Their analysis of data in previous studies done by The Cancer Genome Atlas group have shown that the types of abnormalmethylation levels they found are lower in smokers who have quit for more than 10 years than those who have not quit.
Defects in methylation also cause the rare chromosomal disorders Angelman syndrome and Beckwith — Wiedemann syndrome — both of these complex congenital afflictions are characterized byabnormal birth weight.