Sentences with phrase «by nucleic acid»

FLT3 TKD mutations are caused by nucleic acid substitutions and / or deletions that result in a change in the amino acid sequence in this highly conserved catalytic center.

Screening the Blood Supply for West Nile Virus RNA by Nucleic Acid Amplification Testing.

Were there not a certain invariance about the way in which carbon atoms bond with others under identical conditions, or about the manner in which protein synthesis is charted and activated by nucleic acids, life would be impossible altogether.

The apparent gap between nonliving and living has now been bridged by nucleic acids, a class of polymeric organic molecules composed of a succession of small units (nucleotides) of four sorts, the order of which determines an indefinitely large number of different specificities.

Not exact matches

One way to shut down the communication link is through a snippet of RNA called «antisense» — which binds to the messenger RNA (a «sense» - making strip of nucleic acids) that is transcribed by a given stretch of DNA.

Out of the Gordon Conference on nucleic acids in the summer of 1973 came an open letter to Science; the establishment (in October 1974) by the National Institutes of Health of the Recombinant DNA Molecule Program Advisory Committee; and in February 1975 the now - famous international conference at the Asilomar Conference Center in California, where a reluctant decision was made by scientists to declare a temporary moratorium on certain kinds of DNA research.

Even if the a priori probabilities of its happening the first time are virtually zero, Jacques Monod holds that it still might happen nonetheless.1 Furthermore, it has been demonstrated that the amino and nucleic acids which life requires could already have been made plentifully available by rather «impersonal» natural processes.

The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.

They naturally enter cells by engaging scavenger receptors that are not recognized by linear nucleic acids.

Further research by Stanley and others established that a virus consists of nucleic acids (DNA or RNA) enclosed in a protein coat that may also shelter viral proteins involved in infection.

In 2009, a team led by Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, uncovered evidence of the process in Neanderthal and mammoth DNA (Nucleic Acids Research, DOI: 10.1093 / nar / gkp1163).

This chemically enhanced X-ray technique revealed that DNA was composed of two complementary strands of nucleic acids linked by chemical bonds on a ladder - like chain.

By the time he obtained his master's degree, new research suggested «that there was a system in the plant... able to recognize foreign nucleic acids and deal with them... in a sequence - specific manner,» Voinnet says.

Now, Wyss Institute researchers led by Church have developed a new suite of such sensors, reported in Nucleic Acids Research journal, that not only increase the number of cellular «switches and levers» that scientists can use for complex genetic re-programming, but also respond to valuable products such as renewable plastics or costly pharmaceuticals and give microbes a voice to report on their own efficiency in making these products.

Anderson and Langer have previously developed nanoparticles, now in clinical development, that can deliver siRNA to liver cells called hepatocytes by coating the nucleic acids in fatty materials called lipidoids.

It also hints at why proteins were eventually preferred by evolution over nucleic acids as catalysts in biology: proteins offer much more ability to «tune» their «jiggling and wiggling» and their response to chemical reactions.

The find highlights how ancient viruses can more easily be identified by their proteins than their more commonly studied nucleic acids, such as DNA or RNA.

«Recovering nucleic acids from ancient viruses is extremely difficult and plagued by contamination,» notes Angelique Corthals, a forensic anthropologist at the City University of New York in New York City, who was not involved in the study.

Led by Dr. Peter Glazer, chair of therapeutic radiology, Dr. Mark Saltzman, chair of biomedical engineering, and Dr. Marie Egan, professor of pediatrics and of cellular and molecular physiology, the collaborative team used synthetic molecules similar to DNA — called peptide nucleic acids, or PNAs — as well as donor DNA, to edit the genetic defect.

By injecting short nucleic acids into rats, researchers have blocked an enzyme linked to swelling and tissue damage in the lungs.

«By selectively targeting the source of the immune activation rather than shutting off the innate immune system downstream, these nucleic acid scavengers are able to limit pathological inflammation without compromising one's ability to fight a viral infection,» Sullenger said.

Intrigued by the ability of certain polymers to mop up DNA and RNA for gene transfer, Sullenger and colleagues tested the idea that these chemical compounds might also be effective targeting such nucleic acids as they arise in cell death.

Clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR - associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide the silencing of invading nucleic acids.

Church says base editing should be evaluated «case - by - case» for whether it offers advantages over CRISPR and other technologies that alter nucleic acids.

Another idea is to probe the mother's bloodstream for cells and nucleic acids shed by the placenta as a window into the function of the organ.

Currently, acute infections are predominantly confirmed by detecting viral nucleic acid in blood and urine.

All tests detect viral RNA (ribonucleic acid) by means of the so - called polymerase chain reaction (PCR) which is a standard method for detecting nucleic acids.

