Not exact matches
The research team found that the experimental
group had an imbalance of cell populations in
breast tissue: too many luminal and too few basal.
To further identify the role of TAZ, the research team studied
breast tissue at different stages of development using two
groups of mice: a control
group with the TAZ gene and an experimental
group of knock - out mice with the TAZ gene deleted.
Looking forward, the
group is co-registering their imaging technique to gross histopathology of freshly excised
breast tissue specimens, and creating a database to correlate their imaging technique to
breast tissue pathological diagnoses.
A
group led by Eleanor Rogan, a cancer researcher at the University of Nebraska Medical Center in Lincoln, took samples of healthy
breast tissue from women with and without cancer and measured the amounts of estrogen derivatives.
And in a
group of women with an average age of 46,
breast tissue seemed three years older than real age (Genome Biology, doi.org/pcx).
Inclusion Criteria: • Availability of tumor
tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest
Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology
Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or
breast - feeding patients • Tumor type specific exclusion criteria
The winning ratio across all three
groups: 45:55, as in 45 % of
breast tissue falls above the nipple line and 55 % below.
It is actually a
group of hormones, called the estrogens, that are responsible for the development of female secondary sex characteristics: the development of
breast tissue and the proliferation of the uterine lining.