Sentences with phrase «by autophagy»

Neurodegeneration - associated aggregation - prone proteins are predominantly degraded by autophagy and therefore stimulating this process with chemical inducers is beneficial in a wide range of transgenic disease models.

Fasting gradually becomes «pure» fat burning, once (diabetic) stores of glycogen and liver fats and ARE GONE AND proteins scavenged by autophagy has been used up.

«This remodeling process of the cell proteome by autophagy is an important immune - suppressive survival mechanism for Ras - driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.

The researchers found that too much or too little activity by the autophagy protein BEC - 1 in neurons, muscles and the intestine is detrimental to germline cell proliferation.

Since Ras - driven cancers often rely on autophagy for growth and survival, this raised the question: Is proteome remodeling by autophagy important, and if so, by what mechanism?

The team showed that when a cell's DNA is damaged or an oncogene is activated (both of which can cause cancer), a normal cell triggers the digestion of nuclear lamina by autophagy, which promotes senescence.

Looking toward the future, the team reasons that specific manipulation of the nuclear digestion by autophagy holds promise to intervene in age - related diseases.

Previously, all known substances consumed by autophagy took place outside the nucleus in the cell's cytoplasm.

Daniel Papinski, shared first author of the study, explains: «In cells without these coordinators, we were able to promote waste removal by autophagy when Atg1 was artificially forced to meet the waste.

Morphological homeostasis by autophagy.

Working in yeast and mammalian cells, researchers showed that stress granules are cleared by autophagy, which stalled when VCP was mutated.

Of note, certain types of cancer cell, including pancreatic and lung cancer cells, are heavily reliant on growth benefits brought by autophagy activation, therefore becoming «addicted» to autophagy.

Here we show that SMN protein is degraded by autophagy.

«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks for growth in a stressed tumor micro-environment» said White, «Preclinical models have demonstrated a critical role for autophagy in multiple cancer types.»