Sentences with phrase «brains of mice at»

By labeling and collecting samples of Lynx1 and its precursors from the brains of mice at different ages, the researchers tracked how its levels changed over time.

Not exact matches

The authors of the study referenced in the article found there was no causal connection between light and cell division in the brain of mice if they had artificial light shined at them at one - hour intervals.

Mishra's previous work at the National Institutes of Health established that, in mice, BNP is involved in transmitting itching sensations from the skin to the brain.

Compared with mice with cells from healthy people as well as non-chimera mice, those whose brains had human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering, and more sleepless — all of which characterize people with schizophrenia, too.

At day 10, they researchers detected a 70 percent reduction of SMN lnc - RNA in the brains of treated mice, but survival, body weight and the ability to get on their feet wasn't improved compared to mice injected with saline.

Most recently, he noted, researchers reported in Science that sleep functions as a kind of «sewer system» for the brain, at least in mice, by flushing beta - amyloid, which is known to accumulate in the brains of patients with Alzheimer's disease.

In 2015, Noebels and Dr. Isamu Aiba, a research fellow in neurology at Baylor, published a paper in Science Translational Medicine in which they described in a mouse model what would happen if spreading depolarization, the blackout of brain activity, occurred deep in the brainstem, which controls the heart beat and breathing.

Alcino Silva, distinguished professor of psychology at UCLA, has been using genetic markers and a highly miniaturized microscope to zero in on sets of brain cells in mice with such interconnected or «linked» memories.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

To probe this gene's role in brain development, Greenough's collaborators at the University of Amsterdam and at Erasmus University in Rotterdam, the Netherlands, knocked out the gene in mice.

Researchers at Hebrew University in Jerusalem and the Israeli Defense Force's Medical Corps have found that a variety of chemicals penetrate the mouse blood - brain barrier much more readily when the mice are forced to tread water, a condition that induces stress.

So Yang Shi and her PhD advisor, neurologist David Holtzman at Washington University were in for a surprise when they peeked at a set of brain slices from mice engineered to produce tau pathology.

After exposing the mice to single 20 - minute tDCS sessions, the researchers saw signs of improved memory and brain plasticity (the ability to form new connections between neurons when learning new information), which lasted at least a week.

So say Matthew Fuxjager and colleagues at the University of Wisconsin in Madison, who investigated the effect on the mouse brain of winning a fight home or away.

At 60 days post-weaning — the equivalent of mouse adulthood — the LPS mice could walk well, but were still hyperactive, suggesting the motor problems had resolved, possibly through some type of rewiring of the brain, but the behavioral problems had not.

Stephen Ferguson, PhD, a scientist at Western's Robarts Research Institute, and Fabiola Ribeiro, PhD, of the Universidade Federal de Minas Gerais in Brazil found a definite improvement in motor behaviors in a HD mouse model when one of the major neurotransmitters in the brain, called Metabotropic Glutamate Receptor 5 (mGluR5) was deleted.

Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have mobilized advanced imaging and computational methods to comprehensively map — «count» — the total populations of specific types of cells throughout the mouse brain.

Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.

At a neuroscience meeting, two teams of researchers will report implanting human brain organoids into the brains of lab rats and mice, raising the prospect that the organized, functional human tissue could develop further within a rodent.

Hongkui Zeng and colleagues at the Allen Institute for Brain Science in Seattle, Washington, injected the brains of 469 mice with a virus that introduced a fluorescent protein into the neural network.

The HSP70 - boosted mice were much better than the others at finding their way around mazes, and post-mortems showed their brains to be free of the characteristic beta - amyloid plaques that clog the brains of people with Alzheimer's.

One study published this year in Neurobiology of Aging, from researchers at the University of Southern California, examined brain changes in mice exposed to particulate air pollution at levels commonly found near freeways.

It seems that a build - up of the chemical in the brain is a hallmark of the ageing process, in mice at least.

Ronald Kahn and his colleagues at Harvard Medical School in Boston compared gene expression in brain samples from mice with type 1 or type 2 diabetes against those of healthy mice.

