Sentences with phrase «by aneuploidy»

Phenotypic diversity is caused by this aneuploidy, as loss of the aneuploid chromosomes restored both euploidy and the wild - type parental phenotype.

«This suggests that the aneuploidy state itself could create variability, and that could provide an additional explanation of why diseases that are caused by aneuploidy are so variable,» Amon says.

Disorders caused by aneuploidy are unusual in that the severity of their effects often varies widely from one individual to another.

Half or more (sometimes all) embryos in a particular IVF treatment cycle are aneuploid, and while we can't prove this, we suspect that the majority of natural conceptions are affected by aneuploidy as well.

Not exact matches

When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated for abruption.In this large, population - based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.

Many tumors are characterized by «aneuploidy,» meaning they display an abnormal number of chromosomes and chromosomal segments.

In 2005 Duesberg was invited by the National Institutes of Health — which had long since dismissed him and his research — to give a grand rounds presentation on his aneuploidy work.

Telomeres respond to aneuploidy by generating stress signals that suppress the proliferation of aneuploid cells.

I'd like to conclude with one of my favorite books, Oncogenes, Aneuploidy, and AIDS, by Harvey Bialy, about the career of scientist Peter Duesberg.

Around 75 per cent of miscarriages are thought to be caused by an embryo having the wrong number of chromosomes — a condition called aneuploidy.

The paper «Non-canonical function of SAC proteins after APC activation reduces aneuploidy in mouse oocytes» is published in the journal Nature Communications and was funded by the Australian Research Council.

These results provide evidence that aneuploidy is also generated by a-α sexual reproduction.

However, the parasexual progeny of C. albicans are characterized by high rates of aneuploidy [44].

Down Syndrome belongs to the group of conditions called «aneuploidies», defined by an abnormal loss or gain of genetic material, i.e. fragments of chromosomes or whole chromosomes.

14:20 The Importance of Pre-Test Counseling in Aneuploidy Screening by cffDNA: Patients» Experiences

Although domesticated isolates exhibit high variation in ploidy, aneuploidy and genome content, genome evolution in wild isolates is mainly driven by the accumulation of single nucleotide polymorphisms.

We also study the hereditary cancer predisposition syndrome Mosaic Variegated Aneuploidy (OMIM 257300) that is characterized by extensive aneuploidy and childhoAneuploidy (OMIM 257300) that is characterized by extensive aneuploidy and childhoaneuploidy and childhood cancer.

In research funded by the Wellcome Trust, Professor Zernicka - Goetz and colleagues developed a mouse model of aneuploidy by mixing 8 - cell stage mouse embryos in which the cells were normal with embryos in which the cells were abnormal.

The team's work highlights this by presenting a comprehensive view of genome evolution on many different levels (e.g., differences in ploidy, aneuploidy, genetic variants, hybridization, and introgressions) that is difficult to obtain at the same scale and accuracy for other eukaryotic organisms.

These results reveal that aneuploidy induced by transient centrosome amplification can accelerate tumorigenesis in p53 - deficient cells.

Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??

A low, non-genotoxic, dose (about 1 nM) of ActD has been shown to induce a reversible cytostatic effect in normal proliferating dermal fibroblasts and protect them from the aneuploidy induced by the aurora kinase inhibitor VX - 680 and the toxic effects of gemcitabine [46, 47].

By identifying phenotypes that are shared among tumors with different aneuploidies, we hope to discover pathways that can be manipulated to selectively eliminate aneuploid cells or to block aneuploidy's non-cell autonomous effects.

Noninvasive prenatal testing (NIPT) by maternal plasma DNA sequencing is now clinically available for screening fetal chromosomal aneuploidies; these tests have close to 99 % sensitivity..

Although high in promastigotes in vitro, aneuploidy dropped significantly in hamster amastigotes, in a progressive and strain - specific manner, accompanied by the emergence of new polysomies.