Sentences with phrase «brains of mice engineered»

The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.

Not exact matches

So Yang Shi and her PhD advisor, neurologist David Holtzman at Washington University were in for a surprise when they peeked at a set of brain slices from mice engineered to produce tau pathology.

A mouse engineered to have Alzheimer's disease and a gradual reduction in levels of the brain enzyme BACE1 stopped forming plaques (arrows in the first panel) as it aged.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

Some of these mice were also engineered so that levels of the BACE1 enzyme, which is mostly found in the brain, gradually tapered off over time.

Half the mice were also engineered to make extra supplies of heat - shock protein (HSP) 70 in their brains.

Cory Blaiss, then at the University of Texas Southwestern Medical Center, and her colleagues genetically engineered mice such that the researchers could selectively turn neurogenesis on or off in a brain region called the hippocampus, a ribbon of tissue located under the neocortex that is important for learning and memory.

Click clock These days, new kinds of experiments using everything from computer simulations to brain scans to genetically engineered mice are helping unlock the nature of mental time.

«In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine.

Lichtman's genetically engineered mice, with neurons that would express different colors, began to bear fruit — or rather, to yield spectacular images of brains lit up like Christmas trees.

The UAB research team, led by J. David Sweatt, Ph.D., chair of the Department of Neurobiology and director of the Evelyn F. McKnight Brain Institute, removed H2A.Z in mouse models by means of a genetically engineered virus so that the subunit exchange could not take place.

They reached this conclusion during studies of mice engineered to build up protein fragments in their brains known to cause the disease.

The inspiration to use magnets to control brain activity in mice first struck materials scientist Polina Anikeeva while working in the lab of neuroscientist - engineer Karl Deisseroth at Stanford University in Palo Alto, California.

They got similar results when they engineered mice to lack another immune molecule, suggesting that B2M is part of a pathway that affects the brain.

To confirm the links, the group harnessed cutting edge techniques in genetic engineering and viral gene delivery to switch on neurons in the front of healthy mouse brains.

Researchers engineered seven versions of the Cambodian virus, each with one of the epidemic strains» mutations, and injected the viruses into fetal mouse brains.

To get to the bottom of this question, researchers in the Perelman School of Medicine at the University of Pennsylvania engineered mice in which the damage caused by a mutant human TDP - 43 protein could be reversed by one type of brain immune cell.

She and Dingledine were able to dissect COX - 2â $ ™ s effects because they engineered mice to have a deletion of the COX - 2 gene, but only in some parts of the brain.

In addition to developing the new genetically engineered mouse model for the form of cancer called glioblastoma multiforme, the researchers made a key discovery about brain tumor biology via the mice.

GIND investigator Li Gan, PhD, and her collaborators studied the development of neurons born in the hippocampus of adult mice genetically engineered to produce high levels of human Aβ in the brain.

The team used genetically engineered mice to study the effects of different human apoE variants on the maturation of neural stem cells or progenitor cells, from which new neurons develop in the adult brain.

Mice genetically engineered to lack PirB, or treated with an infusion of soluble PirB directly into the brain, also showed an increase in synaptic density and signalling in the visual cortex.

The devices include ultra-miniaturized light - emitting diodes, or LEDs, which allowed the researchers to stimulate the mice's brain cells, some of which had been genetically engineered to respond to light.

In one study conducted at the New York School of Medicine, researchers were able to observe synapse formation in the brains of genetically engineered mice.

Neuron expressing a fluorescent protein engineered by the Looger Lab was reconstructed from immunogold labeled serial sections of the mouse brain.

LaFerla, Mathew Blurton - Jones and Tritia Yamasaki performed their experiments using a new type of genetically engineered mouse that develops brain lesions in areas designated by the scientists.

Humans with Alzheimer's disease and mice genetically engineered to simulate the disease have abnormally low levels of an enzyme called EphB2 in memory centers of the brain.