In looking at how cannabidiol affects brain neurons in the Dravet syndrome mouse model, the researchers observed that it rebalances the ratio of excitation to inhibition in the hippocampus.

At 10 weeks, the mice recovered, probably because the brain can heal itself, says study coauthor Brian Popko, a neurologist at the University of ChicagAt 10 weeks, the mice recovered, probably because the brain can heal itself, says study coauthor Brian Popko, a neurologist at the University of Chicagat the University of Chicago.

Then they prepared mouse brain slices from a group of neurons in the dopamine production center, at 24 hours and every day thereafter.

Using the supercomputers at Almaden and Lawrence Livermore National Laboratory, the group simulated networks that crudely approximated the brains of mice, rats, cats and humans.

He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.

Cory Blaiss, then at the University of Texas Southwestern Medical Center, and her colleagues genetically engineered mice such that the researchers could selectively turn neurogenesis on or off in a brain region called the hippocampus, a ribbon of tissue located under the neocortex that is important for learning and memory.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells.

Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed at sufficient levels in the early mouse brain to control gene regulation and allow development of healthy neuronal networks and behavioral characteristics.

Now scientists at the Massachusetts Institute of Technology (MIT) have taken a first step toward designing such a treatment: They have identified a protein that stimulates regrowth of severed eye - brain connections in mice, according to a report in tomorrow's issue of Nature.

«In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine.

Zhang did the research at Stanford Sleep Center, where he could record brain waves of snoozing mice.

Scientists at the Allen Institute for Brain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor - thin slices of mouse brain tiBrain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor - thin slices of mouse brain tibrain tissue.

In Nature Medicine today, Wyss - Coray's lab at Stanford and Saul Villeda and co-workers at the University of California, San Francisco, report that parabiosis can rejuvenate another part of the mouse brain, the hippocampus, where memories are made and stored.

Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their own insides.

In a paper published in the journal Neuron, researchers at Beth Israel Deaconess Medical Center (BIDMC) identified specific neural circuitry responsible for rousing the brain of mice in simulated apnea conditions.

Now, researchers at Washington University School of Medicine in St. Louis have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein amyloid beta.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

Five years ago, researchers at the Perelman School of Medicine, University of Pennsylvania, showed that the UPR is an adaptive response to stress induced by sleep deprivation and is impaired in the brains of old mice.

Researchers at Osaka University found that B immune cells reside in the brains of developing mice, and play a key role in the myelination of neurons by oligodendrocytes.

«In essence, the mice learned to repeat the same pattern of brain activity that had been evoked previously by hearing those musical notes,» said Vivek Athalye, a doctoral candidate at Champalimaud and the paper's co-first author.

When Gillian Bates at Guy's Hospital, London and Stephen Davies at University College in London and their colleagues examined the brains of transgenic mice endowed with a DNA encoding 150 of these glutamine repeats, they found that the protein started out, at birth, in the cytoplasm of the animals» brain cells and then gradually migrated to cell nuclei and clumped there.

Eric Nestler, a neuroscientist at Mount Sinai School of Medicine in New York City, wondered what the brains of these depressed mice looked like.

Using living mice, Sebastian Jessberger, a neuroscientist at the University of Zurich, and colleagues removed the outer layers of brain tissue that obscure the hippocampus.

These findings were confirmed by two - photon imaging of neurons in the brains of living mice by the lab of collaborator Yi Zuo, PhD, a neuroscientist at UC Santa Cruz, as well as electrophysiological recordings from neurons in brain slices by the lab of collaborator Vikaas Sohal, MD, PhD, an associate professor of psychiatry at UCSF.

The inspiration to use magnets to control brain activity in mice first struck materials scientist Polina Anikeeva while working in the lab of neuroscientist - engineer Karl Deisseroth at Stanford University in Palo Alto, California.

To understand how DIXDC1 mutations put normal brain function at risk, Cheyette's team turned to mutant mice that lacked a functioning copy of the gene.