Sentences with phrase «by a chemotherapy drug»

Moreover, in some cases, pancreatic cancer cells can even repair damage to their DNA caused by the chemotherapy drugs that do get into the tumor, further protecting themselves.

Linking the differentiation process with organ - on - a-chip technology pioneered by his team, the researchers went on to engineer the first in vitro model of the human glomerulus, demonstrating effective and selective filtration of blood proteins and podocyte toxicity induced by a chemotherapy drug in vitro.

Not exact matches

Those drugs in combination reduce patients «risk of death or their cancer progressing by 42 percent versus chemotherapy, still beating Wall Street «s estimates.

For instance, most common adult solid tumors that are not cured by surgical removal are resistant to chemotherapy or radiation control, yet drug therapy is frequently offered as a «possibly effective» treatment because both patient and physician want to believe it so.

Another study from Nigeria published in December of 2017 is titled Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute chemotherapy oxidative nephrotoxicity induced by anticancer drug methotrexate in rats.

Breastfeeding after chemotherapy has been completed may be possible, either by relactation or as a result of another pregnancy, depending upon the drugs that were used.

Chemotherapy (drug treatment) was later developed to destroy small tumour growths that were not treatable by other methods.

One of those licenses went to Michael Hackett, a UNC doctoral student who got an idea 2 years ago for a potential commercial drug: to trick tumors into absorbing chemotherapy drugs by designing a molecular Trojan horse.

Doxorubicin is a chemotherapy drug used to treat a wide range of cancers by preventing cancer cells from replicating.

Chemotherapy drugs designed to kill tumors may actually encourage ovarian cancer by stimulating the growth of cells that give rise to the malignancy, a new study finds.

So far there's no approved drug on the market that reverses cancer chemotherapy resistance caused by P - glycoprotein, or P - gp for short, said Vogel, a biochemistry professor at SMU.

McKenna and his team have identified four different drugs — including the anti-HIV drug nelfinavir — that can disrupt the process by which hypoxia occurs, restoring proper blood flow to the tumours and making them more vulnerable to chemotherapy (Cancer Research, DOI: 10.1158 / 0008 - 5472.

That injection puts the «gas on» the immune system followed by a second injection of a drug being developed as a chemotherapy.

Potti and his colleagues began by testing chemotherapy drugs on cultured cell lines from human tumors, such as from the lung, breast, or ovary.

«By administering chemotherapy within this «therapeutic window,» oncologists could apply a lower dose of chemotherapy drugs to patients, with the potential for an improved treatment outcome — all while minimizing drug toxicity to healthy organs,» He said.

Chemotherapy drugs are often designed to kill off malignant cells by damaging their DNA until they transition to a programmed death mode called apoptosis.

In one example highlighted by the researchers, mouse models of T - ALL were treated either with a combination of mTOR inhibitor pp242 and the chemotherapy drug AraC, or they were treated with just AraC or pp242.

«In pancreatic, ovarian and liver cancers, we hope that by adding anti-cancer stem cell drugs to standard of care, we can control proliferating cells within the tumor that could otherwise help the tumor regenerate in the face of existing chemotherapies.»

Most cancer chemotherapy relies on cells absorbing drugs by diffusion across the cell membrane.

A team of researchers led by Dr. Jian Zuo screened over 4,000 drugs for their ability to protect cochlear cells from the chemotherapy agent cisplatin.

The findings, announced online in the journal Antimicrobial Agents and Chemotherapy and funded by the National Institutes of Health, provide a needed boost to the field of antibiotic development, which has been limited in the last four decades and outpaced by the rise of drug - resistant bacterial strains.

An early - stage clinical study by another institution, published in the Lancet Oncology in May 2016, combined chemotherapy with an experimental drug that blocks CCR2, a receptor on monocytes and macrophages whose activation stimulates these cells to infiltrate tumors.

Potential cancer treatments are loitering in the wings as clinical trials are delayed by widespread shortages of common chemotherapy drugs.

By kick - starting a gene that is naturally inactivated, chemotherapy drugs could help reverse a genetic brain disorder that is sometimes mistaken for autism or cerebral palsy.

But a new study reports that these tiny flecks of carbon can shrink tumors in mice by delivering chemotherapy drugs to cancer cells.

As part of the project, announced last week by Kenneth Hagemann, director of the Pentagon's Defense Nuclear Agency, 24 soldiers from Brooks Air Force Base in Texas are taking prescription drugs — ondansetron hydrochloride and granisetron hydrochloride — that are given to cancer patients undergoing radiotherapy or chemotherapy.

