With the three - year grant, Vanapalli and his collaborators Boyd Butler in the Department of Biological Sciences and Everardo Cobos at the Texas Tech University Health Sciences Center, will
build microfluidic devices that mimic blood flow to study how tumor cells move inside capillaries, how they squeeze through tight spaces, whether they are subject to fragmentation and how they become stuck.
Not exact matches
To study this barrier and determine why a lack of blood flow causes it to leak, the researchers
built a blood - vessel - on - a-chip model consisting of a channel lined with a layer of human endothelial cells surrounded by extracellular matrix within a
microfluidic device, which allowed them to easily simulate and control the flow of blood through a vessel and evaluate the cells» responses.
«Researchers
build liquid biopsy chip that detects metastatic cancer cells in blood: More effective than existing
microfluidic devices, the breakthrough technology.»
«Our technology will provide significantly higher forces and faster impact cycles than have previously been possible, and by
building these tools onto
microfluidic devices, we can leverage a host of other on - chip diagnostics and imaging tools and can collect the cells after testing for longer - term studies,» said Valentine.