Sentences with phrase «by jak»

The sculptural installation by JAK and the performance «Of Serra (to movement)»

The sculptural installation by JAK and the performance «Of Serra (to movement)» are on display in Gallery 1.

It's written by Jak Koke, the writer of the Shadowrun novels, so despite some generic JRPG dialogue the overall themes are actually rather interesting.»

Strikingly, diseases such as rheumatoid arthritis all feature inflammatory processes driven by JAK / STAT activity and the effectiveness of MTX in these inflammatory diseases may well be a consequence of its ability to dampen the JAK / STAT pathway.

Additionally, the 9BS Group has offered to build three solar - powered mechanised boreholes at locations to be identified by the JAK Foundation, at the estimated cost of GHc 240, 000.

A ceremony to raise money for the Endowment Fund, which was organised by JAK Foundation, was in line with the «80 for 80» campaign, which seeks to raise GH cents 80 million cedis ($ 15 million) to commemorate the upcoming 80th birthday of former President Kufuor on December 8.

Not exact matches

The donation, made by the company at a fundraising dinner held on Friday, is to support the JAK Foundation construct a leadership centre at the University of Ghana (UG) campus at Legon.

An Endowment Fund of The John A. Kufuor Foundation (JAK Foundation) has been launched in Accra in promoting the legacy of selfless leadership and commitment to national development by a former President of the Republic of Ghana, JAK Kufuor.

He said all the projected will be funded by the group, which has also donated GHc 260,000 in support of the fundraising efforts by the John Agyekum Kufuor (JAK) Foundation to build three mechanised boreholes at locations to be chosen by the Foundation

The study raises the possibility that drugs known as JAK inhibitors could be used to restore hair growth in multiple forms of hair loss such as that induced by male pattern baldness, and additional types that occur when hair follicles are trapped in a resting state.

Christiano and her colleagues serendipitously discovered the effect of JAK inhibitors on hair follicles when they were studying a type of hair loss known as alopecia areata, caused by an autoimmune attack on the hair follicles.

Two JAK inhibitors have been approved by the U.S. Food and Drug Administration.

Shannon entropy analysis of the NS5 polymerase mature protein revealed that a G374E mutation, in a region that contributes to interferon resistance in other flaviviruses by interfering with JAK - STAT signaling was present in both the Asian and American sequences from the 2007 - 2008 Venezuelan outbreak, but was absent in the sequences from the 2001 Venezuelan outbreak.

Follin - Arbelet V, Torgersen ML, Naderi EH, Misund K, Sundan A, Blomhoff HK Death of multiple myeloma cells induced by cAMP - signaling involves downregulation of Mcl - 1 via the JAK / STAT pathway Cancer Lett (in press) PubMed 23454584

This occurs by PTP1B dephosphorylating or removing phosphates from the JAK2 kinase, and preventing JAK to activation.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

These JAK1 mutations provide cells with tumorigenic potential by inducing constitutive activation of the JAK - STAT pathway, which supports their autonomous proliferation.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

By Western blot analysis, we first examined whether the Janus - activated kinase (JAK)- STAT pathway — activated ISGF3 complex was involved in IFNα - induced RIG - G up - regulation.

In comparison with the direct transcriptional response of IRF - 1 to IFNα, the RIG - G mRNA induction was entirely blocked by cycloheximide (Fig. 1B), indicating that the RIG - G was not a primary responsive gene in IFNα - induced JAK - STAT pathway.

IL7R is expressed in HCC but not in normal liver cells, and can activate JAK2 to increase cell growth.57 SOCS3 is a negative regulator of the JAK / STAT signalling pathway, and can inhibit JAK2 itself.58 Therefore, inhibition of JAK2 by SOCS3 could result in decreased proliferation.

If you play through each character's campaign, towards the end you will be gifted with a cut scene in which your character will stumble upon their rival (another character in the game), and it results in some rather humorous and entertaining viewing; Jak and Ratchet's confrontation is helped by the banter between Daxter and Clank, and Sackboy and Big Daddy's standoff is fuelled by some surprisingly well executed charm.

