The product of the reaction catalyzed
by MTHFR converts homocysteine (a potentially toxic amino acid) to methionine (a useful and necessary amino acid).
Nutrients available for upgrades are the master antioxidant Glutathione, Vitamin C, Vitamin D, Methylated Folate (L -5-MTHF) for individuals with the fatigue caused
by MTHFR genetic abberation.
Methylation capability, often assessed
by MTHFR genotype, is a crucial piece of the puzzle for many with autism.
Not exact matches
The likelihood of adverse events is higher is individuals who are
MTHFR (methylenetetrahydrofolate reductase) positive and should be avoided
by them.
MTHFR is an enzyme that adds a methyl group to folic acid to make it usable
by the body.
(This could be skewed
by people who have mutations in their
MTHFR gene (s).
If you are a person who has a family history of spinal bifida, depression, migraines, thyroid disorders, stroke, dementia and angina, high blood pressure or elevated homocysteiene or cardiovascular disease strongly consider being tested for a genetic variance (
MTHFR) that is easily detected and corrected
by correct methyfolate supplementation.
The
MTHFR enzyme breaks folic acid down into L - methylfolate to make it usable
by the body.
Here is a link to an article
By Dr. Ben Lynch an expert on
MTHFR and a Naturopathic Doctor.
It is estimated that over half of the population has some form of
MTHFR, which affects the way certain nutrients, like B vitamins, are (or are not) metabolized
by the liver.
Uhm — And then, the production of — you know — Glutathione is so important uhm — you know — that plays a role or — and it's affected
by other polymorphisms, which that — You know —
MTHFR is a polymorphism.
I know
MTHFR affects the form of B12 and Folate that can be used
by the body.
Folic acid on the other hand, can not be absorbed
by those with the
MTHFR mutation, and has been shown to prevent the absorption of whole food folate.
Especially good for those with
mthfr issues... it has a huge folate profile of different forms so your body can «select» the best form for you to digest without conversion
by the liver.
B12 might also be high due to an active
MTHFR mutation along with an active COMT mutation, so patients tend to avoid the synthetic supplemental version of B12 called cyanocobalamin and instead favor the methylcobalamin (methylB12) or adenosylcobalamin (also the active form, but used
by your mitochondria), but they will need adequate folate supplementation.
NOTE FROM JANIE BOWTHORPE: I have one copy of the 1298
MTHFR mutation and never had a problem, until the stress of mold exposure followed
by having to detox high copper seemed to make it come alive, along with mutations with COMT, MTRR and more.
So the short answer to your question is no, you can not compensate for an
MTHFR gene variant
by taking more folate in your diet.
Dubbed the «The Methyl Queen»
by colleagues and the winner of the 2014 NANP Impact Award (National Association of Nutrition Professionals) based on her research & training programs on
MTHFR and Methylation.
This prenatal was created
by one of the world's
MTHFR experts, Dr. Ben Lynch.
Fortunately, one can order confidential tests that will not be reported to insurance
by using online lab testing services, like Ulta Labs for Homocysteine or Ulta Labs
MTHFR gene variation test.