Sentences with phrase «by csc»

Dining Etiquette Seminar CSC SIFE continued the very popular Business and Dining Etiquette Seminar conducted by CSC instructor Vickie Culbertson and Coordinator of Employment Resources, Jan Hipple.Dining Etiquette Seminar CSC SIFE member Donna Lindsey took the lead in establishing CSC's first business ethics and dining seminar conducting by CSC instructor Vickie Culbertson and Jan Hipple, coordinator of employment resources.A resume building class conducted by Jan Hipple, employment coordinator for CSC, was followed by interview skills instruction from Travis Wilhite, store manager of the Galesburg Wal - Mart and CSC SIFE Business Advisory Board member.

Selects appropriate prior authorization forms, completes them as directed by the CSC pharmacist and submits to the applicable payer for review in a timely manner.

Also, every activity performed by CSC will be having some fixed service charge.

The Court commented that adverse action taken by the CSC based on absences due to disability or family responsibilities attracting CHRA protection could constitute discrimination.

More recently, internet sleuths discovered that websites «pokemonletsgopikachu.com» and «pokemonletsgoeevee.com» were registered by CSC Corporate Domains, Inc. — the same company that acts as a tech contact for the official pokemon-sunmoon.com website.

UPDATE: Website domains for pokemonletsgopikachu.com and http://pokemonletsgoeevee.com have been registered by CSC Corporate Domains, a company that registers trademarks for Nintendo.

You can also use a commercial UCC search engine such as the one offered by CSC Global.

In the first two years of CSC, teachers were asked to conduct class meetings for observation by CSC coaches and administration.

As a result, patients from Brazil, Portugal, and Spain have been helped by CSC's services.

Not exact matches

Crypto Stake Coin or CSC is a fully managed asset that is backed by a basket of POS coins, we are also hedged with a small amount of POW mining.

Feld is CSCS certified by the National Strength and Conditioning Association and holds a SCCC certification from the Collegiate Strength and Conditioning Coaches Association.

Amelia Hunter Baby Sleep Solutions by Amelia Hunter 0034-66-352-3110 Education: Certificate III in Nursing — Sydney Australia TEFL Certificate teaching English as a foreign language — Barcelona Spain Certified Sleep Sense Consultant — Sleep Sense Practicing as a CSC: since 2016

Most Distinguished Athletic Trainer of the Year presented by FastFingerprints Patricia Tripp, PhD, LAT, ATC, CSCS

In addition to Brunelle, who is the AT at Jamestown Community College, and Hart, who works as a per diem AT in the Rochester area, the NYSATA exhibit booth was manned by Jarett Rhoads, MSEd, ATC, CSCS, of Eastridge High School (East Irondequoit) and Phil Steckley, MS, ATC, CSCS of West Irondequoit High School.

The Administration proposes to restructure the current Climate and Land Use Change program, eliminating $ 11.1 million in climate research and development activities and reducing Interior's Climate Science Centers (CSCs) by $ 8.5 million, halving the number of regional CSCs from eight to four.

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2 - DG by tenfold in terms of potency.

The CSC team began by looking for mutations in the DNA of 100 people with liver cancer.

CSC is a nonprofit company owned by the Finnish Ministry of Education, the aim of which is to provide IT computational support to universities and research institutes.

The CSC team are the first to show that it does so by disrupting senescence.

We then confirmed the expression of miR - 7 and miR - 21 in CSCs of these cells by TaqMan qPCR and found that only miR - 7 was significantly downregulated in CSCs in both 231BoM and 231BrM, suggesting that miR - 7 may contribute to the metastatic ability of CSCs (Fig. 1B).

CSCs were prepared from 231BrM and CN34BrM cells that were infected with lentivirus carrying with or without miR -7-2, and they were transplanted into nude mice through intracardiac injection followed by monitoring metastatic tumor growth in the brain.

