Sentences with phrase «by agonists»

All three antagonists significantly reduced the proportion of the cells that were excited by the agonists.

Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth - hormone - releasing hormone.

Schubert U, Schmid J, Lehmann S, Zhang XY, Morawietz H, Block NL, Kanczkowski W, Schally AV, Bornstein SR, Ludwig B. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth - hormone - releasing hormone.

Using the strict definition, voluntary activation refers to the percentage of involuntary force production that can be exerted by an agonist muscle group, most commonly using the interpolated twitch technique (Shield & Zhou, 2004).

Not exact matches

My central claim in the book is that the «ontological turn'taken by a number of thinkers of radical or agonist democracy, in the belief that reflecting on the essential dynamics of political being would engender a revivified understanding of possibilities for democratic action, created a particularly influential strand of socially weightless theorising.

This is particularly true in the case of synthetic cannabinoids receptor agonists, known by one of their popular brand names of Spice.

A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of β - arrestin 2 with Smo.

Ozanimod blocks sources of inflammation in RMS by acting as a sphingosine 1 - phosphate 1 (S1PR1) receptor agonist.

Bohn noted isoquinolinone 2.1 is one example of a new class of «biased» kappa agonists that avoid many central nervous system side effects by preferentially activating a G protein - mediated signaling cascade without involving another system based on β - arrestin protein interactions.

Borrowing the term for a compound that boosts the effect of a neurotransmitter, he speculates that peyote serves as a «humility agonist,» counteracting his arrogance by instilling awe and reverence in him.

The researchers showed that a two - day treatment regimen with partial or selective PPAR - γ agonists (Telmisartan and Rosiglitazone — both FDA - approved drugs) ameliorated the pathological outcomes of infection in mice by inducing expression of glucose transporters.

One of the most recent new medications for the treatment of alcohol dependence is the GABA - B agonist Baclofen, which has shown mixed results which may be explained by this work.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

The whole - cell current response to glutamate and kainate [a non-NMDA (N - methyl - D - aspartate) receptor agonist] was enhanced by forskolin, an activator of adenylate cyclase.

By the time patients are diagnosed with it, they have most likely already tried drugs known as beta - agonists that relax the airways to ease breathing, with disappointing results.

TZDs and other PPAR - γ agonists suppress macrophage production of TNF - α, IL - 6, NO, and IL - 1β induced by LPS and IFN - γ (87 — 90).

The researchers demonstrated the method by using it to find a potent antibody mimic, or «agonist,» of erythropoietin (EPO), a hormone that stimulates the production of red blood cells.

As an alternative test for receptor specificity, we applied the 5 - HT3 receptor agonist CPG, which induced an increase in intracellular calcium in 5 - HT3AGFP cells; the agonistic effect was blocked by ODS (n = 5, t (4) = 20.55, p < 0.0001 paired Student's t test; Fig. 4D, H).

Interestingly, unlike the unpolarized cytokine response observed upon stimulation with TCR agonists, Vα14 iNKT cells activated by this indirect, TLR / IL -12-dependent pathway secrete only IFNγ in significant quantities.

UNIL - VFL provides access to adjuvants that are either not covered by intellectual property rights or are readily negotiable under license agreements, including oil - in - water emulsions, water - in - oil emulsions, aluminium salts, liposome - based adjuvants, TLR agonists, microparticles, saponins, and combination adjuvants.

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

Yachi, P.P., Lotz, C., Ampudia, J. & Gascoigne, N.R.J. T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state.

Kehr, J.; Hu, X.J.; Yoshitake, T.; Scheller, D. Determination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection.

The functions of Growth Hormone Secretagogue Receptor (GHS - R) were formerly assessed by studies carried out with synthetic peptidyl agonists.

The lab's findings in the study, «D - serine Deficiency Attenuates the Behavioral and Cellular Effects Induced by the Hallucinogenic 5 - HT2A Receptor Agonist DOI,» suggested that D - serine - dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5 - HT2AR activation.

Mechanism of AMPA Receptor Activation by Partial Agonists.

Differential control of T < sub > H 1 versus T < sub > H 2 cell responses by the combination of low - dose steroids with β < sub > 2 - adrenergic agonists.

He previously showed that in comparison to white children, a higher percentage of minority children are not helped by inhaled asthma rescue medicines, called beta - agonists, used to rapidly re-open airways during asthma episodes.

EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells

The citation for the paper is Regulation of circadian behaviour and metabolism by synthetic REV - ERB agonists.

Agonist reagents that stimulate OX40 also have great potential therapeutically for vaccination, as shown by a number of studies in tumor models or of responses to viruses where the immune response can be boosted dramatically to aid protection.

Due to the serious side effects caused by the activation of the pharmacologically and structurally closely related subtypes, it is essential that 5 - HT2C agonists developed for clinical use have a high specificity and subtype selectivity.

«We are excited to be a part of this important new initiative to develop novel treatment options for patients,» said Ovid Trifan, M.D., Ph.D., chief medical officer of Apexigen, Inc. «APX005M is a potential best - in - class CD40 agonist that works by activating the immune system's antigen - presenting cells in the tumor microenvironment.

In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca (2 +) channels in a constitutive, as well as agonist - dependent manner (By similarity).

(A) Peptides targeting the Eph receptors can function as antagonists that inhibit ephrin binding and receptor signaling, or in some cases as agonists that mimic the ephrins by activating Eph receptor signaling.

For LTßR agonist treatment, mice were treated with agonistic anti-LTβR antibody (3C8, provided by Carl F Ware) by i.p. injection of 100 μg of antibody every 3 days for 6 days.

Opposite muscles workout — Build Muscle and Strength by Working the Agonists and Antagonists in One Workout

Why: Supersetting agonist and antagonist muscle groups is not only time efficient and great for building lean, toned arms, but it also increases the afterburn effect of your workout by up to 24 hours.

What you may have heard: Long - acting bronchodilators may increase the risk of asthma - related death Long - acting beta2 - agonists, a type of bronchodilator, open the airways in the lungs by relaxing the muscles that line the airways.

Such differences might be reflected in differences in agonist activation (measured by electromyography) and voluntary activation, and the sources of the differences could occur at either the spinal or cortical levels.

CB2 cannabinoid agonists such as WIN55,212 - 2 inhibit experimental autoimmune encephalomyelitis (EAE), an animal model of MS, by mediating apoptosis of the encephalitogenic cells that induce brain inflammation (41).

Water resistance and movement impact on both agonist and antagonist muscles and generate a natural massage that clearly improves the skin aspects and cellulite by draining the entire lymphatic system.

Indeed, this is underscore by the fact that some carefully controlled studies have reported that substantial early phase strength gains occur in as little as 5 days without changes in agonist muscle activation as measured by EMG amplitudes (Holtermann et al. 2005).

This very important study is one of the very few that have actually tested the idea, by assessing the effects of just 5 days of training in untrained subjects on strength gains and on agonist, synergist, and antagonist activation levels.

As explained above, agonist muscle forces (as indicated by the proxy of EMG) are probably largely similar when lifting the same relative load (but a different absolute load) under stable and unstable conditions.

Butorphanol tartrate, also known as Torbutrol ® is an opiate agonist used by veterinarians primarily as an anti-tussive, to help alleviate coughing.

Alpha - 2 Agonists: work by decreasing nervous system sensitivity in area, referred to as thiazine.