Sentences with phrase «by alpha cells»

Glucagon by the Alpha Cells which is responsible for the conversion of glycogen to glucose

Glucagon is synthesized by alpha cells of pancreas.

produced by the alpha cells of the pancreas 2.

Blood glucose levels are regulated by the pancreas» beta cells, which secrete insulin that signals to the body to reduce blood glucose levels; and by alpha cells, which secrete glucagon that signals to the body to increase blood glucose levels.

Cannabinoids produced by the alpha cells may in fact activate cannabinoid CB1 receptors located in the pancreatic islets.

Not exact matches

The research team also found that the action of a gene, ATG16L1, kept TNF alpha - driven inflammation from triggering the self - destruction of too many Paneth cells, by an explosive process called necroptosis.

«Our study results are the first to argue that we may be able to treat inflammatory bowel disease and protect against transplant rejection not only by blocking TNF alpha as is done currently, but also by stimulating ATG16L1 to prevent early death of cells lining the gut,» says study senior investigator Ken Cadwell, PhD, an associate professor at NYU School of Medicine and NYU Langone Health's Skirball Institute for Biomolecular Medicine.

When Candida albicans cells reproduce by mating, they have two sex types, «a» and «alpha».

So alpha - lac may induce apoptosis by directly causing the destruction of DNA from within the cell's nucleus, or it may instigate the suicide - generating caspace cascade through the mitochondria.

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

For decades, experts thought the alpha particles released by radon didn't affect the cell's cytoplasm.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

Using cell cultures, the research team also found two ways to prevent the toxicity caused by alpha - synuclein: gene therapy that forced the neurons to make more TOM20 protein protected them from the alpha - synuclein; and a protein that was able to prevent alpha - synuclein from sticking to TOM20 prevented alpha - synuclein's harmful effects on mitochondria.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

Scientists from the Nencki Institute of Experimental Biology of the Polish Academy of Sciences in Warsaw have recently discovered that the alpha and beta cells communicate with each other, and the central role in this communication is played by cannabinoids — organic compounds that occur in nature also in inflorescences of cannabis.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

By comparing the gene expression patterns of normal beta cells and insulin - producing cells derived from alpha cells, the researchers confirmed nearly complete cellular reprogramming.

Croft believes the heightened alpha waves reflect the mind concentrating to overcome the electrical interference in brain circuits caused by the pulsed microwave radiation from cell phones.

Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying alpha - amino -3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)- selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7 - dinitroquinoxaline -2,3-dione (CNQX).

The patients without diabetes produced autoantibodies that completely impaired the activity of a subtype of interferon known as interferon - alpha, which is produced by the immune cells and may cause inflammation.

In another set of experiments, the researchers found that fetal dendritic cells could block the production of TNF - alpha by adult T cells as well.

Targeting IFN - alpha to B cell lymphoma by a tumor - specific antibody elicits potent antitumor activities.

Antonio Lanzavecchia finds that efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte / macrophage colony - stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self - tolerance maintained by activated T cells expressing IL - 2 receptor alpha - chains (CD25).

Cytokine expression by human marrow - derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL - 1 alpha.

Isoform - Specific PKA Dynamics Revealed by Dye - Triggered Aggregation and DAKAP1 [alpha]- Mediated Localization in Living Cells.

AGEs impair this axonal transport and alpha adrenergic blockers (acting on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look on the molecular mechanisms of this process (crosslinking of motor proteins in axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.

Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.

Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.

There are now multiple immunotherapies targeting clearance of alpha - synuclein from the brain in early - stage clinical trials, and multiple trials underway or in the works on the next generation of cell replacement therapies for dopaminergic neurons, including the TRANSEURO trial; the Summit4StemCell initiative, put together by Jeanne Loring — a researcher at The Scripps Research Institute who is exceptionally engaged with turning her research into therapies; a Japanese trial to be run by Jun Takahashi of Kyoto University in Japan (cf. here and here); and a trial centered at Memorial Sloan Kettering Cancer Center headed by cell biologist Lorenz Studer.