Jak (Jonathan Tucker, from the Texas Chainsaw Massacre remake) and his buddy Boxx (Ryan McDonald) do what they can to get by.

the Sports Quiz Call of Duty: Finest Hour Capcom Classics Collection Capcom Classics Collection Volume 2 Cars Castlevania Curse of Darkness Champions: Return to Arms Cold Fear Colosseum road to freedom Commandos Strike Force Conflict Global Storm Constantine The Chronicles of Narnia - The Lion, the Witch & the Wardrobe Crash of the Titans Crash N Burn Crazy Frog Darkwatch Death by Degrees Devil May Cry 3 Devil Kings Destroy all Humans Dragon Quest VIII: The Journey of the Cursed King Dragonball Z: Budokai Tenkaichi Dragonball Z: Budokai 4 Dragonball Z Budokai Tenkaichi 2 Drakangard Driver: Parallel Lines Dynasty Warriors 5 Eragon Everbody's Golf Everbody's Tennis Eyetoy: Antigrav Eyetoy: Kinetic Eyetoy: Kinetic Combat Eyetoy: Monkey mania Eyetoy Play 3 Eye Toy Play Sports Eye Toy Play Astro Zoo Fantastic Four Fantastic Four Rise of the Silver Surfer Farenheit Flatout Final Fight Streetwise Forbidden Siren 2 Ford Mustang Full Spectrum Warrior G1 Jockey 4 Genji Getaway: Black Monday God of War Gran Turismo 4 Grand Theft Auto: Liberty City Stories Grand Theft Auto: Vice City Stories GrimGrimoire Guitar Hero Rocks the 80's Happy Feet Haunting Ground Hello Kitty Roller Rescue Heroes of the Pacific Incredibles, The Ice Age 2 the Meltdown Incredibles, The (Rise of the Underminer) Jak X: Combat Racing Juiced Justice League Heroes Kingdom Hearts II Lara Croft Tomb Raider: Legend L.A. Rush The Legend of Spyro: A New Beginning The Legend of Spyro: The Eternal Night Let's Make a Soccer Team!

When a group of young punks resembling the leather - jacket wearing, pulp - talking thugs from a 1950s anti-drug film and their floozy girlfriends swing by the establishment, Peggy meets cute with brooding, mascara - wearing Jak (Jonathan Tucker, one of the victims from the Texas Chainsaw Massacre remake).

Repertoire (Alphabetical order by director) Du levande (You, the Living, Roy Andersson, 2007) En kärlekshistoria (A Swedish Love Story, Roy Andersson, 1970) Sånger från andra våningen (Songs from the Second Floor, Roy Andersson, 2000) Les ordres (Michel Brault, 1974) Jagdszenen aus Niederbayern (Hunting Scenes from Bavaria, Peter Fleischman, 1969) La faille (Weak Spot, Peter Fleischman, 1975) Proverka na Dorogakh (Trial on the Road, Aleksei German, 1971) Moy drug Ivan Lapshin (My Friend Ivan Lapshin, Aleksei German, 1984) La Verifica Incerta (Alberto Grifi & Gianfranco Baruchello, 1965) Die linkshändige frau (The Left - Handed Woman, Peter Handke, 1978) Poison (Todd Haynes, 1990) Feng gui lai de ren (Boys from Fengkuei, Hou Hsiao - hsien, 1983) Jak zyc (How to Live, Marcel Lozinski, 1981) The savage eye (Ben Maddow / Sidney Meyers / Joseph Strick, 1960) Kundskabens træ (Tree of Knowledge, Nils Malmros, 1981) Drenge (Boys, Nils Malmros, 1977) Visita ou Memórias e Confissões (Visit or Memories and Confessions, Manoel de Oliveira, 1982/2015) De ofrivilliga (Involuntary, Ruben Östlund, 2008) Minotaur (Nicolás Pereda, 2015) La parmigiana (The Girl from Parma, Antonio Pietrangeli, 1963) Chroniques turcs (Turkish Shorts, Maurice Pialat, 1963) La gueule ouverte (Mouth Agape, Maurice Pialat, 1978) Passe ton bac d'abord (Graduate First, Maurice Pialat, 1978) La maison des bois (Maurice Pialat, 1971) Silvia Prieto (Martin Rejtman, 1999) Entrenamiento Elemental para Actores (Elementary Training for Actors, Martin Rejtman, 2009) Rapado (Martin Rejtman, 1992) Trás - os - Montes (Antonio Reis & Margarida Cordeiro, 1976) Os Verdes Anos (The Green Years, Paulo Rochas, 1963) Sagro Gra (Gianfranco Rosi, 2013) Carriage trade (Warren Sonbert, 1968) Nicht versöhnt oder Es hilft nur Gewalt wo Gewalt herrscht (Not Reconciled, Straub - Huillet, 1965) Idioterne (The Idiots, Lars von Trier, 1998) Im Lauf der Zeit (Kings of the Road, Wim Wenders, 1976) Die Angst des Tormanns beim Elfmeter (Goalie's Anxiety at the Penalty Kick, Wim Wenders, 1971) Summer in the City (Wim Wenders, 1970) Ich war neunzehn (I Was 19, Konrad Wolf, 1968) Ljudi (U Prolazu)(People (In Passing), Lordan Zafranović, 1967) Poslihe Podne (Puska)(Afternoon (The Gun), Lordan Zafranović, 1968) Crni film (Black Film, Želimir Žilnik, 1971)

Apoquel is a JAK - 1 inhibitor that is especially formulated and duly approved by the FDA for use in the control and management of intense itching in dogs.

