Sentences with phrase «by adjuvants»

Although killed or inactivated products make up about 15 % of the veterinary biologicals used, they have been associated with 85 % of the post-vaccination reactions, mainly because of the acute adverse responses induced by the adjuvants used in companion animal, wildlife and livestock species (Dodds, 1997; Luján et al, 2013).

Coulter believes that brain inflammation is brought on by adjuvants or other antigenic substances in vaccines.

Between April 1993 and March 2003, 1011 patients were randomized to four treatment arms, 252 patients received preoperative radiotherapy alone, 253 patients received preoperative radiotherapy — chemotherapy, 253 patients received preoperative radiotherapy followed by adjuvant chemotherapy, and 253 patients received preoperative radiotherapy and chemotherapy followed by adjuvant chemotherapy.

However, adjuvant chemotherapy did not improve survival or disease - free survival, but we noted that the curves by adjuvant treatment did diverge progressively starting from year four for overall survival and from year two for disease - free survival.

The hypothesis linking adjuvant - induced chronic inflammation to sarcoma formation has been suggested by several authors beginning in the early 1990s.3 - 5 Controversy over the role of adjuvant in sarcoma pathogenesis intensified with the publication of a limited number of studies suggesting there was no significant difference in FISS risk posed by adjuvanted versus nonadjuvanted vaccines.10, 11,19 No studies have been published that suggest an adjuvanted vaccine is safer than a nonadjuvanted vaccine, with respect to FISS risk.

Not exact matches

The two schedules alternating AS03 - and MF59 - adjuvanted formulations led to lower geometric mean (average) titers (GMTs) than the group induced by two AS03 - adjuvanted formulations but higher GMTs than two doses of MF59 - adjuvanted formulation.

This review article appearing in Technology and submitted by researchers from Iowa State University investigates the potential of polymeric adjuvants, both natural and synthetic.

Indeed, the authors point out that Ipilimumab might better effect recurrence - free survival than adjuvant interferon and should be considered as an option by oncologists in this field considering its activity across subgroups including those with high tumor burden.

As reported in 2015, the study met its primary endpoint after a median follow up of 2.3 years, with ipilimumab significantly improving recurrence - free survival.2 The drug was subsequently approved by the US Food and Drug Administration as adjuvant therapy for stage III melanoma.

«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»

This delivery method could also improve the safety of adjuvants, by confining their effects to the lymph nodes.

«Standard first line treatment consists of surgical resection followed by radiation and concomitant and adjuvant temozolomide therapy.

A recent survey among 36 vaccine producers, also presented by Kieny, showed that only 12 of the 33 proposed vaccine formulations will contain an adjuvant.

Boosting the immune response by including adjuvants, and delivering the vaccine under the skin instead of into muscle, could help to lower the dose required and cut costs, as could new kinds of vaccine, he says.

Based on these results, two phase 3 trials are being planned for platinum - sensitive and platinum - resistant ovarian cancer patients by one of NCI's new National Cancer Trial Network Groups, the NRG Oncology Group (formerly 3 cooperative groups: the National Surgical Adjuvant Breast and Bowel Project (NSABP), the Radiation Therapy Oncology Group (RTOG), and the Gynecologic Oncology Group (GOG).

Final results of a randomised phase III study on adjuvant chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group.

Letrozole is approved by the FDA for the adjuvant treatment of early - stage breast cancer in postmenopausal women who have already been treated with 5 years of tamoxifen therapy.

The VFL was established by the World Health Organization in 2010, in order to allow the global vaccine community to gain open access to adjuvant technology and vaccine formulation expertise.

Adjuvants are increasingly used by the vaccine community and are essential components of modern vaccines, particularly for their ability to enhance and bias immune responses and for their dose - sparing properties.

UNIL - VFL provides access to adjuvants that are either not covered by intellectual property rights or are readily negotiable under license agreements, including oil - in - water emulsions, water - in - oil emulsions, aluminium salts, liposome - based adjuvants, TLR agonists, microparticles, saponins, and combination adjuvants.

This will include testing the mechanism of action of different adjuvant and antigen formulations by measuring B - and T - cell responses and by using various functional assays (ELISA, FACS, cytokine profiles), transcriptomics and / or proteomics.

This can be achieved either by a combination of PAMPs working in synergy to activate DCs or through the use of novel adjuvants.

[6] In the MSLT - 1 trial, patients with isolated nodal recurrence had more total lymph nodes involved by melanoma than patients randomized to SLN biopsy who had a positive biopsy (all of whom were to have CLND; an average of 3.2 lymph nodes involved with metastatic melanoma vs only 1.4 positive nodes, respectively; P <.0001), [2] and were more likely to meet established criteria for adjuvant radiation, [7] which further increases the risk of postoperative lymphedema.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

Adjuvants are frequently used by the vaccine research and development community, primarily for their ability to modulate immune responses and improve dose - sparing.

