Sentences with phrase «broad populations of patients»
Poly (ADP - ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target...
https://www.jci.org/ Not exact matches
«While we are disappointed CheckMate - 026 did not meet its primary endpoint in this broad patient population, we remain committed to improving patient outcomes through our comprehensive development program, including the ongoing Phase III CheckMate - 227 study exploring the potential of the combination of Opdivo plus [our other cancer immunotherapy] Yervoy for PD - L1 positive patients, and Opdivo plus Yervoy, or Opdivo plus chemotherapy in PD - L1 negative patients,» he added.
«Our technology will greatly increase the efficacy of neuromodulation and enable access to broader patient population.»
«Licensure is critical because it will ensure the quality, consistency and safety of the islet product; provide greater patient access to islet transplantation; and accelerate continued research that we hope would make this procedure suitable for a broader population of people with type 1 diabetes.»
In a related commentary, Paul B. Ginsburg, Ph.D., University of Southern California, Los Angeles, writes: «There is broad consensus among physicians, hospital and health insurance leaders, and policy makers to reform payment to health care providers so as to reduce the role of fee for service, which encourages high volume, and instead to use systems that reward better patient outcomes, such as bundled payments for a population or for an episode of care.»
«For the broad application of stem cell - derived pituitary cells in the future, cell replacement therapy may need to be customized to the specific needs of a given patient population,» Zimmer says.
Drug - resistant bacteria that usually attack only hospital patients may now have jumped into broader circulation in the general population, according to a study in tomorrow's Journal of the American Medical Association.
Niraparib significantly improved all endpoints across a broad patient population representing 70 % of all ovarian cancer patients.
Researchers leading the largest genomic tumor profiling effort of its kind say such studies are technically feasible in a broad population of adult and pediatric patients with many different types of cancer, and that some patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.
«We need to study a broader patient population to not only validate these findings but also determine other factors, such as inflammatory cytokines, that may contribute to the development of fatty liver in the IBD population.»
We leverage our cutting - edge platforms to produce product candidates and utilize distinct therapeutic approaches that, we believe, address the shortcomings of existing therapies and have the potential to treat a broad patient population either as individual therapies or in combination with other mechanisms of action.
In addition to her expert skill as a clinician, Dr. Frontera also has many research interests including identifying biomarkers and predictors of early brain injury and vasospasm / delayed cerebral ischemia after subarachnoid hemorrhage and their impact on outcome; determining the efficacy of therapeutic strategies and developing guidelines for the management of patients with intracranial hemorrhage; evaluating the cost, length of stay, quality of life, functional and cognitive outcomes in a broader population of intracranial hemorrhage patients; developing guidelines for the integration of palliative care into the intensive care unit setting; and evaluating the relationship of Zika virus infection, Guillain - Barre, and other neurologic disorders.
Trotti, Maness and colleagues didn't set out to dive into ME / CFS — they explicitly label this paper a pilot study, and the results say more about the «hypersomnolent» group of patients they have been seeing for the last several years, rather than the broader ME / CFS population.
«This analysis of a large population of patients across a broad scope of tumor types suggests that avelumab was associated with an incidence of immune - related adverse events that is consistent with that of other immune checkpoint inhibitors.»
My research interests focus on understanding mechanisms of natural control of HIV - 1 infection in «elite controllers», and on developing clinical strategies that may lead to a long - term drug - free remission of HIV - 1 infection in a broader patient population.
Our two primary product candidates, CMB305 and G100, utilize distinct immuno - oncology approaches that, we believe, address the shortcomings of existing therapies and have the potential to treat a broad patient population either as individual therapies or in combination with other mechanisms of action.
In a recent study by Helmsley grantee the Broad Institute of Harvard and MIT, researchers identified how the intestinal microbial population of Crohn's disease patients differs from that of individuals free of inflammatory bowel disease.
This inpatient multidisciplinary collaborative practice model should be evaluated in broader drug categories and patient populations to ensure reproducibility of these findings.
Transportation and accommodation coverage for rural and remote patients to allow for treatment in a metropolitan centre, and urgent review of the prosthesis listing process are also singled out in the AHHA submission, along with improved cultural liaison to boost coverage of Aboriginal and Torres Strait Islander people (20 % vs 57 % in the broader population).