Sentences with phrase «by altering the expression»

For the first time, scientists have improved how a crop uses water by 25 percent without compromising yield by altering the expression of one gene that is found in all plants, as reported in Nature Communications.

IL - 6 can induce osteoclast activation indirectly by altering the expression of RANKL and OPG in osteoblasts (51).

Not exact matches

Our understanding of sex in the narrower sense of genital activity and in the wider sense of relationship with others has been so altered in recent years that the assumed fixity of thought in this area, with reference to auto - erotism, homo - erotism, and hetero - erotism, along with the related fixity which has been traditionally accepted in respect to judgements upon the right or wrong ways of sexual expression, has been shown to be indefensible by any intelligent standards.

Merleau - Ponty helps us to see the links between feeling, meaning, and expression; by implication he alters our understanding of symbolic truth.

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

Outside of the brain, cytokines are released by immune cells fighting infections, and they can alter MHCI expression in a complicated feedback loop.

Those studied by Dunlop are her colleagues alter their traits — protein expression, for instance — but not their genomes, making them significantly more difficult to identify since the resistance level of each bacterium changes over time.

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

ONC201 may inhibit cancer stem cell self - renewals by altering their gene expression, according to a study published August 2, 2017 in the open - access journal PLOS ONE by Varun Vijay Prabhu from Oncoceutics, Inc., USA and colleagues.

The article «A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring» by Sanchez - Hernandez et al. was published in the journal Applied Physiology, Nutrition, and Metabolism.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

By comparing gene expression in the lungs of ducks infected with either highly or weakly pathogenic avian influenza H5N1 viruses, the team identified genes whose expression patterns were altered in response to avian influenza viruses.

Rare variations, by contrast, are more likely to alter protein expression or function and therefore have a direct or causal association with a disease.

In telomeric DNA mutants of Tetrahymena thermophila, created by expression of a telomerase RNA with an altered template sequence, division of the germline nucleus was severely delayed or blocked in anaphase.

The researchers showed these relationships between ecRNA production and gene activity in neurons included genes whose expression is altered by neuronal activity and genes implicated in developmental and neurodegenerative disorders.

The team analysed the sperm of the offspring from the undernourished mothers to see how many genes had had their expression altered by the addition or removal of a methyl group — an epigenetic change.

I am currently exploring functions of BIN1 by generating mouse models to modify the levels of BIN1 expression in the brain, and investigating how altering the levels of this protein can modify AD - related pathophysiology.

This mechanism allows dendritic cells to respond to altered lipid homeostasis by changing gene expression and immunophenotype.

«Altered microenvironment promotes progression of pre-invasive breast cancer: myoepithelial expression of integrin DCIS identifies high - risk patients and predicts recurrence» by Michael D Allen et al. published in Clinical Cancer Research on Tuesday 3 December.

The epigenome functions like a set of switches for regulating gene expression and can be altered by environmental conditions.

These studies are unable to determine a causal relationship due to factors such as gene regulation — a genetic variant may instead contribute to altered expression levels of true causal genes, which remain undetected by a GWAS.

The researchers also showed just how flexible their LITE system could be by applying it to altering gene expression via epigenetics with the addition of histone modifiers.

But transcriptome studies also have significant limitations, such an inability to determine reverse causality — whether gene expression levels are altered by disease, or whether disease arises due to altered gene expression.

HLA expression altered by AVV - mediated genome editing.

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.

These GEMM - ESCs, with often multiple modified alleles, form the basis for further genetic engineering either by Flp - recombinase mediated integration, gene targeting or Crispr / Cas9 to allow for the evaluation of altered target gene expression in a spontaneous tumor model.

To identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.

Using genomics approaches, Dr. Nobrega has identified the gene IRX3 as the strongest association to polygenic obesity in humans, and characterized the mechanisms by which mutations altering the expression of a gene called TCF7L2 also represent the strongest genetic link to type 2 diabetes in humans.

We first sought to gain insight into the biological processes that may be altered by elevated miR - 181a expression in the mDA neurons in PD [13].

Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics.

It is also noted that p63 isoform expression is altered during cellular senescence and that the transcription of ΔNp63 is repressed by p53 [41].

These features were related to a modified gene expression pattern in adult male testes, showing an altered gene expression in genes involved in DNA repair and apoptosis that was confirmed by TUNEL assay.

Results: Within 4 h, activation of CD4 (+) T cells invokes changes in histone modifications and enhancer RNA transcription that correspond to altered expression of the interacting genes identified by promoter capture Hi - C.

In a 2016 study in the journal Pediatrics, transgender children who socially transitioned (meaning they have changed their gender expression, choosing to go by a different name and pronouns and possibly also altering their clothing and hairstyle) and felt supported in their identities had normal levels of depression and only slightly elevated levels of anxiety compared to kids whose gender identity corresponded to their birth sex.

In the book Relaxation Revolution: The Science and Genetics of Mind Body Healing, author Herbert (Benson) discusses how breathing can literally change the expression of genes, and that by using your breath, you can alter the basic activity of your cells with your brain.

Mice treated with Lactobacillus rhamnosus, a probiotic with anti-inflammatory properties, exhibited altered GABA receptor expression in the brain accompanied by reduced anxiety - and depressive - like behaviors.»

The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.

Research suggests that exposure to excessive amounts of male hormones (androgens) by the developing fetus may alter proper gene expression.

In other words, even if one is genetically predisposed to diabetes or cardiovascular disease or even cancer, the risks of these can still be minimized by using this diet to alter your genetic expression towards increasing repair.

Sulforaphane is a potent antioxidant which has been found to boost the detoxification activity of liver enzymes by altering genetic expression.

For example, fiber is metabolized by our gut flora into short - chain fatty acids, which bind to and activate receptors on the surface of our cells that alter our metabolism, for example, activating receptors on fat cells to increase the expression of the weight - reducing hormone, leptin.

By adding to, eliminating and / or otherwise altering the figure of a once - identifiable object, Lipton transformed his original model into an expression of the common anguish and uncertainty of his time.

Since to me (and many scientists, although some wanted a lot more corroborative evidence, which they've also gotten) it makes absolutely no sense to presume that the earth would just go about its merry way and keep the climate nice and relatively stable for us (though this rare actual climate scientist pseudo skeptic seems to think it would, based upon some non scientific belief — see second half of this piece), when the earth changes climate easily as it is, climate is ultimately an expression of energy, it is stabilized (right now) by the oceans and ice sheets, and increasing the number of long term thermal radiation / heat energy absorbing and re radiating molecules to levels not seen on earth in several million years would add an enormous influx of energy to the lower atmosphere earth system, which would mildly warm the air and increasingly transfer energy to the earth over time, which in turn would start to alter those stabilizing systems (and which, with increasing ocean energy retention and accelerating polar ice sheet melting at both ends of the globe, is exactly what we've been seeing) and start to reinforce the same process until a new stases would be reached well after the atmospheric levels of ghg has stabilized.

Lausanne, Switzerland About Blog Epigenomics and Epigenetics queries the developmental origins of health and disease by cataloguing the sets of physical markings on chromatin that collaborate to stably alter gene expression.