Sentences with phrase «buildup of amyloid protein»

Not exact matches

The bulk of research scientists working on Alzheimer's have long believed that a buildup of amyloid «plaques» is central to the disease's development — and that therefore targeting this protein is the best chance for a cure.

For one, it would give them three specific biological markers to hone in on: The buildup of beta amyloid and tau proteins, which cause brain plaques associated with Alzheimer's, and brain nerve cell death.

According to the proposal, called the amyloid hypothesis, Alzheimer's disease, estimated to affect more than 5 million people in the United States alone, is caused by abnormal buildup of A-beta protein in the brain.

Recent research also has illuminated how the deadly cascade that leads to brain atrophy is set in motion: The buildup of amyloid plaques, working in tandem with certain gene mutations, sparks the formation of the renegade tau proteins.

Researchers have proposed that Alzheimer's disease is caused by the buildup of a sticky protein called beta - amyloid.

Like cardiovascular disease, Alzheimer's involves the buildup of plaque, in this case tangled beta - amyloid proteins in the brain.

It not only prevented the buildup of amyloid beta (Aß), a sticky protein linked to Alzheimer's, but it also does not appear to produce the dangerous side effects of earlier versions tested in humans.

«Activation of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director of Georgetown's Laboratory for Dementia and Parkinsonism, and scientific and clinical research director of the GUMC Translational Neurotherapeutics Program.

More than 40 illnesses known as amyloid diseases — Alzheimer's, Parkinson's and rheumatoid arthritis are a few — are linked to the buildup of proteins after they have transformed from their normally folded, biologically active forms to abnormally folded, grouped deposits called fibrils or plaques.

Spinal fluid analyses and positron emission tomography (PET) scans can detect a key warning sign — buildup of amyloid - beta protein in the brain.

Many neuroscientists believe that a buildup in the brain of a protein fragment called beta - amyloid causes Alzheimer's disease.

The disease is largely attributed to an abnormal buildup of proteins, which can form amyloid beta plaques and tangles in the brain that trigger inflammation and result in the loss of brain connections called synapses, the effect most strongly associated with cognitive decline.

The new therapy targets beta - secretase, an enzyme on neurons around which plaques (buildups of a protein called beta - amyloid) cluster in the brain.

The DNA change may inhibit the buildup of β amyloid, the protein fragment that accumulates in the hallmark plaques that form in the brains of Alzheimer's patients.

While the buildup of sticky proteins called amyloid plaques in the brain has been repeatedly linked to Alzheimer's disease, the role of blood in the formation of the condition has been less clear.