Being a part of the class of drugs that inhibit the action of a family of enzymes known as the Janus Kinases or JAKs, JAK Inhibitors effectively block the signals generated by various cytokines.

APOQUEL was approved by the U.S. Food and Drug Administration in May 2013 and is the first and only Janus kinase (JAK) inhibitor approved for veterinary use.

Craig, with his skis on, slid onto the ice, scooped Jak up by his harness and tossed him towards what he hoped was the shore.

Developed by Zoetis, APOQUEL is the first Janus kinase (JAK) inhibitor approved for veterinary use that targets the itch and inflammation pathway.

With beaches like Ao Ta Khian and Ao Jak joined by numerous khlongs all situated fairly close together, Kut's southern reaches are great for a day of kayaking.

Machinarium Jak & Daxter HD (Rated by ESRB, I take that as a confirmation).

One of the most eagerly anticipated games of the year is The Last of Us, a PS3 exclusive that is being developed by Naughty Dog who are famous for the Uncharted series and the Jak series.

Jak is by no means a deep character.

The Jak and Daxter Collection has been rated again by the ESRB, but this time for the Playstation Vita.

Oh, and by the way, it looks like Jak and Daxter: The Precursor Legacy will be available to download for the PS4 on August 22 as well.

Jak and Daxter This classic game first introduced in 2001 on the Playstation 2 by Naughty Dog is set in a wonderful fictional universe brimming with a substance called Eco where Jak accidentally turns Daxter into an otter - weasel hybrid and seeks out a way to reverse the transformation.

There was also artwork all other the place, with the star of the show being all these wall paintings by an illustrator who goes by the name of Jon Bugerman, including a loooong video game history time line.Also featured were pieces of original artwork by the creators of Mario and Sonic, cels and production art from Don Bluth's Dragon's lair, and concept art from the likes of Monkey Island, Jak + Daxter and the Sims.»

Ported by Sanzaru Games, this collection puts the trash heap that is the Jak and Daxter port to shame.

I thought the problem was getting eaten by a big fish when you're swimming too far from the shore in Jak & Dexter and figured you could do Just Cause 2, but when you cross the Western end of the map, you pop up at the Eastern end.

Games Developed by Naughty Dog, Inc. 1996 Crash Bandicoot [European] PlayStation 1996 Crash Bandicoot PlayStation 3.5 Stars 1997 Crash Bandicoot 2: Cortex Strikes Back PlayStation 3.5 Stars 1997 Crash Bandicoot 2: Cortex Strikes Back [European] PlayStation 3.5 Stars 2000 Crash Bandicoot 2: Cortex Strikes Back [Greatest Hits] PlayStation 3.5 Stars 1998 Crash Bandicoot: WARPED [European] PlayStation 4 Stars 1998 Crash Bandicoot: WARPED PlayStation 4 Stars 1999 CTR: Crash Team Racing PlayStation 3.5 Stars 1999 CTR: Crash Team Racing [European] PlayStation 3.5 Stars 2000 CTR: Crash Team Racing [Greatest Hits] PlayStation 3.5 Stars 2004 Jak 3 PlayStation 2 3.5 Stars 2005 Jak 3 [Greatest Hits] PlayStation 2 3.5 Stars 2005 Jak 3 [Platinum][European] PlayStation 2 2001 Jak and Daxter: The Precursor Legacy PlayStation 2 3.5 Stars 2001 Jak and Daxter: The Precursor Legacy [European] PlayStation 2 2001 Jak and Daxter: The Precursor Legacy [Japanese] PlayStation 2 2002 Jak and Daxter: The Precursor Legacy [Greatest Hits] PlayStation 2 3.5 Stars 2003 Jak II PlayStation 2 3.5 Stars 2004 Jak II [Greatest Hits] PlayStation 2 3.5 Stars 2004 Jak II: Renegade [Platinum][European] PlayStation 2 2006 Jak X [Platinum][European] PlayStation 2 2005 Jak X: Combat Racing PlayStation 2 3 Stars 2006 Jak X: Combat Racing [Greatest Hits] PlayStation 2 3 Stars 1989 Keef the Thief Apple IIGS 2 Stars 1989 Keef the Thief IBM PC Compatible 2 Stars 2013 The Last of Us PlayStation 3 4 Stars 2013 The Last of Us: Post-Pandemic Edition [GameStop Exclusive] PlayStation 3 4 Stars 2014 The Last of Us: Remastered PlayStation 4 4 Stars 2013 The Last of Us: Survival Edition PlayStation 3 4 Stars 1991 Rings of Power Sega Genesis 3 Stars 2009 Uncharted 2: Among Thieves PlayStation 3 4 Stars 2010 Uncharted 2: Among Thieves — Game of the Year Edition PlayStation 3 4 Stars 2011 Uncharted 3: Drake's Deception PlayStation 3 4 Stars 2011 Uncharted 3: Drake's Deception — Collector's Edition PlayStation 3 4 Stars 2012 Uncharted 3: Drake's Deception — Game of the Year Edition PlayStation 3 4 Stars 2015 Uncharted 4: A Thief's End PlayStation 4 2007 Uncharted: Drake's Fortune PlayStation 3 3.5 Stars 1994 Way of the Warrior 3DO 2.5 Stars

