Another research goal is a safe and more
broadly effective vaccine, which remains one of the most difficult challenges, according to Drs. Fauci and Eisinger.
Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are
effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with
broadly neutralising antibodies and / or T - cell
vaccines, to achieve HIV eradication.