beta - amyloid levels.
To investigate further, the researchers looked for changes in the brains of the mice.
The brains of mice fed a high glycemic index diet have greater numbers of activated immune cells (shown in red and green) called microglia.
Researchers injected the modified virus into the brains of mice and waited for four weeks — giving cells inside the rodents» brains time to produce antibodies from the introduced code.
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