Sentences with phrase «by apoptotic»

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.

Bcl - 2 protein expression is topographically restricted in tissue characterized by apoptotic cell death.

Not exact matches

«Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages»

Dr. Steven R. Goodman, Editor - in - Chief of Experimental Biology and Medicine, said «This study by Huanbiao Mo and colleagues at the Texas Woman's University and UT Southwestern Medical Center demonstrates that geranylgeraniol causes dose dependent apoptotic death of human prostate carcinoma cells.

She recently co-authored a paper with Kantorow and research colleagues titled «Integrin αVβ5 - mediated removal of apoptotic cell debris by the eye lens and its inhibition by UV - light exposure,» published in the Journal of Biological Chemistry.

Moreover, the allospecific apoptotic activity of the putative DN T cells was abolished in two separate experiments using in vitro treatment with anti-Thy 1.2 antibody plus complement, which removed > 97 % of the Thy 1 + cells, as determined by flow cytometry.

Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway.

Evidence suggests that the resolution of infection and thus inflammation is prolonged due to reduced clearance of apoptotic cells and debris by macrophages.11 These age - associated alterations in innate immunity may contribute to increased systemic inflammation termed «inflamm - ageing» observed in aged tissues.10

Interestingly, p21 - null lymphomas exhibited a high level of apoptosis with tangible apoptotic bodies, often surrounded by a narrow halo indicative of phagocytosis (Fig. 4B) ⇓.

Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN - γ in a nitric oxide - dependent manner.

By providing an exogenous apoptotic gene, which is only transiently expressed in cells that already have the p16 gene active, we can precisely induce the senescent cell to commit suicide.

More recently, his research has focused on molecular mechanisms that establish the apoptotic program in response to protein misfolding in the ER, studies that have shed light on the mechanism by which cancer cells survive in a stressful environment.

For example, by engineering PA - GFP tagged to a mitochondrial matrix protein (mito - PAGFP) the Youle Lab was able to visualize and quantify the fusion dynamics of mitochondria in healthy and apoptotic cells (9).

(D) Apoptotic cells detected by the TUNEL assay (× 400).

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer.

Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly on the production of highly aneuploid cells that delaminate from the epithelium and activate a JNK - dependent transcriptional response.

Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells

The expression of micro-RNA miR - 663 was induced by mitochondrial reactive oxygen species production, an apoptotic signal and oxidative stress response, and miR - 663 induced the expression of nuclear - encoded mitochondrial respiratory chain subunits.

The extrinsic apoptotic pathway is activated by external signals through transmembrane tumour necrosis factor receptors (TNFRs) whose intracellular death domain interacts with downstream adaptors.

The number of TUNEL - positive cells in approximately 250 seminiferous tubules of each mouse was counted, and the apoptotic indices were then determined by calculating the ratio of the total number of TUNEL - positive cells / number of counted seminiferous tubules.

By examining this damage, it was found that the Bax / Bcl2 ratio, a parameter that is indicative of the apoptosis status [21], was increased in the testes of IVC - derived males, suggesting that there were a high number of apoptotic cells in that tissue, and this was confirmed by TUNEL assaBy examining this damage, it was found that the Bax / Bcl2 ratio, a parameter that is indicative of the apoptosis status [21], was increased in the testes of IVC - derived males, suggesting that there were a high number of apoptotic cells in that tissue, and this was confirmed by TUNEL assaby TUNEL assay.

Mutations in RNAse L that impair the apoptotic response to viral infection were postulated to reflect enhanced susceptibility to infection by XMRV and suggested a potential role for the virus in carcinogenesis [5], [6], [7], [8].

Next, we found that the increase of p21Cip1 / WAF1 expression, which occurs upon LA exposure in a p53 - independent manner, is involved in the apoptotic effects prompted by LA in both breast and endometrial cancer cells.

Modulation of age - induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.

Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin - proteasome systems by phosphatidylinositol 3 kinase