Sentences with phrase «breast tumor metastasis»

She anticipates that her research will lead to a better understanding the role of CCR7 (+) breast tumor metastasis to the lymph nodes, and how oncologists treat these tumors.

Not exact matches

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

They showed that the iKnife could distinguish normal and tumor tissues from different organs, such as breast, liver, and brain, and could even identify the origin of a tumor that was a metastasis, a secondary growth seeded by a primary tumor elsewhere in the body.

«We determined that it was specifically fructose, in table sugar and high - fructose corn syrup, ubiquitous within our food system, which was responsible for facilitating lung metastasis and 12 - HETE production in breast tumors.»

The team also found that these genes had different functions in promoting metastasis: One group encouraged growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.

The study team believes that the mechanism by which dietary sucrose or fructose affects breast tumor growth and metastasis, especially through the 12 - LOX pathways, warrants further investigation.

Houston Methodist researchers led by Dario Marchetti, PhD, have developed a blood test that can identify circulating tumor cells to predict breast cancer patients at risk for developing brain metastasis.

Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).

To further validate the clinical significance of miR - 7 and KLF4 in brain metastasis of breast cancer, we microdissected tumor tissues from both primary and brain metastatic lesions followed by conducting TaqMan qRT - PCR.

On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.

Abstract 466: Systemic early immune priming via tumor - secreted cytokines facilitates breast cancer metastasis in syngeneic mouse model

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.

May 12, 2016 Stopping cancer in its tracks Researchers from the University of Chicago have shown that inhibiting autophagy, a self - devouring process used by cells to degrade large intra-cellular cargo, effectively blocks tumor cell migration and breast cancer metastasis in tumor models.

Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model.

A CXCR4 antagonist CTCE - 9908 inhibits primary tumor growth and metastasis of breast cancer.

Oral delivery of PND - 1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

More recently, he has focused on triple - negative breast cancer, the role of micro-RNAs in cancer growth and metastasis, tumor heterogeneity and novel approaches to targeting therapy - resistant breast cancers.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

Review BRCA 1/2 Tumors and Gene Expression Therapy for Breast Cancer Development and Metastasis Anup P. Challa, Chikezie O. Madu, Yi Lu Oncomedicine 2017; 2: 132 - 137.

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To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).

These findings reveal a function for ABL kinases in the regulation of breast cancer bone metastasis and tumor - induced osteolysis in vivo.

Here, we uncovered a role for the ABL kinases in promoting breast cancer bone metastasis through the regulation of distinct pathways required for tumor colonization and survival in the bone microenvironment.

Similar to IL - 6 and MMP1, TNC is abundant in some breast tumors and promotes metastasis in mouse models (49).

We found that allosteric inhibition of the ABL kinases effectively impaired breast cancer bone metastasis and blocked tumor - induced osteolysis in mouse models.

These data suggest that ABL kinases promote breast cancer metastasis to bone in part by increasing tumor cell survival within the bone microenvironment.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

Importantly, NSCs can target breast cancer metastasis in the brain [9] and can penetrate deep and hypoxic regions of solid tumors [7].

Haihui Lu, Ph.D., a CRI fellow at the Whitehead Institute for Biomedical Research, has identified a surface marker that distinguishes a population of breast cancer cells that are more prone to metastasis and demonstrate higher levels of «stemness,» the ability to seed other tumors.

We report that ABL kinases promoted metastasis of breast cancer cells to bone by regulating the crosstalk between tumor cells and the bone microenvironment.

It is these same lymph vessels that carry tumor cells from breast tumors to the lungs or to other organs in a process called metastasis.