Using sophisticated imaging technology, they were then able to watch as
the broken ends of the chromosomes were reattached correctly or incorrectly inside the cells.
Not exact matches
In Cooper's lab, Godinho Ferreira worked to understand why telomeres function differently than deleterious
chromosome ends generated by the abnormal
breaking of chromosomes.
James Christiansen, professor
of biology at Drake University in DesMoines, is studying how telomeres, the simple, non-genetic DNAsequences that sheathe the
ends of chromosomes, function in reptiles.Each time a healthy human cell divides, it loses a little bit
of thetelomere, until the strands are too short to protect the
chromosomes.At that point the DNA in a cell begins to
break down, which triggerssenescence and death.
In this situation, the movement
of broken ends can cause pieces from different
chromosomes to stick together, forming monster
chromosomes that kill the cell.
However, in rare cases, the
ends of the
chromosome become either damaged or
broken, and fuse together forming a circle, or ring.
They protect
chromosome ends from being mistaken for
broken pieces
of DNA that would otherwise be fixed by cellular repair machinery.