«Drug could limit spread of deadly brain tumors: Study shows PPF could help treat glioblastomas by sensitizing tumors to chemotherapy, radiation treatments.»

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

A phase I clinical trial conducted by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal cell carcinoma and colon cancer, was clinically safe and inhibited autophagy.

A drug recently developed by Pfizer, crizotinib, targets ALK and is currently given to patients with ALK positive lung cancer when their cancer has worsened after initial chemotherapy.

Enzalutamide, which is taken as four pills once per day, is already approved by the Food and Drug Administration (FDA) for men whose disease has not been stopped by other treatments including, surgery, radiation, androgen deprivation therapy and chemotherapy.

The chemotherapy drug bortezomib (marketed by Millennium Pharmaceuticals under the brand name Velcade) takes advantage of this reliance and targets the proteasome's function.

Dronabinol was approved by the Food and Drug Administration more than 25 years ago to treat nausea and vomiting in chemotherapy patients.

The researchers then exposed cells from each of these lines to a panel of 31 different drug treatments — including 23 chemotherapy compounds approved by the FDA for breast and ovarian cancers, six targeted cancer drugs, and two common drug combinations.

«Since 95 percent of cancer patients still get chemo, we realized we could make a major impact on cancer treatment by helping clinicians prescribe the right chemotherapy drug,» said Sourav Bandyopadhyay, PhD, a professor of bioengineering and therapeutic sciences in UCSF's Schools of Pharmacy and Medicine and senior author on the new study.

By controlling the timing of the interaction, researchers could pinpoint delivery of the drug to a precise location, thus preventing side common side effects of chemotherapy, such as hair loss or cardiac toxicity.

As part of the new study, the researchers showed that intact axons without Phr1 were protected from the damage caused by vincristine, a chemotherapy drug used to treat leukemia, neuroblastoma, Hodgkin's disease and non-Hodgkin's lymphoma, among other cancers.

By contrast, a signal of tumor activity increased sixty-fold in mice treated with the widely used chemotherapy drug gemcitabine.

He published another study in August 2015, showing that resistance to the chemotherapy drug doxorubicin is likewise increased by ALAN.

They confirmed this by showing that tumor growth was reduced in mice treated with an antibody drug that targets TIM - 3 and the chemotherapy agent paclitaxel, as compared to treatment with paclitaxel alone.

This study, conducted by the Gynecologic Oncology Group, a cooperative group funded by the National Cancer Institute, was the second to test bevacizumab under these conditions (first chemotherapy for platinum - sensitive recurrence), a use for which bevacizumab is not currently approved by the Food and Drug Administration.

The study by researchers at King's College Hospital and the University of Southampton suggests that adding nutraceuticals to chemotherapy cycles may improve the effectiveness of conventional drugs, particularly in hard to treat cancers, such as pancreatic cancer.

The drug, birinapant, sensitizes the CA125 - negative cells to the chemotherapy by restoring apoptosis, or programmed cell death, said Dr. Sanaz Memarzadeh, a senior author of the study and a UCLA gynecologic cancer surgeon.

The period of time before ovarian cancer recurred (called progression - free survival) improved by nearly 3.5 months with the additional drug (13.8 months compared with 10.4 months for the woman on chemotherapy alone).

In animal studies and early clinical trials, the drug known as Epo (for erythropoietin) appeared to counteract anemia caused by radiation and chemotherapy.

They analyzed the association between body mass index (weight divided by height) and progression - free survival (PFS) and overall survival (OS) in six independent cohorts of patients treated with targeted therapy, immunotherapy or chemotherapy in pivotal trials that led to FDA approval of these drugs.

Brenneman benefited from her colleagues» support during the 2 years she was weakened by chemotherapy and drug treatments.

A similar antibody - drug conjugate approach is used by the breast cancer agent T - DM1, which attaches chemotherapy to an antibody that seeks the HER2 protein in HER2 + breast cancers.

NEW HOPE AGAINST RESISTANT BREAST CANCER: Ixabepilone, a compound being investigated by Bristol - Myers Squibb, shows some encouraging effectiveness against metastatic breast cancers that are resistant to three other standard chemotherapy drugs (anthracycline, taxane and capecitabine).

This therapeutic effect was enhanced by combining the Angiopoietin - 2 antibody with a so - called metronomic chemotherapy: In this kind of therapy, chemotherapeutic drugs are given continuously at much lower dose as in the classical high - dose chemotherapy.