Sentences with phrase «by aggregating proteins»

Huntington's disease, for example, is caused by aggregating proteins inside brain neurons that ultimately lead to motor dysfunction, personality changes, depression and dementia, usually progressing rapidly after onset in people's 40s.

«The assumption has been that the disease is caused by the aggregated proteins,» Workman says.

Not exact matches

Taken together, the results suggest that gut microbes exacerbate motor symptoms by creating an environment that could favor the accumulation of misfolded protein aggregates.

«We were able to show that the formation of aggregates is promoted by defects in the protein blueprint and these are not detected by the internal quality control machinery,» explains Young - Jun Choe, first author of the study together with Sae - Hun Park.

Next, the researchers gave the non-protected zebrafish an investigational drug, CLRO1, being developed by UCLA scientists that breaks up the protein aggregates, or clumps, in Parkinson's patients.

Isotope labeling ruled out the possibility that aggregated proteins were being degraded and replaced by new proteins, which would be unlabeled.

The Max Planck scientists could also show that a toxic protein related to the abnormal, aggregate - forming protein «huntingtin» of patients with the neurodegenerative Huntington's disease is efficiently destroyed by the newly identified pathway.

Indeed, infectious prions are solely composed of preformed aggregates of misfolded prion protein, which transmit disease by seeding the aggregation of the endogenous prion protein, resulting in the accumulation of large quantities of these toxic aggregates in the brain (Prusiner, 1998; Soto et al., 2006).

A series of exciting recent studies suggested that the process of protein misfolding and aggregation implicated in various PMDs can be transmitted by administration of preformed, misfolded protein aggregates, in a way reminiscent of the transmission of prion diseases by infectious prions (Prusiner, 2012; Soto, 2012; Jucker and Walker, 2013).

This is a subject of great importance, because, in most previous studies, the transmission of the pathologic misfolded aggregates did not induce the disease phenotype, raising a debate about whether seeding of protein misfolding is equivalent to disease transmission by infectious proteinaceous agents (Guest et al., 2011; Schmidt et al., 2012; Fernández - Borges et al., 2013; Piccardo et al., 2013; Walsh and Selkoe, 2016).

They fold into a particular structure, aggregate and then propagate by attracting more proteins into that structure.

AEC syndrome caused by pathological protein aggregates / Research lays groundwork for causal therapies.

The researchers used CRISPR / Cas9 gene editing, delivered by a viral vector, to snip part of a gene producing toxic protein aggregates in the brains of 9 - month old mice.

We hypothesize that these aggregating proteins also block the transport of normally transported axonal proteins, and thus cause neurodegeneration and neuronal death by impairing axonal transport.

Total crosslinks, total protein carbonyls, total AGEs, total amyloid, aggregate, adducts, mtDNA oxidative lesions, total lipofuscin, total oxidized redox disulfides, total lipid peroxidation chain propagation by aldehydes and propagators (MDA Malondialdehyde / TBARS, 4 - HNE, Acrolein), total giant senescent mitochondria and a crap load of others.

«Parvalbumin collects up the «Parkinson's protein» and actually prevents it from aggregating, simply by aggregating itself first,» explains Pernilla Wittung - Stafshede, Professor and Head of the Chemical Biology division at Chalmers, and lead author on the study.

Miguel Coelho (Tolić - Nørrelykke, MPG)-- «Ageing by passive aggregation and stochastic distribution of protein aggregates» (2012)

Four of the mAbs, 2T5C9, 2G9C, T1F11, and TB2H7, demonstrated diagnostic potential in enzyme - linked immunosorbent assays (ELISA) by their low to sub-nanomolar cross-reactivity with recombinant wild - type (WT) and mutant TTR aggregates and lack of binding to native TTR or amyloid fibrils formed by other peptides or proteins.

To address this, we have generated 22 monoclonal antibodies (mAbs) against aggregates formed by a blood transport protein, transthyretin (TTR), which primarily forms amyloid fibrils in a patient's heart and / or peripheral nerves.

Autophagy (more specifically macroautophagy) is the process by which cellular compartments, such as membranes and organelles and also protein aggregates, are recycled back into their building blocks [122].

Following aggregate plating and Ara - C addition, Oct4 protein expression progressively decreased, disappearing by day twelve.

Meanwhile, computational modeling of the effect of the phosphorylation in the structure of the protein, led by co-author Jeetain Mittal at Lehigh, showed that the change in electric charge is what led to the difference in the proteins» likelihood of aggregating.

Analysis of Oct4 protein expression in differentiated Ara - C cultures (DACs) showed a slight increase of Oct4 protein by day four of aggregate formation (Figure 1C), consistent with previous reports examining Oct4 mRNA dynamics [22] and the finding that primitive endoderm differentiation is accompanied by a transient increase in Oct4 protein levels [23].

A comparison of the absorption and corrected excitation spectra of the Amrose proteins suggests the presence of a certain amount of non-emissive dimers or aggregates as shown in Figure 3 exemplarily for Amrose v1, indicated by the mismatch of the signals on their short wavelength side.

On the one hand, autophagy functions as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins.

When brain tissue from mice affected by Alzheimer's was with treated with vitamin C, the toxic protein aggregates had been dissolved.

«Cells respond to different types of stress by inhibition of protein synthesis and subsequent assembly of stress granules (SGs), cytoplasmic aggregates that contain stalled translation preinitiation complexes.

Aggregate effects on IGF and its BPs were estimated by multivariate regression on macronutrient sources from dietary questionares and blood samples in 4700 + subjects, but the effect sizes were small and the only protein source where a statistically significant effect was seen was with dairy protein and dietary calcium (ie associated with dairy in general population cohorts).

The crystallins, which make up over 90 % of the proteins in the lens, are specially adapted to contribute to the maintenance of transparency by forming soluble, high - molecular weight aggregates that need to stay in solution for the duration of an individual's life.