Sentences with phrase «by abnormal protein»

Familial amyloid polyneuropathy is characterized by abnormal protein deposits that can affect the nerves and other functions of the body.

The dementia in the other half appeared to have been caused by abnormal protein deposits (known as Lewy bodies), stroke - related tissue death (microinfarcts), cell damage, or some combination thereof.

Mad cow is the common name for bovine spongiform encephalopathy (BSE), a fatal disease caused by abnormal proteins (prions) in the brain and nervous system.

What these illnesses have in common is that they're caused by abnormal proteins that accumulate in or between brain cells to form plaques, producing damage that causes mental decline and early death.

What these illnesses have in common is that they're caused by abnormal proteins that accummulate in or between brain cells to form plaques, producing damage that causes mental decline and early death.

Not exact matches

This autoimmune disease is caused by an abnormal response to gluten, a protein found in grains such as wheat, rye, and barley.

When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated for abruption.In this large, population - based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.

Two protein molecules that fit together as lock and key seem to promote the abnormal formation of blood vessels in joints affected by rheumatoid arthritis, according to researchers at the University of Illinois at Chicago College of Medicine, who found that the substances are present at higher levels in the joints of patients affected by the disease.

The researchers have now provided further evidence for this new theory by showing that the abnormal protein coded for this genetic disorder can be transmitted to normal animals by the injection of diseased cells into their brain.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

HD is caused by a mutation in the human HTT gene that results in an abnormal expansion and misfolding of the corresponding huntingtin protein.

FA is caused by reduced expression of a mitochondrial protein called frataxin (FXN) due to a two mutated or abnormal copies of the FXN gene.

Coeliac disease is caused by an abnormal reaction to gliadin, a gluten protein found in wheat (and similar proteins of the tribe Triticeae which includes other cultivars such as barley and rye).

According to the proposal, called the amyloid hypothesis, Alzheimer's disease, estimated to affect more than 5 million people in the United States alone, is caused by abnormal buildup of A-beta protein in the brain.

Earlier research by other scientists has shown that the drug verteporfin, used to treat abnormal blood vessel formation in the eye, acts on the YAP pathway inhibiting the protein's YAP function.

Multiple myeloma is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein.

Published in the March 31 advance online issue of Cell, their findings reveal that circular RNAs — like their protein counterparts — are also affected by genomic rearrangements in cancer, resulting in abnormal fusions.

An abnormal protein, left, is intercepted by the UW's compound that can bind to the toxic protein and neutralize it, as shown at right.

The test requires removing cerebrospinal fluid (CSF) from patients by means of a spinal tap, putting samples into a bath of normally shaped prion proteins, and agitating the solution to encourage any abnormal prion «seeds» in the tissue to latch onto the regular proteins.

For nearly 30 years, researchers have gathered evidence that a group of bizarre, fatal brain diseases — including mad cow and its human equivalent, Creutzfeldt - Jakob disease — are caused not by a virus or bacterium but by an abnormal form of a protein, called a prion.

Gambetti, who was not involved in the new study, is co-author on a second NEJM paper appearing online today that shows that an assay similar to the CSF — based RT - QuIC test can pick up very small amounts of abnormal prion protein in the urine of people who have contracted a rare variant of CJD that is transmitted by consuming contaminated meat.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

«How nerve cells are damaged by accumulation of abnormal proteins.»

In most cases, CTE is thought to be caused by repeated blows to the head, which damage brain tissue and lead to a buildup of an abnormal protein called tau, according to the CTE Center.

Both types of dementia (memory and language) can be caused by an accumulation of beta - amyloid, an abnormal toxic protein in the brain.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

Other genetic defects associated with hypertrophic cardiomyopathy — six different genes have been linked to the disease — may work similarly by producing abnormal proteins involved in contraction, says Sweeney.

The researchers also discovered that c9RAN proteins produced by the abnormal RNA can be measured in the spinal fluid of ALS patients.

The Max Planck scientists could also show that a toxic protein related to the abnormal, aggregate - forming protein «huntingtin» of patients with the neurodegenerative Huntington's disease is efficiently destroyed by the newly identified pathway.

«Our results indicate that exercise may slow the progression of Parkinson's disease by turning on the protective gene DJ - 1 and thereby preventing abnormal protein accumulation in brain,» Freed said.

A new study by Columbia University Medical Center (CUMC) researchers strongly supports the latter, demonstrating that abnormal tau protein, a key feature of the neurofibrillary tangles seen in the brains of those with Alzheimer's, propagates along linked brain circuits, «jumping» from neuron to neuron.

Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of plaques (composed of amyloid - beta protein) and fibrous tangles (composed of abnormal tau) in brain cells called neurons.

For example, Gladstone scientists are researching how autophagy — a process by which cells eliminate abnormal proteins — can help to prevent the destruction of brain cells.

Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid - β peptide (Aβ) that is derived from amyloid - β protein precursor (AβPP) by the action of beta - and gamma - secretases.

Abstract: Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid - β peptide (Aβ) that is derived from amyloid - β protein precursor (AβPP) by the action of beta - and gamma - secretases.

A group of disorders that includes both Alzheimer's and FTD, tauopathies are characterized by the abnormal accumulation of the protein Tau in neurons.

By combining pieces of different genes, fusion genes can lead to production of abnormal proteins that disrupt cell function.

Research efforts led by Dr. Elizabeth Lawlor are studying how Ewing sarcoma cancer cells are able to survive when deprived of oxygen, and whether suppression of specific proteins can address this abnormal cell survival and lead to better outcomes for patients.

They're caused by normally harmless proteins that become abnormal and form clumps in the brain.

He took advantage of an observation made by Alfred Goldberg of Harvard Medical School, who had shown that extracts of immature red blood cells require ATP to break down abnormal proteins.

Earlier lab work by the researchers helped explain key mechanisms involved with assisting vitamin D3 to clear the abnormal protein amyloid - beta, which is found within the plaque.

It could be that the nerves in my Dad's heart might be misbehaving because they are abnormal AND because they are being assaulted by stressors resulting from his very standard American diet such as systemic inflammation, calcifications, reduced blood viscosity, reduced nitrous oxide, or any of the other chronic insults to our hearts and vascular system that results when we eat animal proteins, lots of fat, especially saturated fat, and highly processed junk plant foods.

Cachexia is characterized by an ongoing loss of skeletal muscle mass due to abnormal metabolism and protein catabolism, thought mostly to be associated with chronic inflammation.

Abnormal T3 and T4 readings may be caused by too much or too little protein globulin in your body.

Parkinson's is due to degeneration of the brain's dopamine area; parkinsonism is caused primarily by abnormal clumping of proteins called alpha - synuclein.

This autoimmune disease is caused by an abnormal response to gluten, a protein found in grains such as wheat, rye, and barley.

[6] Gliadin proteins have the ability to provoke an autoimmune enteropathy caused by an abnormal immune response in genetically susceptible individuals.

Although there is still a lot to learn about pathogenesis (the mechanism by which a disease is caused) of Alzheimer's yet we know that during Alzheimer's two abnormal proteins are made by mutated genes of the brain cells.

In thyroid cancer in dogs caused by parafocllicular cells can cause diarrhea resulting from the production of abnormal proteins in the C - cells.

These «paraneoplastic syndromes» may be due to abnormal hormone production by the cancer, and may include increased blood calcium levels and increased blood gamma globulin (immune system related protein).