Sentences with phrase «by altering cell»

The nibs are a great source or antioxidants called flavonoids, which help boost our health by altering cell - signaling pathways.

Not exact matches

Then, the DNA would be removed from an oocyte (an egg cell) and this enucleated oocyte fused to the altered adult cell» creating a new cell that is neither an oocyte nor an adult cell but a hybrid exhibiting the properties programmed into it by the alterations made to the adult - cell nucleus.

In both cases individual members may exercise some dominance over others, in particular by altering the patterns guiding further growth and development, but the social coordination stems from basic patterns embodied in the genetic makeup of the plant cells and in the laws and traditions of human culture.

Also, it is well - known that body cells alter their extracellular environment by exchanging chemicals, generating heat, and so on.8

We're surrounded by so much processed food that our cells are no longer capable of recognizing the food we eat because it has been altered and genetically modified.

Martin Fussenegger of the Swiss Federal Institute of Technology in Zurich and his colleagues made this implant by genetically altering human skin cells so that they would become darker in colour when exposed to rising calcium levels.

Altering DNA in germline cells — embryos, eggs, and sperm, or cells that give rise to them — may be used to cure genetic diseases for future generations, provided it is done only to correct disease or disability, not to enhance people's health or abilities, a report issued February 14 by the National Academies of Sciences and Medicine recommends.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Researchers found that NAD +, a natural molecule found in living cells, plants and food protects against autoimmune diseases by altering the immune response and turning «destructive» cells into «protective» cells.

Baby Layla's medical team treated her with immune cells altered by one type of the molecular surgical instruments called TALENs.

It is emerging that the chemical structure of RNA molecules is extensively modified by specific enzymes normally present in our cells, which are commonly found to be altered in severe medical syndromes and various types of cancers.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

The drug lowers blood pressure by altering the flow of calcium molecules in and out of cells.

Now research in rodents suggests that gut microbes may alter the inventory of microRNAs — molecules that help keep cells in working order by managing protein production — in brain regions involved in controlling anxiety.

They developed a computer model that better simulates how the cells recruit new ligands that eventually form focal adhesions by altering the geometry of the matrix's component fibers.

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

Outside of the brain, cytokines are released by immune cells fighting infections, and they can alter MHCI expression in a complicated feedback loop.

The properties of water are altered by near - infrared light, which could drive the energy - producing mitochondria in our cells to work harder and heal us faster

Vitamin A and vitamin D are precursors to hormones that influence biological processes by entering the nucleus of a cell, binding to DNA, and altering the transcription of certain genes.

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

That's the hope of a team led by Yuet Kan of the University of California, San Francisco — and they have proved the principle, altering the genome of induced pluripotent stem cells (iPSCs) to give them a natural mutation that allows some people to resist HIV.

Proponents of this idea suggested that chlorine exposure might destroy the cell wall — by altering it physically, chemically and biochemically — and so terminate the cell's vital functions, killing the microorganism.

That's the hope of researchers led by Yuet Kan of the University of California, San Francisco — and they have proved the basic principle, altering the genome of induced pluripotent stem cells (iPSCs) to give them a rare natural mutation that allows some people to resist HIV.

Epigenetic changes do not alter the information encoded in the DNA sequence itself but determine whether and to what extent specific genes are used by cells.

* No sperm necessary: By combining genetically altered cells, Japanese scientists create a healthy baby mouse using only female DNA.

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

Studies in diabetic rodents suggest that diabetes may alter the intestine's mucosal lining, which is maintained and regenerated by intestinal stem cells; however, little is known about how this occurs and whether it is relevant to humans.

There are about as many microbial cells in our body as our own cells, and they appear to be transmitted from mother to child during birth and continually altered by the home environment, type of diet, medications and even the family pet.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

ONC201 may inhibit cancer stem cell self - renewals by altering their gene expression, according to a study published August 2, 2017 in the open - access journal PLOS ONE by Varun Vijay Prabhu from Oncoceutics, Inc., USA and colleagues.

Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition by host immune cells, could end up destroying the structural integrity of the entire shell.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

«By combining in vivo multiphoton microscopy and in vivo electrophysiology, our lab is better able to visualize how cells move and change over time in the living brain and explain how changes in these glial cells alter the visually evoked neural network activity,» says Kozai.

By shining pulses of light on the altered cells, scientists can switch them «on» or «off,» resulting in the same flow of ions that occurs when neurons fire naturally in the brain.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

In addition, the analysis provided some hints about how chemotaxis evolved from a simple signaling network that responds slowly to environmental cues — primarily by turning on genes — to a multiprotein system that can quickly alter a cell's course.

Using a high - powered microscope, the UCLA researchers observed that bacteria cells lost some of the structure and definition of their outer membranes, which indicated that resveratrol may work by altering and possibly weakening the structure of the bacteria.

Its presence influences the behaviour of nanoparticles in the body by altering their chemical properties, destination, and their interactions with other cells.

His blood was drawn and his CD4 cells were filtered out, frozen, and transported to a laboratory where they were genetically altered to resist invasion by HIV.

Whereas place cells in a rat brain may change their firing rates if their environment is altered even a little — for example by changing the colour of the walls — those of grid cells remain robustly unchanged.

Instead, regulation is achieved by cell surface modulation events that alter N - CAM affinity, prevalence, mobility, and distribution on the surface.

The team also demonstrated the utility of the platform by applying it to examine a growth - modulating feedback circuit whose dynamics is qualitatively altered by circuit - host couplings and revealing the behaviors of a toggle switch across scales from single - cell dynamics to population structure and to spatial ecology.

Lin began by studying substances that are able to alter or stop cell division, called inhibitors.

But embryonic clones, the source of an endless supply of stem cells imprinted with one's personal DNA, could alter the equation in favor of the patient and augur a paradigm shift in medicine on par with the changes brought about by antibiotics and vaccines.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

«Now that we can recognize cells altered by APOBEC3, we could teach tumor neoantigen - based immunotherapies to recognize these cells as well,» Pyeon says.

Researchers in Brazil have found that mouse skin responds to caloric restriction by stimulating fur growth, increasing blood flow, and altering cell metabolism to increase energy efficiency.

If so, it may be possible to improve transplant outcomes by altering diets and developing therapies that target the specific cells altered by this condition,» said Iacomini.

By swapping out just one microRNA building block for another, ADAR1 alters the carefully orchestrated system cells use to control which genes are turned on or off at which times.