Sentences with phrase «by mmp»

However, in the presence of the cancer, the linker is cleaved by MMP - 2, which cause the two materials to be separated and the MRI signal switched «ON.»

(b) The MRI signal is turned «ON» when the linker between the two magnetic materials is cleaved by MMP - 2.

They connected the two magnetic materials with a linker that is naturally cleaved by MMP - 2.

«Conventional drugs targeting the enzymes encoded by MMP genes have not been successful in the clinic due to adverse side effects,» said Rahme.

Not exact matches

Changes to competition laws (milk wars discussion and recommendations relating to MMP (introduce effects test), predatory pricing (recommend Minister direct ACCC to investigate Coles for breach of s 46 relating to predatory pricing), unconscionable conduct (suggest it be defined), statutory duty of good faith, unfair contract terms (seeks «recognition of the competitive disadvantage faced by farmers» and extension of unfair contract terms protection to small business), collective bargaining (seeks relaxation of public interest test for boycott approvals in agriculture markets, increase «ability for peak bodies to commence and progress collective bargaining and boycott applications» on behalf of members - and further dairy specific recommendations, ACCC divestiture power (wants ACCC to have similar divestiture powers to Comp Commission in UK - «simpler process of divestiture», ACCC monitoring powers (wants Minister to direct ACCC to use price monitoring powers to «monitor prices, costs and profits relating to the supply of drinking milk») and mandatory code of conduct (wants mandatory code and «Ombudsman with teeth to ensure compliance»)-RRB-.

Once they've been enacted by ordinary legislation - STV in Ireland and Tasmania, AV in mainland Australia, MMP in Germany, runoff ballots in France - and the voters have gotten used to the new system, no politician advocating a return to FPTP is taken seriously.)

In August 2012, the initial report on a review of the MMP system by the Electoral Commission recommended abolishing the one electorate seat threshold, meaning a party winning an electorate seat but not crossing the 5 % threshold (which the same report recommends lowering to 4 %) is only awarded that electorate seat.

[7] It was the way that compensatory seats were allocated that made their report the origin of the additional member system, the term which the report also invented, which was then applied along with the much older «mixed system» by English - speaking writers on voting systems to West Germany's system and similar models until mixed member proportional (MMP) was invented for the adoption of the German system proposed for New Zealand in a royal commission report in 1986, which would explain why AMS and MMP have been used as synonyms.

These proteins, known as matrix metalloproteinases (MMPs), help cancer cells escape their original locations by cutting through proteins of the extracellular matrix, which normally holds cells in place.

Griffiths also notes that emphysema, a lung disease common in smokers, is marked by a loss of connective tissue and may be related to increased MMP - 1 levels.

Moradian - Oldak will couple the MMP - 20 discovery with another study published Nov. 2 in the Journal of Biomedical Engineering and Informatics, which concluded an amelogenin - chitosan hydrogel could repair early tooth decay by growing an enamel - like layer that reduces lesions by up to 70 percent.

Further, the researchers found that MMP - 9 can be detected not just in lumbar 5 neurons, but also in other types of motor neurons affected by ALS.

In another experiment, the researchers tested whether MMP - 9 has a functional role in ALS by crossing MMP - 9 knockout mice with SOD1 mutant mice (a standard mouse model of ALS).

To detect this sort of enzyme, the researchers designed nanoparticles coated with small protein fragments called peptides that can be cleaved by particular proteases called MMPs.

MMPs cleave the peptides to liberate tiny reporter fragments, which are then filtered out by the kidney and concentrated in the urine, where they can be detected using various methods, including a simple paper - based test.

«Most MMPs are made by cells that surround and support a tumor, not by the tumor itself, as we see in pancreatic cancer,» Dr. Radisky says.

(a) MMP - 2 represented by little scissors is an enzyme that cleaves the extracellular matrix and allows cancer to metastasize to other tissues.

In particular, researchers know that collagen is broken down by a certain class of enzymes called matrix metalloproteinases (MMPs), but exactly how they did this remained somewhat of a mystery, until now.

Her research showed that degeneration is caused by perturbations in the epidermis due to an increase in matrix - metalloproteinase 13 (MMP - 13), an enzyme that degrades the collagen, or «glue,» between the cells.

The increase in MMP - 13 activity could be triggered by oxidative stress, which is also a hallmark of diabetic peripheral neuropathy.

MMPs are required for the recruitment of antigen - nonspecific mononuclear cells into the liver by CTLs.

The treatment of neuropathy with MMP - 13 - targeting compounds is the subject of a provisional patent filed by the MDI Biological Laboratory in January.

Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels.

EphA2 cleavage by MT1 - MMP triggers single cancer cell invasion via homotypic cell repulsion.

MMP - 14 is necessary but not sufficient for invasion of three - dimensional collagen by human muscle satellite cells.

(29) This has led to the hypothesis that the great majority of such cells are destroyed over the lifetime by innate immunity, and that the specific senescent cells that do accumulate with aging are precisely those who had variants that allow MMP overexpression, in a kind of «one - off,» very temporally - extended kind of selection process.

Dr. Campisi has found instead that a minority of senescent cells evade destruction by secreting high levels of matrix metalloproteinases (MMPs), which cleave MICA / B ligands and thereby prevent NKG2D binding.

Based upon these data, we hypothesize that strain - selective activation of NF - kB and / or MAPK by H. pylori cag + strains regulates MMP - 7 expression, which may contribute to the augmentation in carcinogenic risk associated with these strains by attenuating apoptosis within chronically colonized mucosa.

Our experiments have recently shown that MMP - 7 is detected exclusively in human mucosa colonized by cag + strains, and these same H. pylori strains selectively induce MMP - 7 in vitro through cag - mediated activation of NF - kB and MAPK.

Since invasion is dependent on extracellular matrix remodeling capabilities, this inhibitory effect strongly suggested that the two key extracellular membrane remodeling enzymes expressed by endothelial cells, namely, MMP - 2 and uPA could be other main key targets of the pharmacological action of kahweol on endothelial cells.

We also demonstrate the inhibitory effect of kahweol on the endothelial cell potential to remodel extracellular matrix by targeting two key molecules involved in the process, MMP - 2 and uPA.

MMP - 2 and uPA are extracellular matrix remodeling ezymes expressed by endothelial cells and involved in angiogenesis.

Interferon --LCB- gamma -RCB-- activated STAT - 1 -LCB- alpha -RCB- suppresses MMP - 9 gene transcription by sequestration of the coactivators CBP / p300

However, fibrillar Aß preparations lead to similar decrease in MMP as oligomeric Aß, suggesting that mitochondrial dysfunction is mediated by both species in contrast to defects in long - term potentiation (LTP) where only oligomeric Aß inhibits LTP [59].

Changes in oxygen consumption and mitochondrial respiration and a drop in MMP levels were not detectable before an age of 24 months in these animals, indicating that Aß might initiate mitochondrial damage which is further accelerated by hyperphosphorylated tau.

This is again due to the collapse of the wholesale market in the 1990's which was almost all mass market paperback, the need then to raise prices on mmps as they moved more heavily into the bookstores, and the costs involved with mmp re the returns system (mmp are «returned» for full refund by ripping off their front covers, returning those to the publishers and the rest of the books are pulped because that's cheaper than shipping those units back, which has been a real mess.)

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MMP protects your vehicle from the cost of expensive repairs not covered by your manufacturer's warranty.

mmp format, which is used by various mind mapping applications, and can be imported into the (wonderful and free) Freemind application.