The plasma concentrations of
apoproteins B - 100 and E, the two ligands for the LDL receptor, declined
by more than 90 percent after cadmium treatment, but the concentration of another
apoprotein, A-I, was unaffected.
Albumin normally constitutes about 60 % of human plasma protein and plays an important role in regulating blood volume
by maintaining the oncoosmotic pressure of blood needed to avoid edema, and
by serving as the carrier for hydrophobic molecules, including lipid soluble hormones, bile salts, unconjugated bilirubin, free fatty acids (
apoprotein), calcium, ions (transferrin), and some drugs (e.g., warfarin, phenobutazone, clofibrate & phenytoin).