However the team from the Krebs Institute for Nucleic Acids at the University of Sheffield found that the key to preventing resistance to a common class of chemotherapy used to treat breast and colon cancer is to change the speed in which the cancer cells repair damage to their DNA that is introduced by chemotherapy.

Modern molecular technologies (genomics and other omics), through comparing nucleic acid and amino acid sequences across living species, are enabling the identification of genetic components and patterns stingily conserved by evolution, from those in which times of evolutionary branching of the tree of life can be inferred.

TNGB collects, stores and distributes high quality biological materials (nucleic acids, cell lines and tissue samples) linked to relevant clinical and genetic data from patients affected by inherited diseases.

Reverse transfection — the method whereby nucleic acids are localized on a substrate prior to addition of cells — was first developed in 2001 at Whitehead Institute for Biomedical Research by Junald Ziauddin and David M. Sabatini.

More information: Kalina Paunovska et al, A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation., Nano Letters (2018).

The Deaconescu Laboratory focuses on structural studies by X-ray crystallography, small - angle X-ray scattering and electron microscopy of protein - protein and protein - nucleic acid complexes, particularly those involved in DNA repair and transcriptional regulation.

Nucleic Acid - Modified Nanostructures as Programmable Atom Equivalents: Forging a New «Table of Elements by Robert J. Macfarlane, Matthew N. O'Brien, Dr. Sarah Hurst Petrosko, and Prof. Chad A. Mirkin.

This often involves restoring injured nucleic acids back to their native form or replenishing proteins and lipids once damaged by harmful byproducts of metabolism.

Proteins, nucleic acids and their complexes are then crystallized and analysed by X-ray diffraction, using synchrotron radiation.

Characterization of the nucleic acid binding region of adenovirus DNA binding protein by partial proteolysis and photochemical cross-linking

Aptamer - quantum dot (APT - QD) bioconjugates were synthesized by conjugating cadmium - telluride quantum dots (QDs, semiconductor nanoparticles) to aptamers (nucleic - acid based ligands), by amide crosslinking.

Stepwise synthesis of a nucleic acid to determine nucleotide sequences; inspired the DNA sequencing technique by F.Sanger (Sanger, Nobel Prize Lecture 2004).

DNA (DeoxyriboNucleic Acid) a molecule composed of two chains of nucleic acid bases held together by hydrogen bonds in a pattern resembling a flexible twisted ladAcid) a molecule composed of two chains of nucleic acid bases held together by hydrogen bonds in a pattern resembling a flexible twisted ladacid bases held together by hydrogen bonds in a pattern resembling a flexible twisted ladder.

Here we present fCCAC, an application of functional canonical correlation analysis to assess covariance of nucleic acid sequencing datasets such as chromatin immunoprecipitation followed by deep sequencing (ChIP - seq).

The study was led by Olof Emanuelsson, KTH Royal Institute of Technology / SciLifeLab and Jens Sundström, SLU Swedish University of Agricultural Sciences, and published in Nucleic Acids Research.

We developed a way of getting siRNAs into epithelial cells by either mixing them with a transfection lipid used to introduce exogenous nucleic acids into cells in the lab or by adding a cholesterol tag to the end of the RNA sequence that allowed the RNA to be taken up into cells.

Additional «- omics» data streams include: transcriptomics, the pattern of RNA synthesis from DNA; proteomics, the distribution of proteins in cells; interactomics, the patterns of protein - protein and protein — nucleic acid interactions; and metabolomics, the nature and traffic patterns of transformations of small molecules by the biochemical pathways active in cells.

PCR products were visualized by blue light after electrophoresis on a 2.5 % agarose gel containing 1 × GelStar ® Nucleic Acid Gel Stain (Lonza, Breda, The Netherlands) in 1 × Tris - borate buffer (pH 8.0).

Rearrangements in the mtDNA will be monitored by long extension - PCR (LX - PCR) and mtDNA point mutations will be analyzed by direct mtDNA sequencing and by Protein Nucleic Acid (PNA)- competitive PCR (PNA - PCR).

Led by Dr. Peter Glazer, chair of therapeutic radiology, Mark Saltzman, chair of biomedical engineering, and Dr. Marie Egan, professor of pediatrics and of cellular and molecular physiology, the collaborative team used synthetic molecules similar to DNA — called peptide nucleic acids, or PNAs — as well as donor DNA, to edit the genetic defect.

The sample was injected with live cell nucleic acid stain [STYO 13] which is taken up by live bacteria and shows as bright green when viewed using a 500 nm - long pass emission filter for fluorescence detection.

Vitamin C protects the body's lipids (fats), proteins, nucleic acids (RNA and DNA), and carbohydrates from damage by free radicals.

One needs a little nitrogen and phosphorus to make amino and nucleic acids (which may be adequately supplied by decomposing dead trees.