First, they determined how repair proteins failed to recognize and act on chromosome
breaks during cell division.
Not exact matches
For proteins in the cytosol, the liquid inside the
cell, these random molecular processes include differences in the
break - down of proteins, or random partitioning into the two
cells that form
during cell division.
The scientists involved with this study were able to demonstrate that translocations can occur within hours of DNA
breaks and that their formation is independent of when the
breaks happen
during the
cell division cycle.
The de-repressed satellite RNAs induced damage to the chromosomes by fusing them inappropriately and
breaking them in what is called genomic instability, a catastrophic event for the
cell during cell division, which can lead to cancer.
During cell division, the DNA is doubled, which requires the histones — as the current picture suggests — to
break apart.