Sentences with phrase «breast tumors types»

Not exact matches

A radiologist will then check the images of your breast tissue to see if it's most likely a fibroadenoma or another type of breast tumor.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

«Low - dose chemotherapy regimens could prevent tumor recurrence in types of breast cancer, pancreatic cancer.»

The Wnt pathway is known to be inappropriately activated in many major tumor types, including colon, breast, liver, lung and pancreatic cancers, and is critical for the function of CSCs.

Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.

The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.

Triple - negative tumors are also more likely to spread and recur than other types of breast cancers.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

When breast cancer is diagnosed, the drug regimen that the patient receives is based primarily on the results of a biopsy that is used to identify the type of tumor she has.

Although breast cancer was the initial focus and featured in the study published online today, the team has also conducted experiments with other types of solid tumors, with similar results.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

They also showed that drugs against a type of breast tumor called HER2 positive breast cancer — such as the dual ERBB2 / EGFR inhibitor lapatinib — potentially could benefit more patients than currently receive them, if analysis of the tumor proteins is taken into consideration.

The screening revealed coibamide A to be capable of killing many types of cancer cells, but Ishmael decided to focus subsequent studies on two types in particular — brain tumors, or glioblastomas, and a breast cancer subtype known as triple negative breast cancer.

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

Since SFRP2 is expressed in many cancers — including breast, colon, pancreas, ovarian and kidney tumors — the technique could potentially be useful on a broad range of cancer types.

However, when we controlled for tumor characteristics and types of breast surgery, there was still a significant difference,» says Black.

The researchers» next steps will involve expansion of the biomarkers identified in this study to other cancer types, especially breast cancer, due to the hormonal input that is a common factor in gynecologic tumors.

Those include endometriosis and breast cancer — most types of breast cancer are sensitive to estrogen, meaning that estrogen helps tumors grow.

Different types of tumors show a preference for specific organs and tissues; circulating breast cancer cells, for example, are likely to take root in bones, lungs, and the brain.

«We also need to integrate PIK3CA mutation analysis of breast tumors into routine practice so that we can ensure women receive the most appropriate neoadjuvant therapy for their tumor type.»

«Agents that block the proteins — CDK4 / 6 inhibitors — have received Food and Drug administration approval for some patients with metastatic breast cancer, but they've also shown promise against others types of tumors in clinical trials.

In addition, the study, led by investigators in The Cancer Genome Atlas (TCGA) Research Network, revealed four novel tumor subtypes, while also identifying genomic similarities between endometrial and other cancer types, including breast, ovarian, and colorectal cancers.

BRCA1 - and BRCA2 - deficient breast tumors display impaired homologous recombination repair (HRR), and defective HRR can increase the sensitivity of those tumors to various types of therapy, including PARP inhibitors.

«Finding genomic similarities among types of breast, ovarian, endometrial and colorectal tumors once again reveals that cancer, although very complex, may have themes extending beyond tissue type that can be exploited for therapeutic benefit,» said Eric D. Green, M.D., Ph.D., NHGRI director.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

A Mayo Clinic research team has developed a new type of cancer - fighting nanoparticle aimed at shrinking breast cancer tumors, while also preventing recurrence of the disease.

The study evaluated the efficacy and safety of cabozantinib compared to placebo in 9 different solid tumor types including breast, lung, ovarian, and prostate.

The aggressive basal - type breast cancers often metastasize, seeding new tumors in distant parts of the body.

This clinically defined tumor type overlaps substantially but not completely with «basal - like» breast cancer, a classification based upon gene expression signature.

Triple - negative breast cancer (TNBC), a tumor type defined by its lack of estrogen receptor, progesterone receptor, and Her2 (ERBB2) amplification, accounts for 16 % of breast cancers.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion critumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criTumor type specific exclusion criteria

-- discovery awarded international science prize Researcher Allison Cleary has, for the first time, demonstrated that different types of tumor cells cooperate in the development and growth of breast cancer.

Researcher Allison Cleary has, for the first time, demonstrated that different types of tumor cells cooperate in the development and growth of breast cancer.

Inflammatory breast cancer, or IBC, is an uncommon type of breast cancer in which there is usually no single lump or tumor.

Treated tumor types include hepatocellular carcinoma, cholangiocarcinoma, neuroendocrine tumor, colorectal cancer, breast cancer, melanoma, and soft tissue sarcoma.

The challenge is that these mutations are «personal» to the tumor and patient; i.e., not all types of breast cancer carry the same set of mutations, and as a result, different patients have a different, personal set of mutations.

By exploiting these differences, scientists have developed therapies that target specific tumor types, and these targeted therapies have proven useful against most breast cancers.

«We found a strong reduction in the risk of estrogen - receptor - negative [ER --RSB- breast cancer in particular, which is exciting because that type of tumor, while rarer than estrogen - receptor - positive [ER +] tumors, tends to be aggressive.»

But when her doctor told her that the type of tumor she had — invasive lobular carcinoma — slightly increased her risk of developing cancer in the unaffected breast, she decided to have a double mastectomy and sacrifice her ability to breast - feed.

In many cases, physicians will find that the patient also has a ductal carcinoma in situ tumor, but there are some patients that are also diagnosed with an invasive type of breast cancer when a physician find that they have developed Paget disease.

By performing tumor sample testing we can determine what type of breast cancer it is, and what subtypes of breast cancer are relevant to the case.

It is considered that Soya isoflavones decrease hot flushes, osteoporosis related problems and hormonal depending types of tumors (i.e. breast cancer).

Protect against breast cancer: Women who are genetically susceptible to breast cancer may benefit from higher vitamin D levels, as it interferes with the genetic pathway responsible for these types of tumors.

The doctor reading your mammogram will be looking for different types of breast changes, such as small white spots called calcifications, lumps or tumors called masses, and other suspicious areas that could be signs of cancer.

May 16, 2018 • An aggressive type of breast cancer — a HER2 - positive tumor — often shrinks with Herceptin treatment, but side effects can be tough.

These are tumor - suppressor genes impilicated in some types of breast and ovarian cancers.

Mammary (breast) tumors are probably the most common type of cancer seen especially in rats and mice.

Canine breast cancer - this type of cancer accounts for 50 % of tumors found in bitches.