Differential immune responses to HIV - 1 envelope protein induced by liposomal adjuvant formulations containing monophosphoryl lipid A with or without QS21.

Melanoma is a tumor that is recognized by the immunological system and mechanisms leading to an anti-tumor immune response of potential value in the adjuvant setting.

That combination in the adjuvant setting still awaits an approval by the FDA.

We were thus able to conclude that age - related cognitive decline is accentuated by chemotherapy, providing basis for questioning the place of adjuvant chemotherapy in this elderly patient population.

They seek to improve and prolong the level of protection seen in RV144 by using an extra vaccine boost and different adjuvants that may increase and prolong antibody responses.

These were then formulated into experimental vaccines by conjugation to keyhole limpet hemocyanin as a carrier peptide and aluminum hydroxide as an adjuvant.

These demonstrated that both primary CD4 and CD8 T cell responses and development of memory to protein antigen in adjuvants (e.g. CFA, alum), or to several viruses, or to a range of tumors are strongly controlled by OX40.

Adjuvant - this is given to boost the immune response, for example by presenting the antigen in a certain way

Previous options in adjuvant therapy were «controversial, to say the least,» she noted, since they were limited by efficacy and concerns about toxicity.

The results obtained by this service may be part of the documentation provided to other analytical services (TNA3), Adjuvants and delivery systems (TNA2) or Immunogenicity and efficacy studies (TNA8) as well as the Pre-clinical GLP production services (TNA4) and the GMP production services (TNA5).

Once recombinant vaccine antigens produced by this service are available, they could be forwarded to Analytical services (TNA3), Adjuvants and delivery systems (TNA2) or Immunogenicity and efficacy studies (TNA8), if applicable.

A team of U.S. government researchers led by scientists from the Walter Reed Institute of Research (WRAIR) created a dual vaccine formulated with three main components: a segment of a protein expressed on the surface of HIV; a synthetic molecule that resembles heroin and its degradation products; and a potent adjuvant to stimulate the immune system.

Chaired by Prof. Dirk Schadendorf, talks covered topics which included: melanoma epidemiology in the in period since the start of the German National Skin Cancer screening programme (Dr Andreas Strang); an overview of melanoma therapies used in stage IV melanoma; adjuvant therapies and prognosis in stage III melanoma (Dr Lisa Zimmer); tumour heterogeneity, plasticity and resistance in melanoma (Alexander Roesch); epigenomics of normal and abnormal cell differentiation (Bernard Horsthermeke); and, genetics and epigenetics of uveal melanoma (Michael Zeschnigk).

A 2015 article in the International Journal of Biochemistry and Cell Biology sums up the findings of multiple studies on ketogenic diets and cancer with the following: «there is increasing evidence that the ketogenic diet may also be beneficial as an adjuvant cancer therapy by potentiating the antitumor effect of chemotherapy and radiation treatment.»

We induced local inflammation in juvenile and adult rats that had been fed a 6.6:1 ketogenic diet for three weeks.22 Inflammation was produced by subcutaneous injection of complete Freund's adjuvant into one hindpaw.

Westall, F.C. (2007) Abnormal hormonal control of gut hydrolytic enzymes causes autoimmune attack on the CNS by production of immune - mimic and adjuvant molecules: a comprehensive explanation for the induction of multiple sclerosis.

The IL -6-aluminum adjuvant connection was found in study [Alawdi et al 2016] where scientists were using aluminum to induce Alzheimer's in rats, «The results also showed that aluminum administration increased the hippocampus pro-inflammatory cytokines TNF - α by 3.8-fold, IL - 6 by 4-fold, and iNOS by 3.8-fold compared to the normal control group.»

These happen when your pup's immune system is confused by the viruses and adjuvants which have been injected and instead of attacking the virus it attacks it's own healthy cells.

Adjuvants are known to cause local reactions characterized by inflammation, granulomas and, occasionally, sterile abscess formation.18 Currently, all inactivated (killed) feline vaccines sold in the U.S. and Canada are adjuvanted.

Instead, it could be a sign that the viral or bacterial component, or the adjuvant (which, containing foreign protein, is seen as an invader by the immune system), in the vaccine is winning by stealth.

It is interesting to note that while The American Association of Feline Practitioners guidelines contains the weakest language in regards to adjuvanted versus non-adjuvanted vaccines, that panel also was financially sponsored by, wait for it....

For cats, there is a safer vaccine: Purevax, by Merial, is a recombinant vector vaccine that does not induce the inflammation that occurs with killed, adjuvanted vaccines.

Not all vaccines have adjuvants in them, and by choosing to use non-adjuvanted vaccines, the risk of vaccine - associated sarcomas is greatly reduced.

The appellant, however, has withdrawn its claim for patent on those and seeks instead a patent on compositions formed by mixing them with appropriate adjuvants.