Sentences with phrase «breast tumour cells»

Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012) Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells Cell Oncol (Dordr), 35 (3), 217 - 27 PubMed 22700320

Not exact matches

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

High levels of the protein were also found in cultures of metastatic cells from tumours of the colon, breast, head and neck.

Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.

Around 15 per cent of women with breast cancer have this form of the disease, in which tumour cells lack the three receptors that most drugs target.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Around 70 % of all cases of breast cancer are oestrogen - receptor positive, meaning that the cancer cells have a particular protein (known as a receptor) that responds to the female sex hormone oestrogen, enabling the tumour to grow.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

In addition, they showed for the first time that these genes are often the same as those that are altered in breast tumours - when a tumour develops, the DNA within the cancer cells themselves mutates.

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

«Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMaster.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

The team found that most of the genetic changes in the original breast tumour were also present in the metastatic tumours, showing that the cancer cells spread late in disease development.

In collaboration with Dr Gabriele Bonatz from the Augusta clinics in Bochum (Brustzentrum), Hatt's team confirmed the existence of TRPV1 in tumour cells in nine different samples from patients suffering from breast cancer.

When cancer cells from eg breast or lung tumours invade the bones through metastasis, the bone tissue is degraded.

Using a CRISPR - dCas9 epigenetic editing tool, the researchers methylated different genes in healthy breast cells and found that those changes were sufficient to cause the cells to undergo «hyperproliferation» — abnormally rapid cell division which is an early stage of tumour initiation.

Dr Claus Jorgensen, who led the research at The Institute of Cancer Research, London, and at Cancer Research UK's Manchester Institute at the University of Manchester, said: «The next step is to figure out how to keep this receptor switched on, so that the tumour cells can't leave the blood vessels — stopping breast cancer spreading and making the disease easier to treat successfully.»

A new biomarker could help identify abnormal breast cells that will develop into tumours, according to research published in Clinical Cncer Research.

Tamoxifen prevents oestrogen from stimulating growth of breast cancer cells but some tumours can eventually develop resistance to the treatment, making the drug ineffective.

Combining a cancer therapy with a second drug therapy that helps suppress tumour blood vessels found in cancer cells can help to significantly reduce the spread of breast cancer tumours while also causing cancer cell death.

T - cells (red, yellow, and blue) attack a tumour in a mouse model of breast cancer following treatment with radiation and a PD - L1 immune checkpoint inhibitor, as seen by transparent tumour tomography.

Her expertise includes isolation of stem cells from multiple organs as well as from solid tumours and fluid aspirates associated with breast and ovarian tumours.

Anti-angiogenic agents increase breast cacner stem cells via the generation of tumour hypoxia

Research has discovered that a compound in parsley could prevent the growth of specific breast cancer tumour cells.

The Journal of Agricultural and Food Chemistry had on its December 2006 issue a report that found the ability of red raspberries to repress the human oral and breast, as well as colon and prostate tumour cell lines growths when they were tested in test tubes.

Malignant lymphomas (lymph node tumours), skin cancer (mast cell tumours), bone cancer, and breast cancer (mammary gland tumours) are very common in elderly furkids.

Most cases of breast cancer in dogs (approximately 76 percent) are adenocarcinomas, or tumours that develop in the dog's breast duct cell linings.