Sentences with phrase «by abl»

Decreased metastasis by ABL - deficient breast cancer cells was accompanied by a significant reduction in the extent of hindlimb osteolytic lesions, as determined by x-ray and micro — computed tomography (μCT) imaging (Fig. 2, I and J).

Not exact matches

A skilled mortgage broker can accommodate a range of client needs by cross-selling products like factoring or ABL, unsecured lines of credit, purchase - order financing, mezzanine loans, merchant - cash advances, or short - term working - capital loans.

The first out ABL lenders sought full payment for contingent indemnification claims and certain expenses as a condition to a credit bid by Standard General, its counterparty under the 2013 credit agreement AAL.

To support acquisition by Fred's of 865 Rite Aid stores, Bank of America, Merrill Lynch and Regions Capital have provided $ 1.05 billion of committed ABL financing.

First, the first out ABL lenders under the 2013 credit agreement objected by claiming that under their applicable AAL, Standard General as last out lender under that facility was precluded from submitting a credit bid if any obligations to the first out ABL lenders remained outstanding.

In addition, every issue of the ABF Journal includes timely cover stories and articles authored by industry specialists, plus our regular features encompassing briefs of the top industry related news stories, exclusive interviews with industry leaders, notable ABL transaction summaries and commentary from our team of contributing writers on turnaround management, legal topics and case studies and other relevant insights from ABL industry practitioners.

About 1,500 residents of Adabraka and its environs in Accra, have benefited from a free health screening exercise organized by Accra Brewery Limited (ABL) in partnership with the Graphic Communications Group Limited (GCGL).

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

In a mouse model in which they simulated the development of CML by adding Bcr - Abl to the bone marrow, a shortage of Gab2 led to a clear weakening or even a lack of symptoms.

Developed by the US Department of Defense's Missile Defense Agency (MDA), the ABL aims to focus a beam of laser energy in the megawatt range for several seconds onto a missile at a...

Therefore, a team led by Vladimir Tesar, MD, PhD (Charles University and General University Hospital, in the Czech Republic) tested the potential of an investigational drug called bosutinib that inhibits a particular tyrosine kinase called Src / Bcr - Abl.

Although the Airborne Laser (ABL) was fired from a stationary plane at a target on the ground just a few metres away, the test marked a milestone for the weapon, developed by aerospace firms Boeing, Lockheed Martin and Northrop Grumman.

By using these reagents and v - abl - specific antisera, it was demonstrated that the P210 in CML cells is indeed the protein product of the 8.5 - kilobase transcript.

By analogy to the gag / abl fusion protein of Abelson murine leukemia virus, the replacement of amino terminal c - abl sequences by bcr sequences in P210 may create a transforming protein involved in CMBy analogy to the gag / abl fusion protein of Abelson murine leukemia virus, the replacement of amino terminal c - abl sequences by bcr sequences in P210 may create a transforming protein involved in CMby bcr sequences in P210 may create a transforming protein involved in CML.

CML cells have two novel products: an 8.5 - kilobase RNA transcript containing both abl and bcr and a 210 - kilodalton phosphoprotein (P210) recognized by v - abl - specific antisera.

Abrogation of the cell death response to oxidative stress by the c - Abl tyrosine kinase inhibitor STI571.

[citation needed] In 2000 Dr. John Kuriyan determined the mechanism by which STI - 571 inhibits the Abl kinase domain.

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

AXL mediates resistance to TRAIL - induced cell death in esophageal adenocarcinoma (55); it remains to be determined whether ABL - mediated protection from TRAIL - induced apoptosis in breast cancer cells is mediated by AXL or other targets.

To evaluate whether loss of ABL kinases affected TAZ activity, we performed chromatin immunoprecipitation (ChIP) analysis using primers for TAZ targets identified by ChIP sequencing analysis (42).

However, these reciprocal decreases were much lower than those induced by knockdown of the ABL kinases (Fig. 7).

STAT5 is also activated by the oncogenic breakpoint cluster region (BCR)-- ABL tyrosine kinase and contributes to the transformation of leukemia cells (45).

TRAIL - enhanced apoptosis as measured by cleavage of caspase - 3 (Fig. 4I), and knockdown of ABL kinases increased the sensitivity of 1833 breast cancer cells to the proapoptotic effects of TRAIL (Fig. 4, G to I).

To further validate that the decreased metastasis induced by double knockdown of ABL1 and ABL2 was not due to off target effects of the lentivirus - encoded shRNAs, we used a second set of ABL shRNAs (shAA # 2) and carried out rescue experiments by expressing mouse Abl1 and Abl2 constructs (mAbl1 / Abl2) that are resistant to shRNAs against human ABL1 and ABL2.

Double knockdown of ABL1 and ABL2 was required to decrease the phosphorylation of CrkL by more than 90 %, which indicates inactivation of the endogenous ABL kinases (Fig. 2K).

Thus, we evaluated whether addition of IL - 6 could in part rescue defective osteoclastogenesis induced by conditioned medium from breast cancer cells depleted of the ABL kinases.

Expression of a constitutively active STAT5A mutant (STAT5A *) reversed the reduction in MMP1, IL - 6, and TNC abundance induced by depletion of both ABL kinases in breast cancer cells (Fig. 7, E and F, and fig.

These findings suggest that ABL kinases regulate osteoclast maturation indirectly, possibly by modulating osteoblast function.

These findings suggest that ABL kinases promote tumor - induced osteoclast activation in part by increasing OPG abundance in osteoblasts.

To identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.

Depletion of ABL kinases impairs tumor - induced osteoclast activation in part by decreasing IL - 6 secretion.

Depletion of ABL kinases in breast cancer cells decreased IL - 6 concentrations and was accompanied by increased OPG expression in osteoblasts.

These data suggest that ABL kinases promote breast cancer metastasis to bone in part by increasing tumor cell survival within the bone microenvironment.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

This rules out the possibility that resistance to inhibitors results from a steric hindrance as proposed for the Thr315 mutations of ABL.13, 33 However, the crystal structures of JAK1 and JAK2 also show that Phe958 or Tyr931, respectively, are in direct contact with the CMP6 inhibitor.21 The replacement of Phe958 by Val / Cys / Ser / Leu abolishes this interaction and should decrease the affinity for this compound (Figure 2C).

We have demonstrated the importance of c - ABL in driving inflammation injury in our acute DSS model in the publication by Gordon et al. (2013).

Because of robust off - target effects of most RIPK2 inhibitors, we carried out molecular modeling (docking) and cheminformatics analyses by carefully analyzing the only known crystal structure of RIPK2 in association with the c - ABL kinase inhibitor ponatinib (https://www.rcsb.org/pdb/explore/macroMoleculeData.do?structureId=4C8B).

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

We report that ABL kinases promoted metastasis of breast cancer cells to bone by regulating the crosstalk between tumor cells and the bone microenvironment.

Periodontal status was assessed by Probing Pocket Depth (PD), Bleeding on Probing (BOP), and radiographic Alveolar Bone Loss (ABL), measured on intraoral periapical radiographs with a modified Schei ruler method.

Now available, you can find out more about the Abl Master Scheduler by going to their site, here.

«Throughout our collaboration, Abl's design team focused on the real - world challenges we face to ensure that its software reflects the workflows and practices utilized by school principals.

To support its pioneering efforts to simplify the master scheduling process, education technology startup Abl today announced $ 7.5 million in Series A funding, led by Rethink Education.