Ultimately, Wars2 provides researchers and pharmaceutical companies a fresh new target for developing treatments for diseases characterized
by abnormal blood vessel growth that may be more effective and specific or complementary to what is currently available.
Since the majority of severe visual loss is caused
by abnormal blood vessels growing beneath the retina, a massive effort is underway to identify methods of arresting this process.
Not exact matches
Two protein molecules that fit together as lock and key seem to promote the
abnormal formation of
blood vessels in joints affected
by rheumatoid arthritis, according to researchers at the University of Illinois at Chicago College of Medicine, who found that the substances are present at higher levels in the joints of patients affected
by the disease.
Earlier research
by other scientists has shown that the drug verteporfin, used to treat
abnormal blood vessel formation in the eye, acts on the YAP pathway inhibiting the protein's YAP function.
The device can treat either form of age - related macular degeneration: the dry stage, where the delicate tissues of the macula become thinned and slowly lose function, or the less common wet stage that's caused
by the growth of
abnormal blood vessels behind the macula.
In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive
by normalizing the
abnormal blood vessels in the tumor,» says Patrizia Agostinis.
However, a recent study
by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the
abnormal blood vessels in tumors.
Many diseases are characterised
by abnormal or poor
blood vessel formation.
Linda Shavit, MD (University College London Medical School, in the UK, and Shaare Zedek Medical Center, in Israel) and her colleagues wondered whether the heart problems experienced
by kidney stone formers might be due to
abnormal deposits of calcium in their
blood vessels.
Roughly 20 percent of patients with age - related macular degeneration suffer from
abnormal blood vessel growth and vascular leakage, says Campochiaro, and so may be helped
by this new therapy, if it proves to work in clinical trials.
Experts believe migraine headaches are caused
by abnormal brain activity, including dilation and constriction of the
blood vessels within the brain.
When this breakdown happens, the immune system responds
by releasing products that cause an inflammatory reaction, activating
abnormal clotting in the mother's lungs and
blood vessels that can result in a serious
blood - clotting disorder known as disseminated intravascular coagulation.
High
blood pressure refers to the
abnormal elevation of the pressure exerted
by blood — specifically
blood in the arteries — against the walls of the
blood vessels and the organs those
vessels supply.
This is an
abnormal blood vessel that allows the
blood to bypass the liver, preventing
blood to get cleansed
by one of the body's filters (the liver).
Conversly, the «wet» form of macular degeneration is characterized
by the growth of
abnormal blood vessels from the choroid underneath the macula which then go on to create «blind spots» in a patient's field of vision.