If the technique proves effective, the researchers say, it might be used for treating other types of diseases
caused by single gene mutations.
While the disease is caused
by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiple cellular processes.
Previous research has shown that a protein
produced by a single gene can potentially have different functions in a cell depending on the proteins with which it interacts.
Rather than being
triggered by a single gene mutation, the tumors are caused by too many or too few copies of a gene in a person's cells.
In the intervening years, we have come to realize that many of the most interesting and important phenomena in human biology are not
caused by any single gene.
«Most PRAs, including the one in Phalenes and Papillons, are recessive and caused
by single gene defects and small sample numbers can lead to breakthroughs.
But in a surprising find, it appears that in flies all these acts of gallantry are controlled
by a single gene active in small clusters of cells in the fly brain.
However, GenePeeks's patent on the technique provides for the screening of any trait, whether or not its genetic basis is currently understood, and whether it is
influenced by a single gene or by many (see «Meet your unborn child — before it's even conceived «-RRB-: it cites height, skin colour, neuroticism and breast size as future possibilities.
The team of researchers in collaboration with Patricia Okubura, a USDA - ARS research geneticist, confirmed that resistance was
conferred by a single gene.
This means that it is not associated with the sex chromosomes, but simply
determined by a single gene that one parent can pass to an offspring, the result having varying degrees of severity.
Rare, deadly, and caused
by a single gene mutation, it was a perfect proof - of - principle condition for anyone seeking to replace damaged DNA with genes that did the job.
Because disease organisms mutate quickly to overcome crop resistance
controlled by single genes, researchers are rushing to identify new resistance genes and to incorporate multiple genes into high - yielding varieties, according to Ravi Singh, CIMMYT wheat scientist who participated in the reported study.
Segregation analysis may be sensitive to deviations from normality of the trait distribution, when such deviations are not
caused by a single gene (Lynch and Walsh, 1998).
Because Huntington's is determined
by a single gene, Liu was able to easily isolate its effects on the birds.
It is caused
by a single gene mutation that results in the production of mutant huntingtin protein.
Unlike some other common vision disorders, such as age - related macular degneration, color blindness is a heritable disorder caused
by a single gene that is defective or absent.
Researchers studying three families with the same unusual sleep pattern have uncovered the first hereditary sleep disorder in humans caused
by a single gene.
Genetic analysis and DNA sequencing revealed that Dun versus non-dun colour is determined
by a single gene that codes for the T - box 3 (TBX3) transcription factor.
Semenza's team uncovered the mitochondrial mechanism in a study of Von Hippel - Lindau (VHL) syndrome, caused
by a single gene mutation and characterized by the tendency to develop tumors in many parts of the body, including the kidney, brain and adrenal glands.
But human altruism can not possibly be controlled
by a single gene, and different genes that might produce altruistic behavior probably interact, making the kin selection equation quite a bit more complicated.