The Last Tinker: City of Colors, a 3D Action Adventure, inspired by classics such as Jak and Daxter and Banjo Kazooie, was released in summer 2014 on PS4 and desktop platforms.

It sounds to me as if Naughty Dog has creatively moved on from Jak and Daxter, and while the company may want to revisit the series, if they're not interested in carrying on the franchise in a style welcomed and expected by the fans, then there's really not much of a point in doing so.

The Arcslinger is developed by Big Red Button Entertainment, which employs some very talented veterans from Naughty Dog, even the founder of the company itself, Big Rafel was an art director at Naughty Dog and was working on projects like Jak and Daxter, Uncharted: Drake's Fortune, and Sonic Boom: Rise of Lyric.

Skate the Sky Film 35 mm film print of clouds in the sky covered with ink, Ho - HoÍs, and Melon juice — filmstrips taped to Tate Turbine Hall ramp and skateboarded over using ollie, kick flip, pop shove - it, acid drop, melon grab, crooked grind, bunny hop, tic tacs, sex change, disco flip — skateboarding performed live for Long Weekend by Thomas Lock, Louis Henderson, Charlotte Brennan, Dion Penman, Sam Griffin, Jak Tonge, Evin Goode and Quantin Paris, clouds shot by Peter West 2009

Skate the Sky Film (35 mm film print of clouds in the sky covered with ink, Ho - Ho's, and Melon juice - filmstrips taped to Tate Turbine Hall ramp and skateboarded over using ollie, kick flip, pop shove - it, acid drop, melon grab, crooked grind, bunny hop, tic tacs, sex change, disco flip - skateboarding performed live for Long Weekend by Thomas Lock, Louis Henderson, Charlotte Brennan, Dion Penman, Sam Griffin, Jak Tonge, Evin Goode and Quantin Paris, clouds shot by Peter West), 2009

, Edited by Marysia Lewandowska and Laurel Ptak, Sternberg Press, Berlin «The Distance of a Day», Motto Books & Chert, Berlin «How to Shoplift Books (Come Rubare Libri)», Automatic Books, Venice «Comment voler des livres / Jak kraść książka», (Polish and French translations of How to Shoplift Books), Automatic Books, Venice «Cómo robber libros / Bogrov», (Danish and Spanish translations of How to Shoplift Books), Automatic Books, Venice «I was Serious, I was Eating Apples», Automatic Books, Venice «Watercolors», Natalie Haüsler and David Horvitz, Eberl Print GmBH, Immenstadt, Bavaria 2012 «Public Access», Publication Studio, Portland, Oregon «Sad, Depressed, People», New Documents, Los Angeles, California 2011 «The Open Daybook», Los Angeles Contemporary Exhibitions, Los Angeles, California «My Grandmother's Recipes», Morova, Poznan, Poland «Volume North + South», Publication Studio, Portland, Oregon 2010 «Everything That Can Happen in a Day», Mark Batty, Los Angeles 2009 «Rarely Seen Bas Jan Ader Film», 2nd Cannons Publications, Los Angeles 2007 «Xiu Xiu: The Polaroid Projects», published by Mark Batty Publisher, ISBN - 10: 0979048656

Burbank, California About Blog The Animation Academy was founded by Charles Zembillas (Character Designer for Crash Bandicoot, Spyro the Dragon and Jak and Daxter) in 1998 and is located in Burbank California.