As shown in Fig. 4B, suppressive ability of miR - 7 on both transmigration through endothelial cells and Matrigel was significantly attenuated by ectopic expression of KLF4, suggesting that miR - 7 suppresses invasive ability of CSCs by blocking KLF4 expression.

This is also exemplified by the fact that CSCs from different organs have been isolated by using different markers (1, 19).

B, the expression of miR - 21 and miR - 7 were examined by TaqMan PCR in CSCs prepared from MB231, 231BoM, and 231BrM.

C, miR - 7 expressions in both parental cells and CSCs from different cell lines were measured by TaqMan PCR.

We then examined the metastatic ability of these cells by implanting various doses of CSCs into mice via intracardiac injection.

In breast cancer, CSCs or tumor - initiating cells were first identified by using a combination of cell surface markers, CD24 − / CD44 + / ESA (EpCAM) + (2).

We then measured the population of CSCs by FACS after 72 hours as well as their mammosphere - forming ability by counting the number of spheres after 10 days.

The results of our in vitro experiments strongly suggest that miR - 7 plays a role in metastatic CSCs by modulating the expression of KLF4.

We found that miR - 7 was significantly downregulated in metastatic CSCs and specifically blocked brain metastasis in our animal model by modulating the KLF4 expression.

Next, because KLF4 is involved in self - renewal of stem cell, we also examined the effect of both miR - 7 and KLF4 on proliferation of CSCs by MTS assay and found that miR - 7 was capable of blocking the growth of CSCs, whereas ectopic expression of KLF4 significantly mitigated this effect of miR - 7 (Fig. 4C).

Taken together, these results suggest that CSCs are essential for metastatic colonization and that CSCs induce stromal fibroblasts to secrete POSTN in the metastatic niche to support tumor cell outgrowth by augmenting the Wnt signaling pathway.

C, primary breast cancer cells isolated from patients with advanced cancer were directly infected with KLF4 or control lentivirus, and the CSC population (CD24 − CD44 + ESA +) was measured by FACS after culturing the cells for 72 hours in low - attachment plates.

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

The CSC theory suggests that such CSCs persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors [8 — 10].

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

These findings strongly suggest that we have succeeded in isolating a unique metastatic CSC population by exposing breast cancer cells to repetitive cycles of hypoxia and reoxygenation.

It was reported, for example, that CSC state could be maintained by overexpressing hypoxia - inducible transcription factor (HIF2α) in glioma cell lines [40].

The percentage of CSCs in the cycling hypoxia selected subpopulation was analyzed based on the CD44, CD24, ESA, and E-cadherin expression by three - color flow cytometry.

Other earlier work led by Christine Chaffer, a postdoctoral researcher in the Weinberg lab, demonstrated that cancer cells are able to spontaneously become CSCs.

The link between CSCs and metastasis has been suggested by several studies.

However, as demonstrated by a recent report from Stuelten and colleagues [13], the complexity of CSC markers continues to pose challenges for identifying and isolating the putative tumor stem cell populations by the cell - sorting approach.

By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].

Future studies need to clarify whether smaller subgroups of breast cancer, defined according to expression array criteria, will behave in ways similar to ER - α — positive or negative breast cancer but it is clear that the 2 major disease subgroups, defined by ER - α status, show contrasting hypoxic CSC responses.

CSC is funded by angels and furnished with a pool table, a gas fireplace, a chef's kitchen, and photos of Keirstead with Keanu Reeves, Ed Bradley, Warren Buffett, and Bill Gates.

No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a single significant gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.

CSC enrichment was achieved by collection of anoikis - resistant cells as we have previously shown this population to be highly enriched for mammosphere and tumor - initiating cells (25).

An important question is how the CSC fraction is altered by hypoxia.

The aims of this study, therefore, were to assess the effects of hypoxia on breast CSC in cell lines and primary samples and to elucidate the mechanism by which these changes take place.

There was a HIF - 1α — dependent CSC increase in ER - α — positive cancers following hypoxic exposure, which was blocked by inhibition of estrogen and Notch signaling.