The expression of TNF - alpha, NF - κB in acinar cells and macrophage CD11b was measured by FACS.

Alpha tubulin is not suitable as a loading control in adipose tissue as expression of tubulin in adipose tissue is very low (Spiegelman and Farmer, Cell, 1982, 29 (1): 53 - 60, «in cells undergoing adipose differentiation actin synthesis decreases by 90 %»).

Ab7291 staining alpha tubulin in human breast cancer cell line by ICC / IF (Immunocytochemistry / Immunofluorescence).

The cells were then incubated with ab7291 at a working concentration of 0.5 μg / ml and ab190573, Rabbit monoclonal [EP1332Y] to alpha Tubulin (Alexa Fluor ® 647, shown in red) at 1/250 overnight at +4 °C, followed by a further incubation at room temperature for 1h with an anti-mouse AlexaFluor ® 488 (ab150117) at 2 μg / ml (shown in green).

Kraman, M. and Bambrough, P. J. and Arnold, J. N. and Roberts, E. W. and Magiera, L. and Jones, J. O. and Gopinathan, A. and Tuveson, D. A. and Fearon, D. T. (2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein - alpha.

The pre-clinical study results show that the synthesized steroid, squalamine, prevents and eliminates alpha - synuclein build - up inside neurons by unsticking the protein from the inner wall of nerve cells, where it clings and clusters into toxic clumps, researchers say.

Studies of two T cell types that are equally activated by alpha - fetoprotein, a...

(A) iPS cells can form embryoid bodies (EB) and can differentiate in vitro to endoderm shown by alpha fetoprotein (AFP)(B), mesoderm shown by smooth muscle actin (SMA) and desmin (D, E), and ectoderm shown by GFAP and SMI31 staining (G, H).

Differentiated mouse Th1 cells (A, B, C) and naïve mouse CD4 cells (D, E, F) were analyzed by flow cytometry for (A, D) T - bet expression using Human T - bet / TBX21 Alexa Fluor ® 488 - conjugated Antibody (Catalog # IC53851G), (B, E) TNF - alpha expression using Mouse TNF - alpha PE - conjugated Antibody (Catalog # IC410P), and (C, F) IL - 18R alpha expression using Mouse IL - 18 R alpha / IL - 1 R5 APC - conjugated Antibody (Catalog # FAB1216A).

ab1 at 1/200 dilution staining HIF - 1 alpha in human 293FT cells by Immunocytochemistry / Immunofluorescence.

2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by alpha interferon (IFN - alpha).

Oregon Health and Science University, «Determine the role of alpha cell heterogeneity in T1D,» led by Dr. Markus Grompe

A therapy that could reestablish alpha cells» ability to detect low glucose levels and secrete glucagon would be a game - changer for glucose management, by reducing or even preventing hypoglycemic episodes.

University of Miami, «Pilot studies to understand alpha cell dysfunction and correct glucagon secretion in type 1 diabetes,» led by Dr. Alejandro Caicedo

Vanderbilt University, «Improving isolation of pancreatic islets in T1D to assess alpha cell function and gene expression,» led by Drs. Al Powers and David Harlan (University of Massachusetts Medical School)

Two IFN - alpha - unresponsive mutants were isolated previously at a low frequency (ca. 10 -LRB--8)-RRB- by selecting mutagenized 2fTGH cells in selective medium containing 6 - thioguanine and IFN - alpha.

University of Dundee, «Understanding the hypoglycemia - specific defect in alpha - cell glucagon secretion using a humanized mouse model of T1D,» led by Dr. Rory McCrimmon

The new study found that T cells can be tricked into thinking dopamine neurons are foreign by the buildup of damaged alpha - synuclein proteins, a key feature of Parkinson's disease.

Studies show that yohimbine can accelerate fat loss by blocking the activity of alpha - receptors in fat cells.